Download PDF
Pneumologie 2013; 67(S 02): S100-S101
DOI: 10.1055/s-0033-1344748
Extended Abstract
© Georg Thieme Verlag KG Stuttgart · New York

Wirkung des sGC-Stimulators Riociguat auf das pulmonalvaskuläre und rechtsventrikuläre Remodeling bei schwerer pulmonal-arterieller Hypertonie

Effects of sGC-stimulator Riociguat on Pulmonary Vascular and Right Ventricular Remodeling in Severe Pulmonary Arterial Hypertension

Authors

  • B. Kojonazarov

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • M. Lang

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • X. Tian

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • A. Kalymbetov

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • N. Weißmann

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • F. Grimminger

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • A. Kretschmer

    2   Bayer Healthcare AG, Wuppertal

  • J.-P. Stasch

    2   Bayer Healthcare AG, Wuppertal

  • H.-A. Ghofrani

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • W. Seeger

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

  • R. T. Schermuly

    1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen

Subject Editor:
Further Information

Publication History

Publication Date:
09 December 2013 (online)

Also available at
   Permissions and Reprints
Preview

Hintergrund

Der NO-sGC-cGMP-Signaltransduktionsweg (NO = Stickstoffmonoxid; sGC = lösliche Guanylatcyclase; cGMP = zyklisches Guanosinmonophosphat) ist bei vielen Herzkreislauferkrankungen einschließlich der pulmonal-arteriellen Hypertonie (PAH) gestört. Bei Riociguat (BAY 63 – 2521) handelt es sich um einen sGC-Stimulator, der den cGMP-Spiegel sowohl in Synergie mit NO als auch unabhängig davon erhöht. Ziel dieser Studie war es, die Rolle der NO-sGC-cGMP-Signalgebung in einem Modell mit schwerer PAH zu untersuchen und die Wirkung der sGC-Stimulation durch Riociguat sowie der PDE5-Inhibition durch Sildenafil auf die pulmonale Hämodynamik und das vaskuläre Remodeling bei schwerer experimenteller PAH zu bewerten.