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Neuropediatrics 2013; 44(05): 252-256
DOI: 10.1055/s-0033-1347934
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Characteristic Features of Migraine in Schoolchildren and Adolescents and Its Relationship with Autonomic Nervous System Disorders

Emel Torun
1   Department of Pediatrics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
,
Esra Gursoy
2   Department of Neurology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
,
Serhat Guler
3   Department of Pediatric Neurology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
,
Mehmet Kolukisa
2   Department of Neurology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
,
Burak Tatli
3   Department of Pediatric Neurology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

17 November 2012

02 April 2013

Publication Date:
14 June 2013 (online)

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Abstract

Objective The studies about autonomic nervous system (ANS) disorders in adult migraineurs show conflicting results with limited data on ANS function in childhood and adolescence. This study aimed to investigate ANS function in childhood migraine.

Patients and Methods The migraine and control groups consisted of 35 migraineurs and 30 healthy children, respectively. In both groups, heart rate interval variation (RRIV) and sympathetic skin response (SSR) were used as noninvasive ANS function tests.

Results No significant differences in age and gender distribution were found between the study and control groups. A family history of migraine was seen in 65% patients in the study group and 20% in the control group. The duration, quality, frequency, and location of pain were variable; only 14.1% of the patients had sensory and visual aural symptoms. There was neither a significant difference in RRIV and SSR between migraine and control groups (p > 0.05) nor in heart rate responses to deep breathing (p = 0.83). The mean amplitude of SSR in children with migraine was smaller than that in the control group, but it did not reach a level of statistical significance.

Conclusions In children with migraine, our results demonstrate no abnormal ANS function related to either the sympathetic or the parasympathetic nervous system.

Keywords

autonomic nervous system - migraine - schoolchildren - adolescents
 

  • References

  • 1 Olesen J. International Headache Society classification and diagnostic criteria in children: a proposal for revision. Dev Med Child Neurol 1997; 39 (2) 138
    PubMedGoogle Scholar
  • 2 Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004; 24 (Suppl. 01) 9-160
    CrossrefPubMedGoogle Scholar
  • 3 Sillanpää M. Changes in the prevalence of migraine and other headaches during the first seven school years. Headache 1983; 23 (1) 15-19
    PubMedGoogle Scholar
  • 4 Dalsgaard-Nielsen T. Some aspects of the epidemiology of migraine in Denmark. Headache 1970; 10 (1) 14-23
    CrossrefPubMedGoogle Scholar
  • 5 Deubner DC. An epidemiologic study of migraine and headache in 10-20.  year olds. Headache 1977; 17 (4) 173-180
    CrossrefPubMedGoogle Scholar
  • 6 Gelfand AA. Migraine and childhood periodic syndromes in children and adolescents. Curr Opin Neurol 2013; 26 (3) 262-268
    CrossrefPubMedGoogle Scholar
  • 7 Ducros A, Tournier-Lasserve E, Bousser MG. The genetics of migraine. Lancet Neurol 2002; 1 (5) 285-293
    CrossrefPubMedGoogle Scholar
  • 8 Welch KM. Drug therapy of migraine. N Engl J Med 1993; 329 (20) 1476-1483
    CrossrefPubMedGoogle Scholar
  • 9 Welch KM, Barkley GL, Tepley N, Ramadan NM. Central neurogenic mechanisms of migraine. Neurology 1993; 43 (6)) (Suppl. 03) S21-S25
    CrossrefPubMedGoogle Scholar
  • 10 Weiller C, May A, Limmroth V , et al. Brain stem activation in spontaneous human migraine attacks. Nat Med 1995; 1 (7) 658-660
    CrossrefPubMedGoogle Scholar
  • 11 Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002; 8 (2) 136-142
    CrossrefPubMedGoogle Scholar
  • 12 Kaube H, Katsarava Z, Przywara S, Drepper J, Ellrich J, Diener HC. Acute migraine headache: possible sensitization of neurons in the spinal trigeminal nucleus?. Neurology 2002; 58 (8) 1234-1238
    CrossrefPubMedGoogle Scholar
  • 13 Tfelt-Hansen PC. History of migraine with aura and cortical spreading depression from 1941 and onwards. Cephalalgia 2010; 30 (7) 780-792
    PubMedGoogle Scholar
  • 14 Gursoy-Ozdemir Y, Qiu J, Matsuoka N , et al. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 2004; 113 (10) 1447-1455
    CrossrefPubMedGoogle Scholar
  • 15 Winner P, Ricalde O, Le Force B, Saper J, Margul B. A doubleblind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine. Arch Neurol 1996; 53 (2) 180-184
    CrossrefPubMedGoogle Scholar
  • 16 Lassen LH, Haderslev PA, Jacobsen VB, Iversen HK, Sperling B, Olesen J. CGRP may play a causative role in migraine. Cephalalgia 2002; 22 (1) 54-61
    CrossrefPubMedGoogle Scholar
  • 17 Pogacnik T, Sega S, Pecnik B, Kiauta T. Autonomic function testing in patients with migraine. Headache 1993; 33 (10) 545-550
    CrossrefPubMedGoogle Scholar
  • 18 Rubin LS, Graham D, Pasker R, Calhoun W. Autonomic nervous system dysfunction in common migraine. Headache 1985; 25 (1) 40-48
    CrossrefPubMedGoogle Scholar
  • 19 Yakinci C, Mungen B, Er H, Durmaz Y, Karabiber H. Autonomic nervous system function in childhood migraine. Pediatr Int 1999; 41 (5) 529-533
    CrossrefPubMedGoogle Scholar
  • 20 Balottin U, Arisi D, Frigo GM, Lanzi G. Iris adrenergic sensitivity and migraine in pediatric patients. Headache 1983; 23 (1) 32-33
    PubMedGoogle Scholar
  • 21 Claus D, Schondorf R. Sympathetic skin response. In: G. Deuschl, A. Eishen, eds. Recommendation for the Practice of Clinical Neurophysiology. Vancouver, BC, Canada: Elsevier; 1999: 276-277
    Google Scholar
  • 22 Lance JW. Current concepts of migraine pathogenesis. Neurology 1993; 43 (6) (Suppl. 03) S11-S15
    CrossrefPubMedGoogle Scholar
  • 23 Hachinski VC, Porchawka J, Steele JC. Visual symptoms in the migraine syndrome. Neurology 1973; 23 (6) 570-579
    CrossrefPubMedGoogle Scholar
  • 24 Bannister R, Mathias CJ. Testing autonomic reflexes. In: Bannister R, , ed. Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System, 2nd ed. Oxford: Oxford University Press; 1988: 289-307
    Google Scholar
  • 25 Chelimsky TC, Chelimsky GG. Autonomic abnormalities in cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2007; 44 (3) 326-330
    CrossrefPubMedGoogle Scholar
  • 26 Hejazi RA, Lavenbarg TH, Pasnoor M , et al. Autonomic nerve function in adult patients with cyclic vomiting syndrome. Neurogastroenterol Motil 2011; 23 (5) 439-443
    CrossrefPubMedGoogle Scholar
  • 27 Shechter A, Stewart WF, Silberstein SD, Lipton RB. Migraine and autonomic nervous system function: a population-based, case-control study. Neurology 2002; 58 (3) 422-427
    CrossrefPubMedGoogle Scholar
  • 28 Havanka-Kanniainen H. Cardiovascular reflexes responsesduring migraine attack. Headache 1986; 26 (9) 422-446
    PubMedGoogle Scholar
  • 29 Cortelli P, de Carolis P, Sturani A , et al. Cardiovascular and biochemical assessment in migraine patients submitted to tilt test. Funct Neurol 1986; 1 (3) 285-290
    PubMedGoogle Scholar
  • 30 Anthony M. Biochemical indices of sympathetic activity in migraine. Cephalalgia 1981; 1 (2) 83-89
    CrossrefPubMedGoogle Scholar
  • 31 Havanka-Kanniainen H, Tolonen U, Myllylä VV. Autonomic dysfunction in adult migraineurs. Headache 1986; 26 (8) 425-430
    CrossrefPubMedGoogle Scholar
  • 32 Havanka-Kanniainen H, Juujarvi K, Tolonen U, Myllyla VV. Cardiovascular reflex and plasma noradrenaline levels in migraine patients before and during dimodipine medication. Headache 1987; 27 (1) 34-44
    CrossrefPubMedGoogle Scholar
  • 33 Havanka-Kanniainen H, Tolonen U, Myllylä VV. Autonomic dysfunction in migraine: a survey of 188 patients. Headache 1988; 28 (7) 465-470
    CrossrefPubMedGoogle Scholar
  • 34 Appel S, Kuritzky A, Zahavi I, Zigelman M, Akselrod S. Evidence for instability of the autonomic nervous system in patients with migraine headache. Headache 1992; 32 (1) 10-17
    CrossrefPubMedGoogle Scholar