Abstract
Opsoclonus myoclonus syndrome (dancing eye syndrome) is a rare paraneoplastic syndrome
characterized by opsoclonus, myoclonus, and ataxia, usually accompanied by behavioral
abnormalities. In adults, opsoclonus myoclonus syndrome has been reported in association
with different types of cancer; whereas in children, the syndrome may be associated
with neuroblastic tumors. Although a direct proof is lacking, the syndrome is assumed
to be of autoimmune origin. The treatment is corticosteroid based with the addition
of other immunosuppressive or immunomodulating drugs if intensification seems necessary.
Because of the rarity of the disease, international collaborations as well on research
as on therapeutic strategies are urgently needed. A European consortium just started
a trial for this rare condition.
Keywords
opsoclonus myoclonus syndrome - dancing eye syndrome - neuroblastoma
