Semin Neurol 2014; 34(05): 496-503
DOI: 10.1055/s-0034-1396003
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Rehabilitation of Poststroke Cognition

Cheryl L. Shigaki
1   Department of Health Psychology, University of Missouri, Columbia, Missouri
,
Scott H. Frey
2   Department of Psychological Sciences and Brain Imaging Center, University of Missouri, Columbia, Missouri
,
A.M. Barrett
3   Stroke Rehabilitation Research, Kessler Foundation, West Orange, New Jersey
4   Department of Physical Medicine and Rehabilitation, Rutgers University of New Jersey-NJ Medical School, 1199 Pleasant Valley Way, West Orange, New Jersey
› Author Affiliations
Further Information

Publication History

Publication Date:
17 December 2014 (online)

Abstract

Given the increasing rates of stroke and our aging population, it is critical that we continue to foster innovation in stroke rehabilitation. Although there is evidence supporting cognitive rehabilitation in stroke, the set of cognitive domains effectively addressed to date represents only a small subset of the problems experienced by stroke survivors. Further, a gap remains between investigational treatments and our evolving theories of brain function. These limitations present opportunities for improving the functional impact of stroke rehabilitation. The authors use a case example to encourage the reader to consider the evidence base for cognitive rehabilitation in stroke, focusing on four domains critical to daily life function: (1) speech and language, (2) functional memory, (3) executive function and skilled learned purposive movements, and (4) spatial-motor systems. Ultimately, they attempt to draw neuroscience and practice closer together by using translational reasoning to suggest possible new avenues for treating these disorders.

 
  • References

  • 1 Edwards DF, Hahn MG, Baum CM, Perlmutter MS, Sheedy C, Dromerick AW. Screening patients with stroke for rehabilitation needs: validation of the post-stroke rehabilitation guidelines. Neurorehabil Neural Repair 2006; 20 (1) 42-48
  • 2 Wilshire CE. Cognitive neuropsychological approaches to word production in aphasia: Beyond boxes and arrows. Aphasiology 2008; 22 (10) 1019-1053
  • 3 Albert ML, Goodglass H, Helm NA, Rubens AB, Alexander MP. Dysphasia without repetition disturbance. In: Clinical Aspects of Dysphasia. Vol 2. Heidelberg, Germany: Springer; 1981: 92-106
  • 4 Freedman M, Alexander MP, Naeser MA. Anatomic basis of transcortical motor aphasia. Neurology 1984; 34 (4) 409-417
  • 5 Fuster JM. Executive frontal functions. Exp Brain Res 2000; 133 (1) 66-70
  • 6 Mitchell KJ, Raye CL, Johnson MK, Greene EJ. An fMRI investigation of short-term source memory in young and older adults. Neuroimage 2006; 30 (2) 627-633
  • 7 Buxbaum LJ, Haaland KY, Hallett M , et al. Treatment of limb apraxia: moving forward to improved action. Am J Phys Med Rehabil 2008; 87 (2) 149-161
  • 8 McKenna C, Thakur U, Marcus B, Barrett AM. Assessing limb apraxia in traumatic brain injury and spinal cord injury. Front Biosci (Schol Ed) 2013; 5: 732-742
  • 9 Christensen AL. Luria's Neuropsychological Investigation. New York, NY: Spectrum; 1975
  • 10 Taylor HG, Heilman KM. Left-hemisphere motor dominance in righthanders. Cortex 1980; 16 (4) 587-603
  • 11 Basso A, Burgio F, Paulin M, Prandoni P. Long-term follow-up of ideomotor apraxia. Neuropsychol Rehabil 2000; 10 (1) 1-13
  • 12 Mimura M, Fitzpatrick PM, Albert ML. Long-term recovery from ideomotor apraxia. Neuropsychiatry Neuropsychol Behav Neurol. 1996; 9 (2) 127-132
  • 13 Adair JC, Barrett AM. Spatial neglect: clinical and neuroscience review: a wealth of information on the poverty of spatial attention. Ann N Y Acad Sci 2008; 1142 (1) 21-43
  • 14 Pedersen PM, Wandel A, Jørgensen HS, Nakayama H, Raaschou HO, Olsen TS. Ipsilateral pushing in stroke: incidence, relation to neuropsychological symptoms, and impact on rehabilitation. The Copenhagen Stroke Study. Arch Phys Med Rehabil 1996; 77 (1) 25-28
  • 15 Gialanella B, Monguzzi V, Santoro R, Rocchi S. Functional recovery after hemiplegia in patients with neglect: the rehabilitative role of anosognosia. Stroke 2005; 36 (12) 2687-2690
  • 16 Na DL, Adair JC, Williamson DJ, Schwartz RL, Haws B, Heilman KM. Dissociation of sensory-attentional from motor-intentional neglect. J Neurol Neurosurg Psychiatry 1998; 64 (3) 331-338
  • 17 Coslett HB. Spatial influences on motor and language function. Neuropsychologia 1999; 37 (6) 695-706
  • 18 Spinazzola L, Cubelli R, Della Sala S. Impairments of trunk movements following left or right hemisphere lesions: dissociation between apraxic errors and postural instability. Brain 2003; 126 (Pt 12) 2656-2666
  • 19 Cicerone KD, Langenbahn DM, Braden C , et al. Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Arch Phys Med Rehabil 2011; 92 (4) 519-530
  • 20 Richards LG, Latham NK, Jette DU, Rosenberg L, Smout RJ, DeJong G. Characterizing occupational therapy practice in stroke rehabilitation. Arch Phys Med Rehabil 2005; 86 (12) (Suppl. 02) S51-S60
  • 21 Salter K, Teasell R, Foley N, Allen L. Chapter 14: Aphasia. Evidence-Based Review of Stroke Rehabilitation. Ontario, Canada. 2013. Available at: http://www.ebrsr.com/evidence-review/14-aphasia . Accessed September 5, 2014
  • 22 Springer L, Huber W, Schlenck KJ, Schlenck C. Agrammatism: Deficit or compensation? Consequences for aphasia therapy. Neuropsychol Rehabil 2000; 10 (3) 279-309
  • 23 Pedersen PM, Jørgensen HS, Nakayama H, Raaschou HO, Olsen TS. Aphasia in acute stroke: incidence, determinants, and recovery. Ann Neurol 1995; 38 (4) 659-666
  • 24 Barrett AM, Galletta EE, Zhang J, Masmela JR, Adler US. Stroke survivors over-estimate their medication self-administration (MSA) ability, predicting memory loss. Brain Inj 2014; 28 (10) 1328-1333
  • 25 Barrett A, Foundas A. Apraxia. Principles and Practice of Behavioral Neurology and Neuropsychology. Philadelphia, PA: Saunders/Churchill Livingstone/Mosby; 2004: 409-422
  • 26 Sunderland A, Shinner C. Ideomotor apraxia and functional ability. Cortex 2007; 43 (3) 359-367
  • 27 Poizner H, Merians AS, Clark MA, Rothi LJG, Heilman KM, Kinematic approaches to the study of apraxic disorders. In: Rothi LJG, Heilman KM. , eds. Apraxia: The Neuropsychology of Action; 1997: 93-109
  • 28 Bobath B. Adult Hemiplegia: Evaluation and Treatment. London, England: Butterworth-Heinemann; 1990
  • 29 Dobkin BH, Dorsch A. New evidence for therapies in stroke rehabilitation. Curr Atheroscler Rep 2013; 15 (6) 331
  • 30 Robey RR. A meta-analysis of clinical outcomes in the treatment of aphasia. J Speech Lang Hear Res 1998; 41 (1) 172-187
  • 31 Pulvermüller F, Neininger B, Elbert T , et al. Constraint-induced therapy of chronic aphasia after stroke. Stroke 2001; 32 (7) 1621-1626
  • 32 Meinzer M, Djundja D, Barthel G, Elbert T, Rockstroh B. Long-term stability of improved language functions in chronic aphasia after constraint-induced aphasia therapy. Stroke 2005; 36 (7) 1462-1466
  • 33 Balardin JB, Miotto EC. A review of constraint-induced therapy applied to aphasia rehabilitation in stroke patients. Dement Neuropsychol 2009; 3 (4) 275-282
  • 34 Fernandez-Duque D, Posner MI. Brain imaging of attentional networks in normal and pathological states. J Clin Exp Neuropsychol 2001; 23 (1) 74-93
  • 35 Berg IJ, Koning-Haanstra M, Deelman BG. Long-term effects of memory rehabilitation: A controlled study. Neuropsychol Rehabil 1991; 1 (2) 97-111
  • 36 Doornhein K, DeHaan E. Cognitive training for memory deficits in stroke patients. Neuropsychol Rehabil 1998; 8 (4) 393-400
  • 37 Melton A, Bourgeois M. Training compensatory memory strategies via the telephone for persons with TBI. Aphasiology 2005; 19 (3–5) 353-364
  • 38 Glisky EL, Schacter DL, Tulving E. Learning and retention of computer-related vocabulary in memory-impaired patients: method of vanishing cues. J Clin Exp Neuropsychol 1986; 8 (3) 292-312
  • 39 Hildebrandt H, Bussmann-Mork B, Schwendemann G. Group therapy for memory impaired patients: a partial remediation is possible. J Neurol 2006; 253 (4) 512-519
  • 40 Clare L, Jones RS. Errorless learning in the rehabilitation of memory impairment: a critical review. Neuropsychol Rev 2008; 18 (1) 1-23
  • 41 Baddeley A, Wilson BA. When implicit learning fails: amnesia and the problem of error elimination. Neuropsychologia 1994; 32 (1) 53-68
  • 42 Dou ZL, Man DW, Ou HN, Zheng JL, Tam SF. Computerized errorless learning-based memory rehabilitation for Chinese patients with brain injury: a preliminary quasi-experimental clinical design study. Brain Inj 2006; 20 (3) 219-225
  • 43 Sohlberg MM, McLaughlin KA, Pavese A, Heidrich A, Posner MI. Evaluation of attention process training and brain injury education in persons with acquired brain injury. J Clin Exp Neuropsychol 2000; 22 (5) 656-676
  • 44 Tiersky LA, Anselmi V, Johnston MV , et al. A trial of neuropsychologic rehabilitation in mild-spectrum traumatic brain injury. Arch Phys Med Rehabil 2005; 86 (8) 1565-1574
  • 45 Foundas AL. Apraxia: Neural mechanisms and functional recovery. In: Barnes MP, David CG, , eds. Handbook of Clinical Neurology. Vol. 110. Amsterdam, The Netherlands: Elsevier; 2013: 335-345
  • 46 van Heugten CM, Dekker J, Deelman BG, van Dijk AJ, Stehmann-Saris JC, Kinebanian A. Outcome of strategy training in stroke patients with apraxia: a phase II study. Clin Rehabil 1998; 12 (4) 294-303
  • 47 Goldenberg G, Hagmann S. Therapy of activities of daily living in patients with apraxia. Neuropsychol Rehabil 1998; 8 (2) 123-142
  • 48 Smania N, Girardi F, Domenicali C, Lora E, Aglioti S. The rehabilitation of limb apraxia: a study in left-brain-damaged patients. Arch Phys Med Rehabil 2000; 81 (4) 379-388
  • 49 Smania N, Aglioti SM, Girardi F , et al. Rehabilitation of limb apraxia improves daily life activities in patients with stroke. Neurology 2006; 67 (11) 2050-2052
  • 50 Nijboer T, van de Port I, Schepers V, Post M, Visser-Meily A. Predicting functional outcome after stroke: the influence of neglect on basic activities in daily living. Front Hum Neurosci 2013; 7: 182
  • 51 Oh-Park M, Hung C, Chen P, Barrett AM. Severity of spatial neglect during acute inpatient rehabilitation predicts community mobility after stroke. PM R 2014; 6 (8) 716-722
  • 52 Barrett AM. Picturing the body in spatial neglect: descending a staircase. Neurology 2013; 81 (15) 1280-1281
  • 53 Barrett AM, Burkholder S. Monocular patching in subjects with right-hemisphere stroke affects perceptual-attentional bias. J Rehabil Res Dev 2006; 43 (3) 337-346
  • 54 Barrett AM, Goedert KM, Basso JC. Prism adaptation for spatial neglect after stroke: translational practice gaps. Nat Rev Neurol 2012; 8 (10) 567-577
  • 55 Tilikete C, Rode G, Rossetti Y, Pichon J, Li L, Boisson D. Prism adaptation to rightward optical deviation improves postural imbalance in left-hemiparetic patients. Curr Biol 2001; 11 (7) 524-528
  • 56 Shepherd RB, Carr JA. New aspects for the physiotherapy of pushing behaviour, D. Broetz D and H.O. Karnath, Neurorehabilitation 20 (2005), 133–138 (response to discussion paper). NeuroRehabilitation 2005; 20 (4) 343-345
  • 57 Tanridag O, Kirshner HS. Aphasia and agraphia in lesions of the posterior internal capsule and putamen. Neurology 1985; 35 (12) 1797-1801
  • 58 Kreisler A, Godefroy O, Delmaire C , et al. The anatomy of aphasia revisited. Neurology 2000; 54 (5) 1117-1123
  • 59 Marien P, Engelborghs S, Pickut BA, De Deyn PP. Aphasia following cerebellar damage: Fact or fallacy?. J Neurolinguist 2000; 13 (2–3) 145-171
  • 60 Cherney LR, Halper AS, Holland AL, Cole R. Computerized script training for aphasia: preliminary results. Am J Speech Lang Pathol 2008; 17 (1) 19-34
  • 61 Foerde K, Shohamy D. The role of the basal ganglia in learning and memory: insight from Parkinson's disease. Neurobiol Learn Mem 2011; 96 (4) 624-636
  • 62 Saint-Cyr JA, Taylor AE, Lang AE. Procedural learning and neostriatal dysfunction in man. Brain 1988; 111 (Pt 4) 941-959
  • 63 Libet B, Gleason CA, Wright EW, Pearl DK. Time of conscious intention to act in relation to onset of cerebral activity (readiness-potential). The unconscious initiation of a freely voluntary act. Brain 1983; 106 (Pt 3) 623-642
  • 64 Keenan JP. Personal communication with AMB. 2014
  • 65 Geschwind N. The apraxias: neural mechanisms of disorders of learned movement. Am Sci 1975; 63 (2) 188-195
  • 66 Johnson-Frey SH, Newman-Norlund R, Grafton ST. A distributed left hemisphere network active during planning of everyday tool use skills. Cereb Cortex 2005; 15 (6) 681-695
  • 67 Króliczak G, Frey SH. A common network in the left cerebral hemisphere represents planning of tool use pantomimes and familiar intransitive gestures at the hand-independent level. Cereb Cortex 2009; 19 (10) 2396-2410
  • 68 Goldenberg G, Hermsdörfer J, Glindemann R, Rorden C, Karnath HO. Pantomime of tool use depends on integrity of left inferior frontal cortex. Cereb Cortex 2007; 17 (12) 2769-2776
  • 69 Vingerhoets G, Acke F, Alderweireldt AS, Nys J, Vandemaele P, Achten E. Cerebral lateralization of praxis in right- and left-handedness: same pattern, different strength. Hum Brain Mapp 2012; 33 (4) 763-777
  • 70 Króliczak G, Piper BJ, Frey SH. Atypical lateralization of language predicts cerebral asymmetries in parietal gesture representations. Neuropsychologia 2011; 49 (7) 1698-1702
  • 71 Lausberg H, Göttert R, Münssinger U, Boegner F, Marx P. Callosal disconnection syndrome in a left-handed patient due to infarction of the total length of the corpus callosum. Neuropsychologia 1999; 37 (3) 253-265
  • 72 Hartmann K, Goldenberg G, Daumüller M, Hermsdörfer J. It takes the whole brain to make a cup of coffee: the neuropsychology of naturalistic actions involving technical devices. Neuropsychologia 2005; 43 (4) 625-637
  • 73 Rumiati RI, Weiss PH, Shallice T , et al. Neural basis of pantomiming the use of visually presented objects. NeuroImage 2004; 21 (4) 1224-1231
  • 74 Gauthier LV, Taub E, Perkins C, Ortmann M, Mark VW, Uswatte G. Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke. Stroke 2008; 39 (5) 1520-1525
  • 75 Page SJ, Szaflarski JP, Eliassen JC, Pan H, Cramer SC. Cortical plasticity following motor skill learning during mental practice in stroke. Neurorehabil Neural Repair 2009; 23 (4) 382-388
  • 76 Hesse S, Werner C, Schonhardt EM, Bardeleben A, Jenrich W, Kirker SG. Combined transcranial direct current stimulation and robot-assisted arm training in subacute stroke patients: a pilot study. Restor Neurol Neurosci 2007; 25 (1) 9-15
  • 77 Kosslyn SM, Koenig O, Barrett A, Cave CB, Tang J, Gabrieli JD. Evidence for two types of spatial representations: hemispheric specialization for categorical and coordinate relations. J Exp Psychol Hum Percept Perform 1989; 15 (4) 723-735
  • 78 Burcham KJ, Corwin JV. Effects of delay and duration of light deprivation on recovery of function from neglect induced by unilateral medial agranular prefrontal cortex lesions in rats. Psychobiology (Austin, Tex) 1998; 26 (3) 216-230
  • 79 Payne BR, Rushmore RJ. Functional circuitry underlying natural and interventional cancellation of visual neglect. Exp Brain Res 2004; 154 (2) 127-153
  • 80 DesJardin JT, Holmes AL, Forcelli PA , et al. Defense-like behaviors evoked by pharmacological disinhibition of the superior colliculus in the primate. J Neurosci 2013; 33 (1) 150-155
  • 81 Sprague JM. Interaction of cortex and superior colliculus in mediation of visually guided behavior in the cat. Science 1966; 153 (3743) 1544-1547