The Status of Research into Resistance to Diet-Induced Obesity

C. Ding; J. Guo; Z. Su

doi:10.1055/s-0034-1395584

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2015; 47(06): 404-410
DOI: 10.1055/s-0034-1395584

Review

The Status of Research into Resistance to Diet-Induced Obesity

C. Ding

¹Key Research Center of Liver Regulation for Hyperlipidemia SATCM/Class III, Laboratory of Metabolism SATCM, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China

,

J. Guo

¹Key Research Center of Liver Regulation for Hyperlipidemia SATCM/Class III, Laboratory of Metabolism SATCM, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China

,

Z. Su

¹Key Research Center of Liver Regulation for Hyperlipidemia SATCM/Class III, Laboratory of Metabolism SATCM, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China

› Institutsangaben

Abstract

Obesity resistance is an increasingly popular area of study in academia, although the factors that lead to the occurrence of obesity resistance remain unclear. In this review, we discuss the currently known causes of obesity resistance. By comparing the differences between obesity-resistant individuals and obesity-susceptible individuals, researchers have identified the characteristics of obesity-resistant individuals. The primary approach has been to breed rats and mice with a high-fat diet and to compare the differences between obesity-resistant and obesity-susceptible individuals. The characterized differences have included gastrointestinal fat absorption, appetite, physical activity, fat storage, and fat consumption. Considerably more research is needed into the mechanisms of obesity resistance that could be used to lose weight among human subjects. However, there are few ongoing obesity resistance studies. Due to the relatively slow rate of development in this field, greater efforts must be applied in this area.

Key words

obesity - obesity resistance - fat absorption - appetite - physical activity

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References
1 Anderson PJ, Critchley JA, Chan JC, Cockram CS, Lee ZS, Thomas GN, Tomlinson B. Factor analysis of the metabolic syndrome: obesity vs. insulin resistance as the central abnormality. Int J Obes Relat Metab Disord 2001; 25: 1782-1788
2 Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993; 44: 121-131
3 Hebebrand J, Friedel S, Schauble N, Geller F, Hinney A. Perspectives: molecular genetic research in human obesity. Obes Rev 2003; 4: 139-146
4 Bandini LG, Vu D, Must A, Cyr H, Goldberg A, Dietz WH. Comparison of high-calorie, low-nutrient-dense food consumption among obese and non-obese adolescents. Obes Res 1999; 7: 438-443
5 Mutch DM, Clement K. Unraveling the genetics of human obesity. PLoS Genet 2006; 2: e188
6 Stubbs RJ, Hughes DA, Johnstone AM, Horgan GW, King N, Blundell JE. A decrease in physical activity affects appetite, energy, and nutrient balance in lean men feeding ad libitum. Am J Clin Nutr 2004; 79: 62-69
7 Boozer CN, Leibel RL, Love RJ, Cha MC, Aronne LJ. Synergy of sibutramine and low-dose leptin in treatment of diet-induced obesity in rats. Metabolism 2001; 50: 889-893
8 Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O’Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908
9 Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401
10 Bell CG, Walley AJ, Froguel P. The genetics of human obesity. Nat Rev Genet 2005; 6: 221-234
11 Ridderstrale M, Groop L. Genetic dissection of type 2 diabetes. Mol Cell Endocrinol 2009; 297: 10-17
12 Isaac M. Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Curr Top Med Chem 2005; 5: 59-67
13 Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999; 38: 1083-1152
14 Price RD, Sanders-Bush E. RNA editing of the human serotonin 5-HT(2C) receptor delays agonist-stimulated calcium release. Mol Pharmacol 2000; 58: 859-862
15 Werry TD, Loiacono R, Sexton PM, Christopoulos A. RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 2008; 119: 7-23
16 Higgins GA, Sellers EM, Fletcher PJ. From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists. Trends Pharmacol Sci 2013; 34: 560-570
17 Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 1997; 387: 303-308
18 Levin BE, Dunn-Meynell AA, Balkan B, Keesey RE. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol 1997; 273: R725-R730
19 Levin BE, Dunn-Meynell AA. In vivo and in vitro regulation of [3H]glyburide binding to brain sulfonylurea receptors in obesity-prone and resistant rats by glucose. Brain Res 1997; 776: 146-153
20 Levin BE, Keesey RE. Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol 1998; 274: R412-R419
21 Levin BE, Dunn-Meynell AA. Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats. Am J Physiol Regul Integr Comp Physiol 2000; 278: R231-R237
22 Ricci MR, Levin BE. Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 2003; 285: R610-R618
23 Levin BE, Magnan C, Migrenne S, Chua SJ, Dunn-Meynell AA. F-DIO obesity-prone rat is insulin resistant before obesity onset. Am J Physiol Regul Integr Comp Physiol 2005; 289: R704-R711
24 Levin BE, Dunn-Meynell AA. Differential effects of exercise on body weight gain and adiposity in obesity-prone and -resistant rats. Int J Obes (Lond) 2006; 30: 722-727
25 Patterson CM, Dunn-Meynell AA, Levin BE. Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation. Am J Physiol Regul Integr Comp Physiol 2008; 294: R290-R301
26 Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Tang-Christensen M, Hansen HS, Levin BE, Larsen PJ, Knudsen LB, Fosgerau K, Vrang N. Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome. J Endocrinol 2010; 206: 287-296
27 Primeaux SD, Braymer HD, Bray GA. CD36 mRNA in the gastrointestinal tract is differentially regulated by dietary fat intake in obesity-prone and obesity-resistant rats. Dig Dis Sci 2013; 58: 363-370
28 Sefcikova Z, Hajek T, Lenhardt L, Racek L, Mozes S. Different functional responsibility of the small intestine to high-fat/high-energy diet determined the expression of obesity-prone and obesity-resistant phenotypes in rats. Physiol Res 2008; 57: 467-474
29 Primeaux SD, Braymer HD, Bray GA. High fat diet differentially regulates the expression of olfactory receptors in the duodenum of obesity-prone and obesity-resistant rats. Dig Dis Sci 2013; 58: 72-76
30 Kondo H, Minegishi Y, Komine Y, Mori T, Matsumoto I, Abe K, Tokimitsu I, Hase T, Murase T. Differential regulation of intestinal lipid metabolism-related genes in obesity-resistant A/J vs. obesity-prone C57BL/6J mice. Am J Physiol Endocrinol Metab 2006; 291: E1092-E1099
31 Barnes MJ, Holmes G, Primeaux SD, York DA, Bray GA. Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity. Peptides 2006; 27: 3292-3298
32 Ishihara Y, White CL, Kageyama H, Kageyama A, York DA, Bray GA. Effects of diet and time of the day on serum and CSF leptin levels in Osborne-Mendel and S5B/Pl rats. Obes Res 2004; 12: 1067-1076
33 Lin L, York DA. Comparisons of the effects of enterostatin on food intake and gastric emptying in rats. Brain Res 1997; 745: 205-209
34 Lin L, Martin R, Schaffhauser AO, York DA. Acute changes in the response to peripheral leptin with alteration in the diet composition. Am J Physiol Regul Integr Comp Physiol 2001; 280: R504-R509
35 Liu X, York DA, Bray GA. Regulation of ghrelin gene expression in stomach and feeding response to a ghrelin analogue in two strains of rats. Peptides 2004; 25: 2171-2177
36 Madiehe AM, Schaffhauser AO, Braymer DH, Bray GA, York DA. Differential expression of leptin receptor in high- and low-fat-fed Osborne-Mendel and S5B/Pl rats. Obes Res 2000; 8: 467-474
37 Okada S, York DA, Bray GA, Mei J, Erlanson-Albertsson C. Differential inhibition of fat intake in two strains of rat by the peptide enterostatin. Am J Physiol 1992; 262: R1111-R1116
38 Ookuma K, Barton C, York DA, Bray GA. Differential response to kappa-opioidergic agents in dietary fat selection between Osborne-Mendel and S5B/P1 rats. Peptides 1998; 19: 141-147
39 Primeaux SD, Barnes MJ, Braymer HD, Bray GA. Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl rats. Int J Obes (Lond) 2010; 34: 1427-1433
40 Primeaux SD, Blackmon C, Barnes MJ, Braymer HD, Bray GA. Central administration of the RFamide peptides, QRFP-26 and QRFP-43, increases high fat food intake in rats. Peptides 2008; 29: 1994-2000
41 Schaffhauser AO, Madiehe AM, Braymer HD, Bray GA, York DA. Effects of a high-fat diet and strain on hypothalamic gene expression in rats. Obes Res 2002; 10: 1188-1196
42 Schemmel RA, Teague RJ, Bray GA. Obesity in Osborne-Mendel and S 5B/Pl rats: effects of sucrose solutions, castration, and treatment with estradiol or insulin. Am J Physiol 1982; 243: R347-R353
43 Thanos PK, Cho J, Kim R, Michaelides M, Primeaux S, Bray G, Wang GJ, Volkow ND. Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats. Behav Brain Res 2011; 217: 165-170
44 Thanos PK, Kim R, Cho J, Michaelides M, Anderson BJ, Primeaux SD, Bray GA, Wang GJ, Robinson JK, Volkow ND. Obesity-resistant S5B rats showed greater cocaine conditioned place preference than the obesity-prone OM rats. Physiol Behav 2010; 101: 713-718
45 White CL, Ishii Y, Mendoza T, Upton N, Stasi LP, Bray GA, York DA. Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity. Peptides 2005; 26: 2331-2338
46 Greenberg D, McCaffery J, Potack JZ, Bray GA, York DA. Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats. Physiol Behav 1999; 66: 621-626
47 Perez-Echarri N, Perez-Matute P, Martinez JA, Marti A, Moreno-Aliaga MJ. Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity. J Physiol Biochem 2005; 61: 333-342
48 Chandler PC, Viana JB, Oswald KD, Wauford PK, Boggiano MM. Feeding response to melanocortin agonist predicts preference for and obesity from a high-fat diet. Physiol Behav 2005; 85: 221-230
49 Bonen A, Holloway GP, Tandon NN, Han XX, McFarlan J, Glatz JF, Luiken JJ. Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 2009; 297: R1202-R1212
50 Moore KJ, El KJ, Medeiros LA, Terada K, Geula C. Luster AD, Freeman MW. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem 2002; 277: 47373-47379
51 Pittman DW, Smith KR, Crawley ME, Corbin CH, Hansen DR, Watson KJ, Gilbertson TA. Orosensory detection of fatty acids by obesity-prone and obesity-resistant rats: strain and sex differences. Chem Senses 2008; 33: 449-460
52 Abumrad NA. CD36 may determine our desire for dietary fats. J Clin Invest 2005; 115: 2965-2967
53 Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF, Silverstein RL. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 1999; 274: 19055-19062
54 Febbraio M, Guy E, Coburn C, Knapp FJ, Beets AL, Abumrad NA, Silverstein RL. The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. Mol Cell Biochem 2002; 239: 193-197
55 Gaillard D, Laugerette F, Darcel N, El-Yassimi A, Passilly-Degrace P, Hichami A, Khan NA, Montmayeur JP, Besnard P. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J 2008; 22: 1458-1468
56 Hajri T, Hall AM, Jensen DR, Pietka TA, Drover VA, Tao H, Eckel R, Abumrad NA. CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue. Diabetes 2007; 56: 1872-1880
57 Laugerette F, Passilly-Degrace P, Patris B, Niot I, Febbraio M, Montmayeur JP, Besnard P. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest 2005; 115: 3177-3184
58 Sclafani A, Ackroff K, Abumrad NA. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. Am J Physiol Regul Integr Comp Physiol 2007; 293: R1823-R1832
59 Hofer D, Puschel B, Drenckhahn D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA 1996; 93: 6631-6634
60 Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci USA 2007; 104: 15069-15074
61 Kokrashvili Z, Mosinger B, Margolskee RF. Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr 2009; 90: 822S-825S
62 Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci USA 2007; 104: 15075-15080
63 Chen M, Yang Y, Braunstein E, Georgeson KE, Harmon CM. Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes. Am J Physiol Endocrinol Metab 2001; 281: E916-E923
64 Martin C, Passilly-Degrace P, Gaillard D, Merlin JF, Chevrot M, Besnard P. The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference. PLoS One 2011; 6: e24014
65 Simons PJ, Boon L. Lingual CD36 and obesity: a matter of fat taste?. Acta Histochem 2011; 113: 765-767 768–769
66 Simons PJ, Kummer JA, Luiken JJ, Boon L. Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae. Acta Histochem 2011; 113: 839-843
67 Zhang XJ, Zhou LH, Ban X, Liu DX, Jiang W, Liu XM. Decreased expression of CD36 in circumvallate taste buds of high-fat diet induced obese rats. Acta Histochem 2011; 113: 663-667
68 Khan NA, Besnard P. Oro-sensory perception of dietary lipids: new insights into the fat taste transduction. Biochim Biophys Acta 2009; 1791: 149-155
69 El-Yassimi A, Hichami A, Besnard P, Khan NA. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. J Biol Chem 2008; 283: 12949-12959
70 Gaillard D, Passilly-Degrace P, Besnard P. Molecular mechanisms of fat preference and overeating. Ann N Y Acad Sci 2008; 1141: 163-175
71 Mizushige T, Inoue K, Fushiki T. Why is fat so tasty? Chemical reception of fatty acid on the tongue. J Nutr Sci Vitaminol (Tokyo) 2007; 53: 1-4
72 Mustelin L, Silventoinen K, Pietilainen K, Rissanen A, Kaprio J. Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins. Int J Obes (Lond) 2009; 33: 29-36
73 Hamilton MT, Hamilton DG, Zderic TW. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 2007; 56: 2655-2667
74 Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, Dussault J, Moorjani S, Pinault S, Fournier G. The response to long-term overfeeding in identical twins. N Engl J Med 1990; 322: 1477-1482
75 Forbes GB, Brown MR, Welle SL, Lipinski BA. Deliberate overfeeding in women and men: energy cost and composition of the weight gain. Br J Nutr 1986; 56: 1-9
76 Levine JA, Lanningham-Foster LM, McCrady SK, Krizan AC, Olson LR, Kane PH, Jensen MD, Clark MM. Interindividual variation in posture allocation: possible role in human obesity. Science 2005; 307: 584-586
77 Levine JA. Non-exercise activity thermogenesis (NEAT). Best Pract Res Clin Endocrinol Metab 2002; 16: 679-702
78 Levine JA, Eberhardt NL, Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 1999; 283: 212-214
79 Fruhbeck G. Does a NEAT difference in energy expenditure lead to obesity?. Lancet 2005; 366: 615-616
80 Ravussin E. Physiology. A NEAT way to control weight?. Science 2005; 307: 530-531
81 Snitker S, Tataranni PA, Ravussin E. Spontaneous physical activity in a respiratory chamber is correlated to habitual physical activity. Int J Obes Relat Metab Disord 2001; 25: 1481-1486
82 Garland TJ, Schutz H, Chappell MA, Keeney BK, Meek TH, Copes LE, Acosta W, Drenowatz C, Maciel RC, van Dijk G, Kotz CM, Eisenmann JC. The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. J Exp Biol 2011; 214: 206-229
83 Kotz CM, Wang C, Teske JA, Thorpe AJ, Novak CM, Kiwaki K, Levine JA. Orexin A mediation of time spent moving in rats: neural mechanisms. Neuroscience 2006; 142: 29-36
84 Dishman RK. Gene-physical activity interactions in the etiology of obesity: behavioral considerations. Obesity (Silver Spring) 2008; 16 (Suppl. 03) S60-S65
85 Teske JA, Billington CJ, Kotz CM. Neuropeptidergic mediators of spontaneous physical activity and non-exercise activity thermogenesis. Neuroendocrinology 2008; 87: 71-90
86 Teske JA, Levine AS, Kuskowski M, Levine JA, Kotz CM. Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant rats. Am J Physiol Regul Integr Comp Physiol 2006; 291: R889-R899
87 Nehrenberg DL, Hua K, Estrada-Smith D, Garland TJ, Pomp D. Voluntary exercise and its effects on body composition depend on genetic selection history. Obesity (Silver Spring) 2009; 17: 1402-1409
88 Swallow JG, Wroblewska AK, Waters RP, Renner KJ, Britton SL, Koch LG. Phenotypic and evolutionary plasticity of body composition in rats selectively bred for high endurance capacity. J Appl Physiol 2010; 109: 778-785
89 Haskell-Luevano C, Schaub JW, Andreasen A, Haskell KR, Moore MC, Koerper LM, Rouzaud F, Baker HV, Millard WJ, Walter G, Litherland SA, Xiang Z. Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. FASEB J 2009; 23: 642-655
90 Levin BE, Dunn-Meynell AA. Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 2004; 286: R771-R778
91 Bi S, Scott KA, Hyun J, Ladenheim EE, Moran TH. Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling. Endocrinology 2005; 146: 1676-1685
92 Moore LL, Gao D, Bradlee ML, Cupples LA, Sundarajan-Ramamurti A, Proctor MH, Hood MY, Singer MR, Ellison RC. Does early physical activity predict body fat change throughout childhood?. Prev Med 2003; 37: 10-17
93 Janz KF, Kwon S, Letuchy EM, Eichenberger GJ, Burns TL, Torner JC, Willing MC, Levy SM. Sustained effect of early physical activity on body fat mass in older children. Am J Prev Med 2009; 37: 35-40
94 Kotz CM, Teske JA, Billington CJ. Neuroregulation of nonexercise activity thermogenesis and obesity resistance. Am J Physiol Regul Integr Comp Physiol 2008; 294: R699-R710
95 Westerterp KR, Speakman JR. Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals. Int J Obes (Lond) 2008; 32: 1256-1263
96 Monasta L, Batty GD, Cattaneo A, Lutje V, Ronfani L, Van Lenthe FJ, Brug J. Early-life determinants of overweight and obesity: a review of systematic reviews. Obes Rev 2010; 11: 695-708
97 Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18: 9996-10015
98 Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 1-696
99 de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FN, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 1998; 95: 322-327
100 Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001; 30: 345-354
101 Kotz C, Nixon J, Butterick T, Perez-Leighton C, Teske J, Billington C. Brain orexin promotes obesity resistance. Ann N Y Acad Sci 2012; 1264: 72-86
102 Perrin D, Mamet J, Geloen A, Morel G, Dalmaz Y, Pequignot JM. Sympathetic and brain monoaminergic regulation of energy balance in obesity-resistant rats (Lou/C). Auton Neurosci 2003; 109: 1-9
103 Danner FW. A national longitudinal study of the association between hours of TV viewing and the trajectory of BMI growth among US children. J Pediatr Psychol 2008; 33: 1100-1107
104 Mavanji V, Teske JA, Billington CJ, Kotz CM. Elevated sleep quality and orexin receptor mRNA in obesity-resistant rats. Int J Obes (Lond) 2010; 34: 1576-1588
105 Zhang HL, Zhong XB, Tao Y, Wu SH, Su ZQ. Effects of chitosan and water-soluble chitosan micro- and nanoparticles in obese rats fed a high-fat diet. Int J Nanomedicine 2012; 7: 4069-4076
106 Zhang HL, Tao Y, Guo J, Hu YM, Su ZQ. Hypolipidemic effects of chitosan nanoparticles in hyperlipidemia rats induced by high fat diet. Int Immunopharmacol 2011; 11: 457-461