Zelltherapie in der Rheumatologie: Chancen und Risiken der Therapie mit mesenchymalen Stromazellen ^[*]

Schlüsselwörter

mesenchymale Stromazellen (MSC) - Immunmodulation - Systemische Sklerose - Rheumatoide Arthritis

Key words

mesenchymal stromal cells - immune modulation - systemic sclerosis - rheumatoid arthritis

^* Dieser Artikel ist zuerst erschienen in Dtsch Med Wochenschr 2013; 138: 1852–1855.

• Literatur

• 1 Aurich I, Mueller LP, Aurich H et al. Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers. Gut 2007; 56: 405
• 2 Bieback K, Wuchter P, Besser D et al. Mesenchymal stromal cells (MSCs): science and friction. J Mol Med 2012; 90: 773-782
• 3 Bocelli-Tyndall C, Zajac P, Di Maggio N et al. Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells. Arthritis Rheum 2010; 62: 3815-3825
• 4 Bouffi C, Bony C, Courties G et al. IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis. PLoS ONE 2010; 5: e14247
• 5 Carrion F, Nova E, Ruiz C et al. Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Lupus 2010; 19: 317-322
• 6 Crisan M, Yap S, Casteilla L et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008; 3: 301-313
• 7 Dazzi F, van Laar JM, Cope A et al. Cell therapy for autoimmune diseases. Arth Res Ther 2007; 9: 206
• 8 Dominici M, Le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-317
• 9 Greenbaum A, Hsu YS, Day RB et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 2013; 495: 227-230
• 10 Gu Z, Akiyama K, Ma X et al. Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice. Lupus 2010; 19: 1502-1514
• 11 Guiducci S, Manetti M, Romano E et al. Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro. Ann Rheum Dis 2011; 70: 2011-2021
• 12 Ho AD, Wagner W, Franke W. Heterogeneity of mesenchymal stromal cell preparations. Cytotherapy 2008; 10: 320-330
• 13 Keyßer G, Christopeit M, Fick S et al. Treatment of severe progressive systemic sclerosis with transplantation of mesenchymal stromal cells from allogeneic related donors: report of five cases. Arthritis Rheum 2011; 63: 2540-2542
• 14 Le Blanc K, Mougiakakos D. Multipotent meenchymal stromal cells and the innate immune system. Nature Reviews 2012; 12: 383-396
• 15 Liang J, Zhang H, Hua B et al. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 2010; 69: 1423-1429
• 16 Luria EA, Panasyuk AF, Friedenstein AY. Fibroblast colony formation from monolayer cultures of blood cells. Transfusion 1971; 11: 345-349
• 17 MacDonald GIA, Augello A, De Bari C. Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases. Arthritis Rheum 2011; 63: 2547-2557
• 18 Mendez-Ferrer S, Michurina TV, Ferraro F et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010; 466: 829-834
• 19 Mougiakakos D, Jitschin R, Johansson CC et al. The impact of inflammatory licensing on heme oxygenase- 1- mediated induction of regulatory T cells by human Mesenchymal stem cells. Blood 2011; 117: 4826-4835
• 20 Mueller LP, Luetzkendorf J, Mueller T et al. Presence of Mesenchymal Stem Cells in Human Bone Marrow After Exposure to Chemotherapy: Evidence of Resistance to Apoptosis Induction. Stem Cells 2006; 24: 2753-2765
• 21 Murphy JM, Dixon K, Beck S et al. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum 2002; 46: 704-713
• 22 Németh K, Leelahavanichkul A, Yuen PST et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production. Nature Medicine 2009; 15: 42-49
• 23 Petrie Aronin CE, Tuan RS. Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells. Birth Defects Res C Embryo Today 2010; 90: 67-74
• 24 Prigione I, Benvenuto F, Bocca P et al. Reciprocal interactions between human mesenchymal stem cells and γδ T cells or invariant natural killer T cells. Stem Cells 2009; 27: 693-702
• 25 Sugiyama T, Kohara H, Noda M et al. Maintenance of the hematopoietic stem cell pool by CXCL12–CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006; 25: 977-988
• 26 Sun L, Akiyama K, Zhang H et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009; 27: 1421-1432
• 27 Sun L, Wang D, Liang J et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 2010; 62: 2467-2475
• 28 Tyndall A, Furst ED. Adult stem cell treatment of scleroderma. Curr Opin Rheumatol 2007; 19: 604-610
• 29 Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nature Rev Immunol 2008; 8: 726-736
• 30 von Bahr L, Batsis I, Moll G et al. Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited longterm engraftment and no ectopic tissue formation. Stem Cells 2012; 30: 1575-1578
• 31 Wagner W, Feldmann Jr RE, Seckinger A et al. The heterogeneity of human mesenchymal stem cell preparations--evidence from simultaneous analysis of proteomes and transcriptom. Exp Hematol 2006; 34: 536-548
• 32 Wagner W, Roderburg C, Wein F et al. Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors. Stem Cells 2007; 25: 2638-2647
• 33 Wuchter P, Boda-Heggemann J, Straub BK et al. Processus and recessus adhaerentes: giant adherens cell junction systems connect and attract human mesenchymal stem cells. Cell Tissue Res 2007; 328: 499-514
• 34 Xu J, Wang D, Liu D et al. Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome. Blood 2012; 120: 3142-3151
• 35 Zhou K, Zhang H, Jin O et al. Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice. Cell Mol Immunol 2008; 5: 417-424