Int J Sports Med 2014; 35(12): 982-986
DOI: 10.1055/s-0034-1372635
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Prior Maximal Exercise Decreases Pulmonary Diffusing Capacity during Subsequent Exercise

J. C. Baldi
1   Medicine, University of Otago, Dunedin, New Zealand
,
M. J. Dacey
2   Biological Sciences, Northern Arizona University, Flagstaff, United States
,
M. J. Lee
2   Biological Sciences, Northern Arizona University, Flagstaff, United States
,
J. R. Coast
2   Biological Sciences, Northern Arizona University, Flagstaff, United States
› Author Affiliations
Further Information

Publication History



accepted after revision 24 February 2014

Publication Date:
16 May 2014 (online)

Abstract

Pulmonary diffusion (DLCO) increases during exercise due to greater pulmonary capillary volume (Vc) and membrane diffusing capacity (DM). However, after heavy exercise there is a reduction in resting DLCO. It is unclear whether this post-exercise effect will attenuate the normal increase in DLCO, Vc and DM during subsequent exercise and whether this affects SpO2 (pulse oximeter). DLCO, Vc, DM, cardiac output and SpO2 were measured at rest, moderate (~70% VO2peak) and heavy (~90 VO2peak) exercise in 9 subjects during 2 sessions separated by ~90 min. DLCO, Vc and DM increased during exercise (P<0.05). DLCO (P<0.05) and Vc (P<0.10), but not DM or SpO2 were lower in session 2 compared to the first. Reductions in DLCO and Vc appeared to be smallest during rest (1–4%) and greatest at high-intensity exercise (8–20%), but the interaction was not significant. SpO2 decreased by 4.9% and 5.1% from rest to high-intensity exercise during the first and second exercise bout, but these changes were not different. These data confirm that a bout of high-intensity exercise reduces DLCO and Vc, and may indicate that these changes are exacerbated during subsequent high-intensity exercise. Despite these changes, SpO2 was not affected by previous exercise.

 
  • References

  • 1 Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF, Dempsey JA. Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 2006; 575: 937-952
  • 2 Baldi JC, Cassuto NA, Foxx-Lupo WT, Wheatley CM, Snyder EM. Glycemic status affects cardiopulmonary exercise response in athletes with type 1 diabetes. Med Sci Sport Exerc 2010; 42: 1454-1459
  • 3 Ceridon ML, Beck KC, Olson TP, Bilezikian JA, Johnson BD. Calculating alveolar capillary conductance and pulmonary capillary blood volume: comparing the multiple- and single-inspired oxygen tension methods. J Appl Physiol 2010; 109: 643-653
  • 4 Dempsey JA, Hanson PG, Henderson KS. Exercise-induced arterial hypoxaemia in healthy human subjects at sea level. J Physiol 1984; 355: 161-175
  • 5 Hanel B, Clifford PS, Secher NH. Restricted post-exercise pulmonary diffusion does not impair maximal transport for O2 . J Appl Physiol 1994; 77: 2408-2412
  • 6 Hanel B, Law I, Mortensen J. Maximal rowing has an acute effect on the blood-gas barrier in elite athletes. J Appl Physiol 2003; 95: 1076-1082
  • 7 Hanel B, Teunissen I, Rabol A, Warberg J, Secher NH. Restricted post-exercise pulmonary diffusion capacity and central blood volume depletion. J Appl Physiol 1997; 83: 11-17
  • 8 Hankinson JL, Odendrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. Population. Am J Respir Crit Care Med 1999; 159: 179-187
  • 9 Harms CA, Babcock MA, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, Dempsey JA. Respiratory muscle work compromises leg blood flow during maximal exercise. J Appl Physiol 1997; 1573-1583
  • 10 Harriss DL, Atkinson G. Update – ethical standards in sport and exercise science research: 2014 update. Int J Sports Med 2013; 34: 1025-1028
  • 11 Hodges ANH, Mayo JR, McKenzie DC. Pulmonary oedema following exercise in humans. Sports Med 2006; 36: 501-512
  • 12 Hopkins SR, Schoene RB, Henderson WR, Spragg RG, West JB. Sustained submaximal exercise does not alter the integrity of the lung blood-gas barrier in elite athletes. J Appl Physiol 1998; 84: 1185-1189
  • 13 Hopkins SR, Schone RB, Henderson WR, Spragg RG, Martin TR, West JB. Intense exercise impairs the integrity of pulmonary blood-gas barrier in elite athletes. Am J Respir Crit Care Med 1997; 151: 1090-1094
  • 14 Johns DP, Berry D, Maskrey M, Wood-Baker R, Reid DW, Walters EH, Walls J. Decreased lung capillary blood volume post-exercise is compensated by increased membrane diffusing capacity. Eur J Appl Physiol 2004; 93: 96-101
  • 15 Johnson Jr RL. Pulmonary diffusion as a limiting factor in exercise stress. Circ Res 1967; 20: I-154-I-160
  • 16 Johnson Jr RL, Spicer WS, Bishop JM, Forster RE. Pulmonary capillary blood volume, flow and diffusing capacity during exercise. J Appl Physiol 1960; 15: 893-902
  • 17 Manier G, Moinard J, Stoicheff H. Pulmonary diffusing capacity after maximal exercise. J Appl Physiol 1993; 75: 2580-2585
  • 18 Manier G, Moinard J, Techoueyres P, Varene N, Guenard H. Pulmonary diffusion limitation after prolonged strenuous exercise. Respir Physiol 1991; 83: 143-154
  • 19 McKenzie DC, Lama IL, Potts JE, Sheel AW, Coutts KD. The effect of repeated exercise on pulmonary diffusing capacity and EIH in trained athletes. Med Sci Sports Exerc 1999; 31: 99-104
  • 20 Miles DS, Doerr CE, Schoenfelf SA, Sinks DE, Gotshall RW. Changes in pulmonary diffusing capacity and closing volume after running a marathon. Respir Physiol 1983; 52: 349-359
  • 21 Nagashima K, Mack GW, Haskell A, Nishiyasu T, Nadel ER. Mechanism for the posture-specific plasma volume increase after a single intense exercise protocol. J Appl Physiol 1999; 86: 867-873
  • 22 Niranjan V, McBrayer DG, Ramirez LC, Raskin P, Hsia CC. Glycemic control and cardiopulmonary function in patients with insulin-dependent diabetes mellitus. Am J Med 1997; 103: 504-513
  • 23 Olson LJ, Snyder EM, Beck KC, Johnson BD. Reduced rate of alveolar-capillary recruitment and fall of pulmonary diffusing capacity during exercise in patients with heart failure. J Cardiac Fail 2006; 12: 299-306
  • 24 Rasmussen BD, Hanel B, Jenson K, Serup B, Secher NH. Decrease in pulmonary diffusion capacity after maximal exercises. J Sports Sci 1986; 4: 185-188
  • 25 Rasmussen BD, Elkjaer P, Juhl B. Impaired pulmonary and cardiac function after maximal exercise. J Sports Sci 1988; 6: 219-228
  • 26 Rasmussen BD, Hanel B, Saunamaki K, Secher NH. Recovery of pulmonary diffusing capacity after maximal exercise. J Sports Sci 1992; 10: 525-531
  • 27 Roughton FJW, Forster RE. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J Appl Physiol 1957; 11: 290-302
  • 28 Romer LM, Haverkamp HC, Lovering AT, Pegelow DF, Dempsey JA. Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans. Am J Physiol 2006; 2290: R365-R375
  • 29 Rowell LB. Human Circulation Regulation During Physical Stress. NY: Oxford University Press; 1986
  • 30 Sheel AW, Coutts KD, Potts JE, McKenzie DC. The time course of pulmonary diffusing capacity for carbon monoxide following short duration high intensity exercise. Respir Physiol 1998; 111: 271-281
  • 31 Wheatley CM, Baldi JC, Cassuto NA, Foxx-Lupo WT, Snyder EM. Glycemic control influences lung membrane diffusion and oxygen saturation in exercise-trained subjects with type 1 diabetes. Eur J Appl Physiol 2011; 111: 567-578