Abstract
Objective:
Hypertensive patients have higher prevalence of insulin resistance and are at increased
risk of developing type 2 diabetes mellitus (DM). There is scarcity of data on the
relationship between antihypertensive therapies and glycaemic control in Indian population.
Thus, the present study was designed to investigate such association among Indian
population in a University teaching hospital.
Methods:
The study was carried out on 177 hypertensive patients (with new onset of diabetes
or without diabetes) visiting the OPD of medicine department at Majeedia hospital,
New Delhi. The drug history of hypertensive patients and blood glucose levels following
1–5 yrs of antihypertensive therapy were recorded.
Results:
The gender distribution of hypertensive patients reveals a higher percentage of incidences
in males (53.7%) as compared to females (46.3%). Hypertensive patient without DM on
beta blockers and on thiazide shows higher incidence of impaired glucose tolerance
(IGT) (17.5%, 18.5%) and DM (10%, 11%) as compared to patient receiving other antihypertensive
therapy. While in patients of new onset diabetes the incidence was higher with β-blockers
(56.2%) than with thiazides (31.3%) followed by calcium channel blockers (CCBs) (12.5%).
There was proportionate increase in incidence with the duration of therapy (3–5 years).
None of the patients who were on ACE inhibitors or on angiotensin receptor blockers
(ARBs) reported any incidence of IGT or DM.
Conclusion:
To conclude, β-blockers and thiazides increases the risk of type 2 diabetes mellitus
with long term antihypertensive therapy requiring regular monitoring. CCBs have lowered
risks while ACE inhibitors and ARBs are relatively free of such metabolic adverse
effects.
Key words
hypertension - diabetes mellitus - impaired glucose tolerance - beta blockers - ACEIs
- thiazide - ARBs - CCBs
