Four New Amaryllidaceae Alkaloids from Lycoris radiata and Their Cytotoxicity

Abstract

Four new Amaryllidaceae alkaloids, named lycoranines C–F (1–4), together with seven known ones (5–11) were isolated from the bulbs of Lycoris radiata. Their structures with absolute configurations were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, circular dichroism spectra, modified Mosherʼs method, and molecular modeling calculation. Compounds 6, 7, 10, and 11 exhibited a potent inhibitory effect on A549 and LoVo cells with IC₅₀ values ranging from 3.97 ± 0.36 to 17.37 ± 1.57 µM.

Key words

Lycoris radiata - Amaryllidaceae - Amaryllidaceae alkaloid - cytotoxic activity

^* These authors contributed equally to this work.

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