Four New Amaryllidaceae Alkaloids from Lycoris radiata and Their Cytotoxicity

Song Ang; Xia-Mei Liu; Xiao-Jun Huang; Dong-Mei Zhang; Wei Zhang; Lei Wang; Wen-Cai Ye

doi:10.1055/s-0035-1557743

Planta Medica, Table of Contents

Planta Med 2015; 81(18): 1712-1718
DOI: 10.1055/s-0035-1557743

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Four New Amaryllidaceae Alkaloids from Lycoris radiata and Their Cytotoxicity

Song Ang^*

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China

,

Xia-Mei Liu^*

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China

,

Xiao-Jun Huang

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China

,

Dong-Mei Zhang

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

,

Wei Zhang

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

,

Lei Wang

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China

,

Wen-Cai Ye

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China

› Author Affiliations

Abstract

Four new Amaryllidaceae alkaloids, named lycoranines C–F (1–4), together with seven known ones (5–11) were isolated from the bulbs of Lycoris radiata. Their structures with absolute configurations were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, circular dichroism spectra, modified Mosherʼs method, and molecular modeling calculation. Compounds 6, 7, 10, and 11 exhibited a potent inhibitory effect on A549 and LoVo cells with IC₅₀ values ranging from 3.97 ± 0.36 to 17.37 ± 1.57 µM.

Key words

Lycoris radiata - Amaryllidaceae - Amaryllidaceae alkaloid - cytotoxic activity

Full Text

References

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