The Contribution of Plasma (R)- & (S)-warfarin and Vitamin K Concentrations to Intra-individual Variability in Anticoagulation

• References

• 1 Sudlow M, Thompson R, Thwaites B, Rogers H, Kenny RA. Prevalence of atrial fibrillation and eligibility for anticoagulants in the community. Lancet 1998; 352: 1167-71.
• 2 Landefeld CS, Goldman L. Major bleeding in outpatients treated with warfarin; incidence and prediction by factors known at the start of outpatient therapy. Am J Med 1989; 87: 144-52.
• 3 Naidong W, Lee JW. Development and validation of a high performance liquid chromatographic method for the quantitation of warfarin enantiomers in human plasma. J Pharm Biomed Anal 1993; 11: 785-92.
• 4 Davidson KW, Sadowski JA. Determination of vitamin K compounds in plasma or serum by high performance liquid chromatography using post column chemical reduction and fluorimetric detection methods. Enzymology 1997; 282: 408-21.
• 5 Kalra PA, Cooklin M, Wood G, O’Shea GM, Homes AM. Dietary modification as a cause of anticoagulation instability. Lancet 1988; ii: 803.