Hereditary Spastic Paraplegia: Clinical Principles and Genetic Advances

John K. Fink

doi:10.1055/s-0034-1386767

Seminars in Neurology, Inhaltsverzeichnis

Semin Neurol 2014; 34(03): 293-305
DOI: 10.1055/s-0034-1386767

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hereditary Spastic Paraplegia: Clinical Principles and Genetic Advances

John K. Fink

¹Department of Neurology, University of Michigan; Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan

› Institutsangaben

Abstract

Hereditary spastic paraplegia (HSP) refers to inherited disorders in which spastic gait is either the only feature or is a major syndrome feature. There are more than 70 genetic types of HSP. Neuropathological studies, albeit limited to only a few genetic types of HSP, have identified axon degeneration involving the distal ends of the corticospinal tracts and fasciculus gracilis fibers. In this review, the author highlights the clinical and genetic features of HSP.

Keywords

spastic paraplegia - hereditary - spinal cord - genetic

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Referenzen

References
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