Dementia with Lewy Bodies

Jennifer Rose V. Molano

doi:10.1055/s-0033-1359315

Seminars in Neurology, Inhaltsverzeichnis

Semin Neurol 2013; 33(04): 330-335
DOI: 10.1055/s-0033-1359315

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Dementia with Lewy Bodies

Jennifer Rose V. Molano

¹Department of Neurology and Rehabilitation Medicine, The University of Cincinnati College of Medicine, Cincinnati, Ohio

› Institutsangaben

Abstract

Dementia with Lewy bodies (DLB) is a synucleinopathy that is clinically distinct from Alzheimer's disease, associated with cognitive decline, fluctuations in alertness and cognition, visual hallucinations, and parkinsonism. Other clinical symptoms that can occur with DLB include dysautonomia and sleep disorders such as rapid-eye-movement sleep behavior disorder (RBD). The pathological criteria of DLB are associated with the location of Lewy body pathology and the extent of Alzheimer's pathology seen. Treatment is symptomatic. The genetic basis of DLB is being explored, and future studies will investigate ways to identify those most at risk for DLB prior to the onset of cognitive symptoms.

Keywords

Lewy bodies - synucleinopathy - REM sleep behavior disorder - dysautonomia - parkinsonism

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Referenzen

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