Testosterone, Hemostasis, and Cardiovascular Diseases in Men

The publisher regrets an error in data in Table 1 and Reference 36 in the above article in Seminars in Thrombosis & Hemostasis, Volume 37, Number 1, 2011, p. 90 and p. 93, respectively. The correct table and reference are given below.

Table 1 Studies on testosterone, tissue factor–induced coagulation, and fibrinolysis

References	Study design	Study population	No. of patients	Major findings
Agledahl et al19	Case–control	Hypogonadal elderly men and controls (60–80 years of age)	37 vs. 41	Low T levels are associated with lower levels of TFPI Ag and shorter initiation phase of coagulation
Agledahl et al22	Double-blind placebo controlled (48 wk)	Hypogonadal elderly men (60–80 years of age)	26	T treatment did neither cause significant changes in thrombin generation ex vivo nor change plasma levels of TFPI Ag
Bonithon-Kopp et al32	Cross-sectional	Healthy middle-aged men	251	T correlated negatively to FVII Ac and α 2-antiplasmin. No association between T, fibrinogen, and AT levels
De Pergola et al34	Case–control cross-sectional	Healthy men with BMI > 25 and nonobese controls	40 vs. 24	Men with lower free T in serum have higher fibrinogen and FVII Ag levels
Phillips et al36	Observational cross-sectional	Men with CVD without previously AMI	34	T correlated negatively with fibrinogen and PAI-1 levels
Yang et al37	Cross-sectional	Healthy men with BMI < 26	48	T correlated negatively with fibrinogen and PAI-1 levels
Glueck et al38	Observational cross-sectional	Hyperlipidemic men	55	T independent inverse predictor of fibrinogen and tPA Ag
Pugh et al39	Prospective Case–control	Men with AMI and healthy controls	22 vs. 8	Total and free T fell acutely following AMI with elevation of PAI-1 and tPA Ac
Smith et al45	Double-blind placebo-controlled (8 wk)	Men with stable angina	46	T treatment did not change fibrinogen, tPA, or PAI-1 activity
Anderson et al44	Double-blind placebo-controlled (52 wk)	Healthy young men	32	T treatment reduced fibrinogen levels. AT and F1.2 rose initially during treatment, and levels of PC, PS, and PAI-1 fell but returned to pretreatment levels during continued treatment

Abbreviations: Ag, antigen; AMI, acute myocardial infarction; AT, antithrombin; BMI, body mass index; CVD, coronary vascular disease; F, factor; F1.2, fragment 1 and 2; FVII Ac, factor VII activity; PAI-I, plasminogen activator inhibitor; PC, protein C; PS, protein S; T, testosterone; TFPI Ag, tissue factor pathway inhibitor antigen; tPA ac, tissue plasminogen activator activity.

Reference

36 Phillips GB, Pinkernell BH, Jing TY. The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb 1994;14(5):701–706