Abstract
Over the past decade, there has been a dramatic evolution of genetic methodologies
that can be used to identify genes contributing to disease. Initially, the focus was
primarily on classical linkage analysis; more recently, genomewide association studies,
and high-throughput whole genome and whole exome sequencing have provided efficient
approaches to detect common and rare variation contributing to disease risk. Application
of these methodologies to dementias has led to the nomination of dozens of causative
and susceptibility genes, solidifying the recognition that genetic factors are important
contributors to the disease processes. In this review, the authors focus on current
knowledge of the genetics of Alzheimer's disease and frontotemporal lobar degeneration.
A working understanding of the genes relevant to common dementias will become increasingly
critical, as options for genetic testing and eventually gene-specific therapeutics
are developed.
Keywords
genetic risk factors - dementia - Alzheimer's disease - frontotemporal lobar degeneration
