Abstract
A strong relationship exists between acute coronary syndrome (ACS) and platelets (PLTs)
volume. Mean platelet volume (MPV) is a parameter of PLT functions and a marker for
increased PLT activation. The aim of this study was to determine early changes in
number of total PLT and MPV in different manifestation of ACS and to find out predictive
value of MPV in the spectrum of ACS. This was a prospective study. One hundred thirty-four
ACS patients were enrolled, 76 of them finished the study. PLT and MPV in patients
with unstable angina, non-ST elevation, and ST elevation myocardial infarctions were
determined on arrival and 1, 3, 72 hours, and 7 days after the admission to hospital.
There was decrease in PLT and MPV in all three groups after 3 hours of arrival in
hospital in comparison with admission values. In the later time period (72 hours and
7 days), there was an increase in PLT and MPV only in patients with acute myocardial
infarction (AMI). We have revealed completely new dynamics in early changes in MPV
and PLT count in patients with AMI. Biphasic changes were found in early phase after
admission to the hospital. Fast response in these parameters raises new questions
about their origin.
Keywords
mean platelet volume - platelet count - large platelets - platelet activation - platelet
function - acute coronary syndrome - early changes
