ZWR - Das Deutsche Zahnärzteblatt 2015; 124(04): 148-155
DOI: 10.1055/s-0035-1548773
CME-Fortbildung
© Georg Thieme Verlag KG Stuttgart · New York

Der prophylaktische Einsatz von Probiotika

H. StaudteMarktRettenbach
Further Information

Publication History

Publication Date:
23 April 2015 (online)

Lernziele

Nach dem Durcharbeiten dieses Beitrags sollten Sie in der Lage sein,

  • die Hintergründe und Wirkmechanismen von Probiotika zu verstehen,

  • die Möglichkeiten des Einsatzes von Probiotika im Rahmen der Karies- und Parodontitisbehandlung abschätzen zu können,

  • Patienten bzgl. des Potenzials probiotischer Nahrungsmittel in der Karies- und Parodontitisprävention zu beraten.

 
  • Literatur

  • 1 Goeser F. Mikrobiomforschung: Wie körpereigene Keime als „Superorgan“ agieren. Dtsch Ärztebl 2012; 109 A-1317, B-1140, C-1120
  • 2 Blumberg BS. Obituary: Joshua Lederberg (1925–2008). Nature 2008; 452: 422
  • 3 Marsh PD, Percival RS. The oral microflora – friend or foe? Can we decide?. Int Dent J 2006; 56: 233-239
  • 4 Dorożyńska I, Majewska-Szczepanik M, Marcińska K et al. Partial depletion of natural gut flora by antibiotic aggravates collagen induced arthritis (CIA) in mice. Pharmacol Rep 2014; 66: 250-255
  • 5 Newton DF, Macfarlane S, Macfarlane GT. Effects of antibiotics on bacterial species composition and metabolic activities in chemostats containing defined populations of human gut Microorganisms. Antimicrob Agents Chemother 2013; 57: 2016-2025
  • 6 Feldmeier H. Lebenswichtiges Getümmel im Darm. Pharm Z 2012; 47 (online)
  • 7 Porter JR. Antony van Leeuwenhoek: tercentenary of his discovery of bacteria. Bacteriological Rev 1976; 40: 260-269
  • 8 Loesche WJ. Chemotherapy of dental plaque infections. Oral Sci Rev 1976; 9: 65-107
  • 9 Wade WG. Non-culturable bacteria in complex commensal populations. Adv Appl Microbiol 2004; 54: 93-106
  • 10 Park JH, Lee JK, Um HS et al. A periodontitis-associated multispecies model of an oral biofilm. J Periodontol Implant Sci 2014; 44: 79-84
  • 11 Cho T, Nagao JI, Imayoshi R et al. Importance of diversity in the oral microbiota including Candida species revealed by high-throughput technologies. Int J Dent 2014; 2014: 45439
  • 12 Annapurna CS, Prince CN, Sivaraj S et al Oral manifestations of HIV patients in South Indian population. J Pharm Bioallied Sci 2012; 4: 364-368
  • 13 Human Microbiome Project Consortium . Structure, function and diversity of the healthy human microbiome. Nature 2012; 486: 207-214
  • 14 Mager DL, Ximenez-Fyvie LA, Haffajee AD et al. Distribution of selected bacterial species on intraoral surfaces. J Clin Periodontol 2003; 30: 644-654
  • 15 Paster BJ, Boches SK, Galvin JL et al. Bacterial diversity in human subgingival plaque. J Bact 2001; 183: 3770-3783
  • 16 Bik EM, Long CD, Armitage GC et al. Bacterial diversity in the oral cavity of ten healthy individuals. ISME J 2010; 4: 962-974
  • 17 Kapil V, Milsom AB, Okorie M et al. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived no. Hypertension 2010; 56: 274-281
  • 18 Govoni M, Jansson EA, Weitzberg E et al. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide. Biol Chem 2008; 19: 333-337
  • 19 Petersson J, Carlstrom M, Schreiber O et al. Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash. Free Radic Biol Med 2009; 46: 1068-1075
  • 20 Kumar PS. Oral microbiota and systemic disease. Anaerobe 2013; 24: 90-93
  • 21 Wade WG. The oral microbiome in health and disease. Pharmacol Res 2013; 69: 137-143
  • 22 Cagetti MG, Mastroberadino S, Milia E et al. The use of probiotic strains in caries prevention: a systematic review. Nutrients 2013; 5: 2530-2550
  • 23 Lang C, Böttner M, Holz C et al. Specific Lactobacillus/mutans streptococcus co-aggregation. J Dent Res 2010; 89: 175-179
  • 24 Tanzer JM, Thomson A, Lang C et al. Caries inhibition by and safety of Lactobacillus paracasei DSMZ 16671. J Dent Res 2010; 89: 921-926
  • 25 Holz C, Alexander C, Balcke C et al. Lactobacillus paracasei DMSZ 16671 reduces mutans streptococci: a short-term pilot study. Probiotics Antimicrob Proteins 2013; 5: 259-263
  • 26 Teanpaisan R, Piwat S. Lactobacillus paracasei SD1, a novel probiotic, reduces mutans streptococci in human volunteers: a randomized placebo-controlled trail. Clin Oral Investig 2014; 18: 857-862
  • 27 Hasslöf P, West CE, Videhult FK et al. Early intervention with probiotic Lactobacillus paracasei F19 has no long-term effect on caries experience. Caries Res 2013; 47: 559-565
  • 28 Glavina D, Gorseta K, Skrinjaric I et al. Effect of LGG yoghurt on Streptococcus mutans and Lactobacillus spp. salivary counts in children. Coll Antropol 2012; 36: 129-132
  • 29 Jindal G, Pandey RK, Agarwal J et al. A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children. Eur Arch Paediatr Dent 2011; 12: 211-215
  • 30 Stecksén-Blicks C, Sjöström I, Twetman S. Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study. Caries Res 2009; 43: 374-381
  • 31 Romani-Vestman N, Hasslöf P, Keller MK et al. Lactobacillus reuteri influences regrowth of mutans streptococci after full-mouth disinfection: a double-blind, randomized controlled trial. Caries Res 2013; 47: 338-345
  • 32 Cildir SK, Sandalli N, Nazli S. A novel delivery system of probiotic drop and its effect on dental caries risk factors in cleft lip/palate children. Cleft Palate Craniofac J 2012; 49: 369-372
  • 33 Campus G, Cocco F, Carta G et al. Effect of a daily dose of Lactobacillus brevis CD2 lozenges in high caries risk schoolchildren. Clin Oral Investig 2014; 18: 555-561
  • 34 Teughels W, van Esche M, Sliepen I et al. Probiotics and oral healthcare. Periodontol 2000 2008; 48: 111-147
  • 35 Aminabadi NA, Erfanparast L, Ebrahimi A et al. Effect of chlorhexidine pretreatment on the stability of salivary lactobacilli probiotic in six- to twelve-year-old children: A randomized controlled trial. Caries Res 2011; 45: 148-154
  • 36 Bradshaw DJ, Lynch RJ. Diet and the microbial aetiology of dental caries: new paradigms. Int Dent J 2013; 63: 64-72
  • 37 Thurnheer T, Belibasakis GN, Bostanci N. Colonisation of gingival epithelia by subgingival biofilms: Role of “red complex” bacteria. Arch Oral Biol 2014; 59: 977-986
  • 38 Nyvad B, Kilian M. Microbiology of early colonization of human enamel and root surfaces in vivo. Scand J Dent Res 1987; 95: 369-380
  • 39 He X, Hu W, Kaplan CW et al. Adherence to streptococci facilitates Fusobacterium nucleatum integration into an oral microbial community. Microb Ecol 2012; 63: 532-542
  • 40 Nissen L, Sqorbati B, Biavati B et al. Lactobacillus salivarius und L. grasseri down-regulate Aggregatibacter actinomycetemcomitans exotoxins expression. Ann Microbiol 2014; 64: 611-617
  • 41 Maekawa T, Hajishengallis G. Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. J Periodontal Res 2014; 49: 785–791
  • 42 Teughels W, Newman MG, Coucke W et al. Guiding periodontal pocket recolonization: A proof of a concept. J Dent Res 2007; 86: 1078-1082
  • 43 Teughels W, Durukan A, Ozcelik O et al. Clinical and microbiological effect of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 2013; 40: 1025-1035
  • 44 Szkaradkiewicz AK, Stopa J, Karpinski TM. Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis. Arch Immunol Ther Exp 2014; im Druck
  • 45 Vicario M, Santos A, Violant D et al. Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteri Prodentis: a preliminary randomized clinical trial. Acta Odontol Scand 2013; 71: 813-819
  • 46 Iwamoto T, Suzuki N, Tanabe K et al. Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 110: 201-208
  • 47 Shimauchi H, Mayanagi G, Nakaya S et al. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. J Clin Periodontol 2008; 35: 897-905
  • 48 Riccia DN, Bizzini F, Perilli MG et al. Anti-inflammatory effects of Lactobacillus brevis CD2 on periodontal disease. Oral Dis 2007; 13: 376-385
  • 49 Gupta G. Probiotics and periodontal health. J Med Life 2011; 4: 387-394
  • 50 Boyle RJ, Robins-Browne MR, Tang M. Probiotic use in clinical practice: What are the risks?. Am J Clin Nutr 2006; 83: 1256-1264