Pulsatility Index in Carotid Arteries is Increased in Levothyroxine-Treated Hashimoto Disease

M. Owecki; N. Sawicka-Gutaj; M. K. Owecki; W. Ambrosius; J. Dorszewska; A. Oczkowska; M. Michalak; J. Fischbach; W. Kozubski; M. Ruchała

doi:10.1055/s-0034-1398491

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2015; 47(08): 577-580
DOI: 10.1055/s-0034-1398491

Endocrine Care

Pulsatility Index in Carotid Arteries is Increased in Levothyroxine-Treated Hashimoto Disease

Authors

M. Owecki^*

¹Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland
N. Sawicka-Gutaj^*

¹Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland
M. K. Owecki

²Department of Neurology, Poznan University of Medical Sciences, Poznań, Poland
W. Ambrosius

²Department of Neurology, Poznan University of Medical Sciences, Poznań, Poland
J. Dorszewska

²Department of Neurology, Poznan University of Medical Sciences, Poznań, Poland
A. Oczkowska

²Department of Neurology, Poznan University of Medical Sciences, Poznań, Poland
M. Michalak

³Department of Informatics and Statistics, Poznan University of Medical Sciences, Poznań, Poland
J. Fischbach

¹Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland
W. Kozubski

²Department of Neurology, Poznan University of Medical Sciences, Poznań, Poland
M. Ruchała

¹Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland

Abstract

The aim of this case-control study was to evaluate carotid hemodynamic variables and traditional cardiovascular risk factors in women with Hashimoto thyroiditis (HT). The study group consisted of 31 females with HT on levothyroxine (L-T4) and 26 euthyroid women with HT without L-T4 matched for age and body mass index (BMI) as controls. Carotid intima-media thickness (CIMT), carotid extra-media thickness (CEMT), and pulsatility indexes in common carotid artery (PI CCA) and in internal carotid artery (PI ICA) were measured. BMI, waist circumference, lipid profile, fasting glucose and insulin levels, and parameters of thyroid function [TSH, free thyroxine (FT4) and antithyroperoxidase antibodies (TPOAbs)] were assessed. The study and the control groups did not differ in age, BMI, waist circumference, lipid profile, fasting glucose, and insulin levels. Results are expressed as median (IQR). Treated HT group had higher FT4 levels than nontreated [17.13 (5.11) pmol/l vs. 14.7 (2.27) pmol/l; p=0.0011] and similar TSH [1.64 (2.08) IU/ml vs. 2.07 (3.14) IU/ml; p=0.5915]. PI CCA and PI ICA were higher in the study group than in controls (p=0.0224 and p=0.0477, respectively). The difference remained statistically significant for PI ICA and PI CCA after adjustment for other variables (coefficient=0.09487; standard error=0.04438; p=0.037 and coefficient=0.1786; standard error=0.0870; p=0.0449, respectively). CIMT and CEMT were similar in both groups (p=0.8746 and p=0.0712, respectively). Women with HT on L-T4 replacement therapy have increased PI in common and internal carotid arteries than nontreated euthyroid HT patients. Therefore, it seems that hypothyroidism, but not autoimmune thyroiditis per se, influences arterial stiffness.

Key words

autoimmune thyroiditis - Hashimoto disease - vascular stiffness - cardiovascular disease

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