Pränatale Diagnostik und Therapie bei kongenitaler Zwerchfellhernie

J. Ritgen; T. Kohl; C. Enzensberger; R. Axt-Fliedner; T. Schaible; R. Stressig

doi:10.1055/s-0034-1367041

Zeitschrift für Geburtshilfe und Neonatologie, Inhaltsverzeichnis

Z Geburtshilfe Neonatol 2014; 218(01): 6-17
DOI: 10.1055/s-0034-1367041

Übersicht

Pränatale Diagnostik und Therapie bei kongenitaler Zwerchfellhernie

Prenatal Diagnosis of and Therapy for Congenital Diaphragmatic Hernia

Authors

J. Ritgen

¹Praxis für Pränatalmedizin und Genetik Köln/Düsseldorf
T. Kohl

²Deutsches Zentrum für Fetalchirurgie & minimal-invasive Therapie (DZFT), Justus-Liebig Universität Gießen und Universitätsklinikum Gießen & Marburg
C. Enzensberger

³Abteilung für Pränatalmedizin und gynäkologische Sonografie, Klinik für Frauenheilkunde und Geburtshilfe, Justus-Liebig Universität Gießen und Universitätsklinikum Gießen & Marburg
R. Axt-Fliedner

³Abteilung für Pränatalmedizin und gynäkologische Sonografie, Klinik für Frauenheilkunde und Geburtshilfe, Justus-Liebig Universität Gießen und Universitätsklinikum Gießen & Marburg
T. Schaible

⁴Universitäts-Kinderklinik Mannheim
R. Stressig

¹Praxis für Pränatalmedizin und Genetik Köln/Düsseldorf

Abstract

Zusammenfassung

Die Diagnose kongenitale Zwerchfellhernien umfasst eine inhomogene Gruppe unterschiedlicher Schweregrade dieser Erkrankung. Eine möglichst genaue vorgeburtliche Einschätzung der Prognose ist für die Beratung der betroffenen Eltern und für weitere Therapieentscheidungen von zentraler Bedeutung. Die fetale Therapie der kongenitalen Zwerchfellhernie (FETO) kann erwiesenermaßen die Prognose verbessern. Vor allem bei einer zu erwartenden ECMO-Pflichtigkeit ist die frühzeitige Anbindung an ein entsprechendes Zentrum wichtig.

Abstract

Congenital diaphragmatic hernia is a malformation presenting with varying degrees of severity. An accurate prediction of outcome is crucial for parental counselling and therapeutic planning. In selected cases, foetal endoscopic tracheal occlusion (FETO) can improve foetal outcome. Timely referral to a highly specialised centre is important when the requirement for extracorporeal membrane oxygenation (ECMO) is expected.

Schlüsselwörter

kongenitale Zwerchfellhernie - pränatale Diagnose - Prognosekriterien - fetale Echokardiografie - Trachealokklusion

Key words

congenital diaphragmatic hernia - prenatal diagnosis - antenatal predictors of survival - echocardiography - foetal tracheal occlusion

Volltext

Referenzen

Literatur
1 Bedoyan JK, Blackwell SC, Treadwell MC et al. Congenital diaphragmatic hernia: associated anomalies and antenatal diagnosis. Outcome-related variables at two Detroit hospitals. Ped Surgery Int 2004; 20: 170-176
2 Skari H, Bjornland K, Haugen G et al. Congenital diaphragmatic hernia: a meta-analysis of mortality factors. Journal of Pediatric Surgery 2000; 35: 1187-1197
3 Harrison MR, Bjordal RI, Langmark F et al. Congenital diaphragmatic hernia: the hidden mortality. Journal of Pediatric Surgery 1978; 13: 227-230
4 Mayer S, Klaritsch P, Petersen S et al. The correlation between lung volume and liver herniation measurements by fetal MRI in isolated congenital diaphragmatic hernia: a systematic review and meta-analysis of observational studies. Prenat Diagn 2011; 31: 1086-1096
5 Babiuk RP, Zhang W, Clugston R et al. Embryological origins and development of the rat diaphragm. J Comp Neurol 2003; 455: 477-487
6 Brady PD, Srisupundit K, Devriendt K et al. Recent developments in the genetic factors underlying congenital diaphragmatic hernia. Fetal Diagn Ther 2011; 29: 25-39
7 Wigglesworth JS, Desai R, Guerrini P. Fetal lung hypoplasia: biochemical and structural variations and their possible significance. Arch Dis Child 1981; 56: 606-615
8 Moessinger AC. Lung hypoplasia and polyhydramnios found in association with congenital diaphragmatic hernia. Journal of Pediatric Surgery 1990; 25: 1307-1308
9 Adzick NS, Outwater KM, Harrison MR et al. Correction of congenital diaphragmatic hernia in utero. IV. An early gestational fetal lamb model for pulmonary vascular morphometric analysis. Journal of Pediatric Surgery 1985; 20: 673-680
10 Sokol J, Bohn D, Lacro RV et al. Fetal pulmonary artery diameters and their association with lung hypoplasia and postnatal outcome in congenital diaphragmatic hernia. Am J Obstet Gynecol 2002; 186: 1085-1090
11 Rottier R, Tibboel D. Fetal lung and diaphragm development in congenital diaphragmatic hernia. Seminars in Perinatology 2005; 29: 86-93
12 Reiss I, Schaible T, van den Hout L et al. Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium consensus. Neonatology 2010; 354-364
13 van den Hout L, Schaible T, Cohen-Overbeek TE et al. Actual outcome in infants with congenital diaphragmatic hernia: the role of a standardized postnatal treatment protocol. Fetal Diagn Ther 2011; 29: 55-63
14 Adzick NS, Harrison MR, Glick PL et al. Diaphragmatic hernia in the fetus: prenatal diagnosis and outcome in 94 cases. Journal of Pediatric Surgery 1985; 20: 357-361
15 Adzick NS, Vacanti JP, Lillehei CW et al. Fetal diaphragmatic hernia: ultrasound diagnosis and clinical outcome in 38 cases. Journal of Pediatric Surgery 1989; 24: 654-657 discussion 657–658
16 Schaible T, Büsing K-A, Felix JF et al. Prediction of chronic lung disease, survival and need for ECMO therapy in infants with congenital diaphragmatic hernia: additional value of fetal MRI measurements?. Eur J Radiol 2012; 81: 1076-1082
17 Jani JC, Benachi A, Nicolaides KH et al. Prenatal prediction of neonatal morbidity in survivors with congenital diaphragmatic hernia: a multicenter study. Ultrasound Obstet Gynecol 2009; 33: 64-69
18 Cunniff C, Jones KL, Jones MC. Patterns of malformation in children with congenital diaphragmatic defects. J Pediatr 1990; 116: 258-261
19 Enns GM, Cox VA, Goldstein RB et al. Congenital diaphragmatic defects and associated syndromes, malformations, and chromosome anomalies: a retrospective study of 60 patients and literature review. Am J Med Genet 1998; 79: 215-225
20 Dommergues M, Louis-Sylvestre C, Mandelbrot L. Congenital diaphragmatic hernia: can prenatal ultrasonography predict outcome?. Am J Obstet Gynecol 1996; 174: 1377-1381
21 Deprest JA, Nicolaides K, Gratacos E. Fetal surgery for congenital diaphragmatic hernia is back from never gone. Fetal Diagn Ther 2011; 29: 6-17
22 Ruano R, Yoshisaki CT, da Silva MM et al. A randomized controlled trial of fetal endoscopic tracheal occlusion versus postnatal management of severe isolated congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2012; 39: 20-27
23 Howe DT, Kilby MD, Sirry H et al. Structural chromosome anomalies in congenital diaphragmatic hernia. Prenat Diagn 1996; 16: 1003-1009
24 Thorpe-Beeston JG, Gosden CM, Nicolaides KH. Prenatal diagnosis of congenital diaphragmatic hernia: associated malformations and chromosomal defects. Fetal Ther 1989; 4: 21-28
25 Claus F, Sandaite I, DeKoninck P et al. Prenatal anatomical imaging in fetuses with congenital diaphragmatic hernia. Fetal Diagn Ther 2011; 29: 88-100
26 Bootstaylor BS, Filly RA, Harrison MR et al. Prenatal sonographic predictors of liver herniation in congenital diaphragmatic hernia. J Ultrasound Med 1995; 14: 515-520
27 Hatch EI, Kendall J, Blumhagen J. Stomach position as an in utero predictor of neonatal outcome in left-sided diaphragmatic hernia. Journal of Pediatric Surgery 1992; 27: 778-779
28 Ruano R, Takashi E, da Silva MM et al. Prediction and probability of neonatal outcome in isolated congenital diaphragmatic hernia using multiple ultrasound parameters. Ultrasound Obstet Gynecol 2012; 39: 42-49
29 Kiserud T, Eik-Nes SH, Blaas HG et al. Ultrasonographic velocimetry of the fetal ductus venosus. Lancet 1991; 338: 1412-1414
30 Kiserud T, Eik-Nes SH, Blaas HG et al. Foramen ovale: an ultrasonographic study of its relation to the inferior vena cava, ductus venosus and hepatic veins. Ultrasound Obstet Gynecol 1992; 2: 389-396
31 Beaudoin S, Bargy F, Mahieu D et al. Anatomic study of the umbilical vein and ductus venosus in human fetuses: ultrasound application in prenatal examination of left congenital diaphragmatic hernia. Surg Radiol Anat 1998; 20: 99-103
32 Albanese CT, Lopoo J, Goldstein RB et al. Fetal liver position and perinatal outcome for congenital diaphragmatic hernia. Prenat Diagn 1998; 18: 1138-1142
33 Mullassery D, Ba’ath ME, Jesudason EC et al. Value of liver herniation in prediction of outcome in fetal congenital diaphragmatic hernia: a systematic review and meta-analysis. Ultrasound Obstet Gynecol 2010; 35: 609-614
34 Schaible T, Kohl T, Reinshagen K et al. Right- versus left-sided congenital diaphragmatic hernia-postnatal outcome at a specialized tertiary care center. Pediatr Crit Care Med 2011; 13: 66-71
35 Jani JC, Nicolaides KH, Gratacos E et al. FETO Task Group . Fetal lung-to-head ratio in the prediction of survival in severe left-sided diaphragmatic hernia treated by fetal endoscopic tracheal occlusion (FETO). Am J Obstet Gynecol 2006; 195: 1646-1650
36 Jani J, Keller RL, Benachi A et al. Prenatal prediction of survival in isolated left-sided diaphragmatic hernia. Ultrasound Obstet Gynecol 2006; 27: 18-22
37 Thébaud B, Azancot A, de Lagausie P et al. Congenital diaphragmatic hernia: antenatal prognostic factors. Does cardiac ventricular disproportion in utero predict outcome and pulmonary hypoplasia?. Intensive Care Med 1997; 23: 10062-10069
38 Vogel M, McElhinney DB, Marcus E et al. Significance and outcome of left heart hypoplasia in fetal congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2010; 35: 310-317
39 Metkus AP, Filly RA, Stringer MD et al. Sonographic predictors of survival in fetal diaphragmatic hernia. Journal of Pediatric Surgery 1996; 31: 148-151 discussion 151–152
40 Lipshutz GS, Albanese CT, Feldstein VA et al. Prospective analysis of lung-to-head ratio predicts survival for patients with prenatally diagnosed congenital diaphragmatic hernia. Journal of Pediatric Surgery 1997; 32: 1634-1636
41 Flake AW, Crombleholme TM, Johnson MP et al. Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases. Am J Obstet Gynecol 2000; 183: 1059-1066
42 Laudy JAM, Van Gucht M, Van Dooren MF et al. Congenital diaphragmatic hernia: an evaluation of the prognostic value of the lung-to-head ratio and other prenatal parameters. Prenat Diagn 2003; 23: 634-639
43 Arkovitz MS, Russo M, Devine P et al. Fetal lung-head ratio is not related to outcome for antenatal diagnosed congenital diaphragmatic hernia. Journal of Pediatric Surgery 2007; 42: 107-110 discussion 110–111
44 Harrison MR, Mychaliska GB, Albanese CT et al. Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis (liver herniation and low lung-to-head ratio) can be saved by fetoscopic temporary tracheal occlusion. Journal of Pediatric Surgery 1998; 33: 1017-1022 –discussion1022–1023
45 Sbragia L, Paek BW, Filly RA et al. Congenital diaphragmatic hernia without herniation of the liver: does the lung-to-head ratio predict survival?. J Ultrasound Med 2000; 19: 845-848
46 Heling KS, Wauer RR, Hammer H et al. Reliability of the lung-to-head ratio in predicting outcome and neonatal ventilation parameters in fetuses with congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2005; 25: 112-118
47 Jani J, Peralta CFA, Benachi A et al. Assessment of lung area in fetuses with congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2007; 30: 72-76
48 Jani JC, Peralta CFA, Nicolaides KH. Lung-to-head ratio: a need to unify the technique. Ultrasound Obstet Gynecol 2012; 39: 2-6
49 Peralta CFA, Cavoretto P, Csapo B et al. Assessment of lung area in normal fetuses at 12–32 weeks. Ultrasound Obstet Gynecol 2005; 26: 718-724
50 Jani J, Nicolaides KH, Keller RL et al. Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia. Ultrasound Obstet Gynecol 2007; 30: 67-71
51 Jani J, Cannie M, Sonigo P et al. Value of prenatal magnetic resonance imaging in the prediction of postnatal outcome in fetuses with diaphragmatic hernia. Ultrasound Obstet Gynecol 2008; 32: 793-799
52 Jani JC, Peralta CFA, Ruano R et al. Comparison of fetal lung area to head circumference ratio with lung volume in the prediction of postnatal outcome in diaphragmatic hernia. Ultrasound Obstet Gynecol 2007; 30: 850-854
53 Jani J, Nicolaides KH, Benachi A et al. Timing of lung size assessment in the prediction of survival in fetuses with diaphragmatic hernia. Ultrasound Obstet Gynecol 2008; 31: 37-40
54 Doné E, Gucciardo L, Van Mieghem T et al. Prenatal diagnosis, prediction of outcome and in utero therapy of isolated congenital diaphragmatic hernia. Prenat Diagn 2008; 28: 581-591
55 Moreno-Alvarez O, Cruz-Martinez R, Hernandez-Andrade E et al. Lung tissue perfusion in congenital diaphragmatic hernia and association with the lung-to-head ratio and intrapulmonary artery pulsed Doppler. Ultrasound Obstet Gynecol 2010; 35: 578-582
56 Cruz-Martinez R, Moreno-Alvarez O, Hernandez-Andrade E et al. Changes in lung tissue perfusion in the prediction of survival in fetuses with congenital diaphragmatic hernia treated with fetal endoscopic tracheal occlusion. Fetal. Diagn Ther 2011; 29: 101-107
57 Kalache KD, Espinoza J, Chaiworapongsa T et al. Three-dimensional ultrasound fetal lung volume measurement: a systematic study comparing the multiplanar method with the rotational (VOCAL) technique. Ultrasound Obstet Gynecol 2003; 21: 111-118
58 Laudy JA, Janssen MM, Struyk PC et al. Three-dimensional ultrasonography of normal fetal lung volume: a preliminary study. Ultrasound Obstet Gynecol 1998; 11: 13-16
59 Ruano R, Martinovic J, Dommergues M et al. Accuracy of fetal lung volume assessed by three-dimensional sonography. Ultrasound Obstet Gynecol 2005; 26: 725-730
60 Peralta CFA, Cavoretto P, Csapo B et al. Lung and heart volumes by three-dimensional ultrasound in normal fetuses at 12–32 weeks’ gestation. Ultrasound Obstet Gynecol 2006; 27: 128-133
61 Guibaud L, Filiatrault D, Garel L et al. Fetal congenital diaphragmatic hernia: accuracy of sonography in the diagnosis and prediction of the outcome after birth. AJR Am J Roentgenol 1996; 166: 1195-1202
62 Awadh AMA, Prefumo F, Bland JM et al. Assessment of the intraobserver variability in the measurement of fetal cardiothoracic ratio using ellipse and diameter methods. Ultrasound Obstet Gynecol 2006; 28: 53-56
63 Paek BW, Coakley FV, Lu Y et al. Congenital diaphragmatic hernia: prenatal evaluation with MR lung volumetry – preliminary experience. Radiology 2001; 220: 63-67
64 Cannie M, Jani J, De Keyzer F et al. T2 quantifications of fetal lungs at MRI-normal ranges. Prenat Diagn 2011; 31: 705-711
65 Büsing KA, Kilian AK, Schaible T et al. Reliability and validity of MR image lung volume measurement in fetuses with congenital diaphragmatic hernia and in vitro lung models. Radiology 2008; 246: 553-561
66 Sandaite I, Claus F, De Keyzer F et al. Examining the relationship between the lung-to-head ratio measured on ultrasound and lung volumetry by magnetic resonance in fetuses with isolated congenital diaphragmatic hernia. Fetal Diagn Ther 2011; 29: 80-87
67 Tanigaki S, Miyakoshi K, Tanaka M et al. Pulmonary hypoplasia: prediction with use of ratio of MR imaging-measured fetal lung volume to US-estimated fetal body weight. Radiology 2004; 232: 767-772
68 Cannie M, Jani J, Meersschaert J et al. Prenatal prediction of survival in isolated diaphragmatic hernia using observed to expected total fetal lung volume determined by magnetic resonance imaging based on either gestational age or fetal body volume. Ultrasound Obstet Gynecol 2008; 32: 633-639
69 Kilian AK, Schaible T, Hofmann V et al. Congenital diaphragmatic hernia: predictive value of MRI relative lung-to-head ratio compared with MRI fetal lung volume and sonographic lung-to-head ratio. AJR Am J Roentgenol 2009; 192: 153-158
70 Rypens F, Metens T, Rocourt N et al. Fetal lung volume: estimation at MR imaging – initial results. Radiology 2001; 219: 236-241
71 Jani J, Breysem L, Maes F et al. Accuracy of magnetic resonance imaging for measuring fetal sheep lungs and other organs. Ultrasound Obstet Gynecol 2005; 25: 270-276
72 Keller TM, Rake A, Michel SCA et al. MR assessment of fetal lung development using lung volumes and signal intensities. Eur Radiol 2004; 14: 984-989
73 Kasprian G, Balassy C, Brugger PC et al. MRI of normal and pathological fetal lung development. Eur J Radiol 2006; 57: 261-270
74 Büsing KA, Kilian AK, Schaible T et al. MR relative fetal lung volume in congenital diaphragmatic hernia: survival and need for extracorporeal membrane oxygenation. Radiology 2008; 248: 240-246
75 Büsing KA, Kilian AK, Schaible T et al. MR lung volume in fetal congenital diaphragmatic hernia: logistic regression analysis – mortality and extracorporeal membrane oxygenation. Radiology 2008; 248: 233-239
76 Kilian AK, Büsing K-A, Schuetz E-M et al. Fetal MR lung volumetry in congenital diaphragmatic hernia (CDH): prediction of clinical outcome and the need for extracorporeal membrane oxygenation (ECMO). Klin Padiatr 2009; 221: 295-301
77 Bohn D. Congenital diaphragmatic hernia. Am J Respir Crit Care Med 2002; 166: 911-915
78 Edelstone DI, Rudolph AM. Preferential streaming of ductus venosus blood to the brain and heart in fetal lambs. Am J Physiol 1979; 237: H724-H729
79 Rudolph A. Congenital Diseases of the Heart. Wiley-Blackwell; 2011
80 Soregaroli M, Rizzo G, Danti L et al. Effects of maternal hyperoxygenation on ductus venosus flow velocity waveforms in normal third-trimester fetuses. Ultrasound Obstet Gynecol 1993; 3: 115-119
81 Sherer DM, Fromberg RA, Divon MY. Prenatal ultrasonographic assessment of the ductus venosus: a review. Obstet Gynecol 1996; 88: 626-632
82 Kiserud T, Acharya G. The fetal circulation. Prenat Diagn 2004; 24: 1049-1059
83 Schmidt KG, Silverman NH, Rudolph AM. Assessment of flow events at the ductus venosus-inferior vena cava junction and at the foramen ovale in fetal sheep by use of multimodal ultrasound. Circulation 1996; 93: 826-833
84 Bellotti M, Pennati G, De Gasperi C et al. Role of ductus venosus in distribution of umbilical blood flow in human fetuses during second half of pregnancy. Am J Physiol Heart Circ Physiol 2000; 279: H1256-H1263
85 Stressig R, Fimmers R, Eising K et al. Preferential streaming of the ductus venosus and inferior caval vein towards the right heart is associated with left heart underdevelopment in human fetuses with left-sided diaphragmatic hernia. Heart [Internet] 2010; 96: 1564-1568 Available from http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20702536&retmode=ref&cmd=prlinks
86 Stressig R, Axt-Fliedner R, Gembruch U et al. Preferential Ductus Venosus Streaming Toward the Right Heart Is Associated with Left Heart Underdevelopment and Aortic Arch Hypoplasia in Human Fetuses. Ultraschall in Med 2011; 32: E115-E121
87 Guarino N, Shima H, Puri P. The hypoplastic heart in congenital diaphragmatic hernia: reduced expression of basic fibroblast growth factor and platelet-derived growth factor. Ped Surgery Int 2000; 16: 243-246
88 Karamanoukian HL, Glick PL, Wilcox DT et al. Pathophysiology of congenital diaphragmatic hernia. XI: Anatomic and biochemical characterization of the heart in the fetal lamb CDH model. Journal of Pediatric Surgery 1995; 30: 925-928 discussion 929
89 Karamanoukian HL, O’Toole SJ, Glick PL. “State-of-the-art” management strategies for the fetus and neonate with congenital diaphragmatic hernia. J Perinatol 1996; 16 (Suppl. 02) S40-S47
90 Migliazza L, Xia H, Alvarez JI et al. Heart hypoplasia in experimental congenital diaphragmatic hernia. Journal of Pediatric Surgery 1999; 34: 706-710 discussion710–711
91 Siebert JR, Haas JE, Beckwith JB. Left ventricular hypoplasia in congenital diaphragmatic hernia. Journal of Pediatric Surgery 1984; 19: 567-571
92 Grossfeld PD. Hypoplastic left heart syndrome: it is all in the genes. J Am Coll Cardiol 2007; 50: 1596-1597
93 Grossfeld P. Hypoplastic left heart syndrome: new insights. Circ Res 2007; 100: 1246-1248
94 Stressig R, Fimmers R, Axt-Fliedner R et al. Association of intrathoracic herniation of the liver with left heart hypoplasia in fetuses with a left diaphragmatic hernia but not in fetuses with a right diaphragmatic hernia. Ultraschall in Med 2011; 32 (Suppl. 02) E151-E156
95 Stressig R, Fimmers R, Eising K et al. Intrathoracic herniation of the liver (“liver-up”) is associated with predominant left heart hypoplasia in human fetuses with left diaphragmatic hernia. Ultrasound Obstet Gynecol 2011; 37: 272-276
96 Stressig R, Fimmers R, Schaible T et al. Preferential Streaming of the Ductus Venosus Toward the Right Atrium Is Associated With a Worse Outcome Despite a Higher Rate of Invasive Procedures in Human Fetuses With Left Diaphragmatic Hernia. Ultraschall Med 2013; 35: 1-5
97 Kohl T, Stressig R. Preferential ductus venosus streaming towards the right side of the heart may contribute to poorer outcomes in fetuses with left diaphragmatic hernia and intrathoracic liver herniation (“liver-up”). Ultrasound Obstet Gynecol 2010; 36: 259-
98 Rasanen J, Wood DC, Weiner S et al. Role of the pulmonary circulation in the distribution of human fetal cardiac output during the second half of pregnancy. Circulation 1996; 94: 1068-1073
99 Rasanen J, Wood DC, Debbs RH et al. Reactivity of the human fetal pulmonary circulation to maternal hyperoxygenation increases during the second half of pregnancy: a randomized study. Circulation 1998; 97: 257-262
100 Kohl T, Franz A, Geipel A et al. Abnormal ductus venosus streaming toward the right heart is associated with low pulmonary blood flow and vascular reactivity anomalies in human fetuses with left diaphragmatic hernia. Ultraschall in Med 2008; 29: 87-88
101 O’Toole SJ, Karamanoukian HL, Glick PL. Cardiopulmonary consequences of congenital diaphragmatic hernia. J Perinatol 1996; 16 (2 Pt 2 su) S34-S39
102 Kitano Y, Kanai M, Davies P et al. BAPS prize-1999: Lung growth induced by prenatal tracheal occlusion and its modifying factors: a study in the rat model of congenital diaphragmatic hernia. Journal of Pediatric Surgery 2001; 36: 251-259
103 Heerema AE, Rabban JT, Sydorak RM et al. Lung pathology in patients with congenital diaphragmatic hernia treated with fetal surgical intervention, including tracheal occlusion. Pediatr Dev Pathol 2003; 6: 536-546
104 Kohl T, Geipel A, Tchatcheva K et al. Life-saving effects of fetal tracheal occlusion on pulmonary hypoplasia from preterm premature rupture of membranes. Obstet Gynecol 2009; 113 (Suppl. 02) 480-483
105 Davey MG, Hooper SB, Tester ML et al. Respiratory function in lambs after in utero treatment of lung hypoplasia by tracheal obstruction. J Appl Physiol 1999; 87: 2296-2304
106 Harrison MR, Adzick NS, Flake AW et al. Correction of congenital diaphragmatic hernia in utero: VI. Hard-earned lessons. Journal of Pediatric Surgery. 1993. 28. 1411-1417 discussion1417–1418
107 Hedrick MH, Estes JM, Sullivan KM et al. Plug the lung until it grows (PLUG): a new method to treat congenital diaphragmatic hernia in utero. Journal of Pediatric Surgery 1994; 29: 612-617
108 Harrison MR, Adzick NS, Bullard KM et al. Correction of congenital diaphragmatic hernia in utero VII: a prospective trial. Journal of Pediatric Surgery 1997; 32: 1637-1642
109 Deprest JA, Nicolaides KH. FETO Task Group . Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia: evolution of a technique and preliminary results. Ultrasound Obstet Gynecol 2004; 24: 121-126
110 Deprest J, Jani J, Gratacos E et al. Fetal intervention for congenital diaphragmatic hernia: the European experience. Seminars in Perinatology 2005; 29: 94-103
111 Deprest J, Jani J, Cannie M et al. Prenatal intervention for isolated congenital diaphragmatic hernia. Curr Opin Obstet Gynecol 2006; 18: 355-367
112 Jani J, Valencia C, Cannie M et al. Tracheal diameter at birth in severe congenital diaphragmatic hernia treated by fetal endoscopic tracheal occlusion. Prenat Diagn 2011; 31: 699-704
113 Flageole H, Evrard VA, Piedboeuf B et al. The plug-unplug sequence: an important step to achieve type II pneumocyte maturation in the fetal lamb model. Journal of Pediatric Surgery 1998; 33: 299-303
114 Kohl T, Gembruch U, Filsinger B et al. Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias. Fetal Diagn Ther 2006; 21: 314-318
115 Davey MG, Hedrick HL, Bouchard S et al. Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function. J Appl Physiol 2003; 94: 1054-1062
116 Jani JC, Nicolaides KH, Gratacos E et al. Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion. Ultrasound Obstet Gynecol 2009; 34: 304-310
117 Schaible T, Hermle D, Loersch F et al. A 20-year experience on neonatal extracorporeal membrane oxygenation in a referral center. Intensive Care Med 2010; 36: 1229-1234
118 Peralta CFA, Sbragia L, Bennini JR et al. Fetoscopic endotracheal occlusion for severe isolated diaphragmatic hernia: initial experience from a single clinic in Brazil Fetal. Diagn Ther 2011; 29: 71-77
119 Stressig R, Kozlowski P, Froehlich S et al. Assessment of the ductus venosus, tricuspid blood flow and the nasal bone in second-trimester screening for trisomy 21. Ultrasound Obstet Gynecol 2011; 37: 444-449
120 Moya FR, Lally KP. Evidence-based management of infants with congenital diaphragmatic hernia. Seminars in Perinatology 2005; 29: 112-117
121 Wilson JM, Lund DP, Lillehei CW et al. Congenital diaphragmatic hernia – a tale of two cities: the Boston experience. Journal of Pediatric Surgery 1997; 32: 401-405
122 Migliazza L, Bellan C, Alberti D et al. Retrospective study of 111 cases of congenital diaphragmatic hernia treated with early high-frequency oscillatory ventilation and presurgical stabilization. Journal of Pediatric Surgery 2007; 42: 1526-1532
123 Bargy F, Beaudoin S, Barbet P. Fetal lung growth in congenital diaphragmatic hernia. Fetal Diagn Ther 2006; 21: 39-44
124 De Luca D, Daniele DL, Zecca E et al. Transient effect of epoprostenol and sildenafil combined with iNO for pulmonary hypertension in congenital diaphragmatic hernia. Paediatr Anaesth 2006; 16: 597-598
125 Logan JW, Rice HE, Goldberg RN et al. Congenital diaphragmatic hernia: a systematic review and summary of best-evidence practice strategies. J Perinatol 2007; 27: 535-549
126 Kays DW, Langham MR, Ledbetter DJ et al. Detrimental effects of standard medical therapy in congenital diaphragmatic hernia. Ann Surg 1999; 230: 340-348 – discussion 348–351
127 Downard CD, Jaksic T, Garza JJ et al. Analysis of an improved survival rate for congenital diaphragmatic hernia. Journal of Pediatric Surgery 2003; 38: 729-732
128 Bryner BS, West BT, Hirschl RB et al. Congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation: does timing of repair matter?. Journal of Pediatric Surgery 2009; 44: 1165-1171 – discussion 1171–1172
129 Baraldi E, Filippone M. Chronic lung disease after premature birth. N Engl J Med 2007; 357: 1946-1955