Effects of Marathon Running on Cardiac Markers and Endothelin-1 in EIH Athletes

Y. J. Kim; Y. O. Shin; Y. H. Lee; H. M. Jee; K. A. Shin; C. W. Goh; C. H. Kim; Y. K. Min; H. M. Yang; J. B. Lee

doi:10.1055/s-0032-1331257

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2013; 34(09): 777-782
DOI: 10.1055/s-0032-1331257

Physiology & Biochemistry

Effects of Marathon Running on Cardiac Markers and Endothelin-1 in EIH Athletes

Y. J. Kim

¹Department of Rehabilitation Medicine, Inje University Paik Hospital, Seoul, Republic of Korea

,

Y. O. Shin

²Department of Health Care, Graduate school, Soonchunhyang University, Asan, Republic of Korea

,

Y. H. Lee

³Department of Sports Physiology, Korea National Sport University, Seoul, Republic of Korea

,

H. M. Jee

⁴Exercise and Health Management, Namseoul University, Cheonan-si,Republic of Korea

,

K. A. Shin

⁵Laboratory Medicine, Bun-dang Je-saeng hospital, Sungnam-si, Republic of Korea

,

C. W. Goh

⁶Cardiology, Sanggye-Paik Hospital, Inje University, Seoul, Republic of Korea

,

C. H. Kim

⁷Department of Physiology and Biophysics, Eulji University School of Medicine, Daejeon-si, Republic of Korea

,

Y. K. Min

⁸Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea

,

H. M. Yang

⁸Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea

,

J. B. Lee

⁸Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea

› Author Affiliations

Abstract

The aim of the present study was to determine the changes in cardiac makers and endothelin-1 (ET-1) in marathoners with exercise induced hypertension compared to normotensive controls before and after running a marathon. Among a total of 70 volunteers, 10 marathoners with systolic blood pressure (SBP) greater than 210 mmHg during a treadmill exercise stress test were selected as an exercise-induced hypertension group (EIH) and 10 marathoners with normal SBP were selected as a control group (CON). Blood was collected from all volunteers 2 h before and immediately after a marathon: creatinine kinase (CK), CK-MB, cardiac tropoin-I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), and endothelin-1(ET-1). Cardiac markers, CK, CK-MB, and CK-MB/CK ratio significantly increased in both EIH and CON; significance was not observed between the groups. Significant increases were not observed in high sensitive-C reactive protein (hs-CRP) after the race nor between the groups. Significant increases in cTnI and NT-proBNP were observed after the race in both groups. In addition, EIH showed greater increase than CON after the race. In conclusion, increased vascular tone in EIH during a marathon increased blood pressure and myocardial burden which in turn increased myocardial cell membrane permeability to further increase myocardial tension to the point of cTnI release.

Key words

hypertension - creatine kinase - cTnI - NT-proBNP

Full Text

References

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