Articles from Seminars in Thrombosis & Hemostasis (STH) Archives^[*]

As a part of this very special issue of Seminars in Thrombosis & Hemostasis, we have provided access through this Appendix to four articles previously published in this journal.[1] [2] [3] [4]

These articles hold special relevance to this issue of the journal, as extensively highlighted within the Preface to this issue. Seminars in Thrombosis & Hemostasis began publishing 40 years ago in 1974 under the stewardship of Eberhard F. Mammen, the founding Editor-in-Chief of the journal.

In a fitting tribute to Dr. Mammen, we began this celebratory issue with a new contribution on the topic of “Sticky platelet syndrome”, as this topic was of major interest to him, as evidenced by both the new contribution as well as by the reproduction of one of his articles on this topic in this journal in 1999.[1]

Several contributions within this issue of the journal are related to von Willebrand factor (VWF), Factor VIIII (FVIII), von Willebrand disease (VWD), and hemophilia, and to various interrelationships. VWD is reportedly the most common bleeding disorder, and arises as a deficiency or defect in VWF. Sufferers of severe VWD, particularly type 3 VWD, also suffer from loss of FVIII, given that one role of VWF is to bind to and protect FVIII from degradation. Classical hemophilia is caused by the lack of specific coagulation factors, and notably hemophilia A is caused by a lack of FVIII. The historical context to what we now know to be true regarding these disorders and the proteins involved took several decades to evolve, and there was once considerable confusion regarding the relationship between the linked but separate molecules FVIII and VWF, and the respective disorders of hemophilia A and VWD. Some of this historical context is therefore highlighted within the Appendix with several historical reproductions.[2] [3]

Finally, we are now at cross-roads in hemophilia care, given the development of new and improved therapies. Nevertheless, universal access to care still remains imperfect, even today. Accordingly, the final historical piece within the Appendix[4] has been included to provide some historical context to life in the hemophilia world of the 1990s.

I hope that the readership of this journal finds these reproductions of interest.

^* Providing access to a collection of articles previously published in Seminars in Thrombosis & Hemostasis.

• References

• 1 Mammen EF. Sticky platelet syndrome. Semin Thromb Hemost 1999; 25 (4) 361-365 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-994939
• 2 Mammen EF. Von Willebrand's disease—history, diagnosis and management. Semin Thromb Hemost 1975; 2 (2) 61-84 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0028-1086116
• 3 Irwin JF. Factor VIII in von Willebrand' disease. Semin Thromb Hemost 1975; 2 (2) 85-104 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0028-1086117
• 4 Kasper CK, Mannucci PM, Bulyzhenkov V , et al. Hemophilia in the 1990s: principles of management and improved access to care. Semin Thromb Hemost 1992; 18 (1) 1-10 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-1002404