Lack of Association between Hemochromatosis and Factor V Leiden Mutations in the Czech Population

Thromb Haemost 1999; 82(03): 1197-1198
DOI: 10.1055/s-0037-1614353

Letters to the Editor

Schattauer GmbH

Authors

Ingrid Hrachovinova

¹From the ¹Institute of Haematology and Blood Transfusion, and Faculty Hospital, 1. Medical Faculty UK, Prague, Czech Republic
Blanka Rypackova

²Department of Haematology, Faculty Hospital, 1. Medical Faculty UK, Prague, Czech Republic
Daniel Vyoral

¹From the ¹Institute of Haematology and Blood Transfusion, and Faculty Hospital, 1. Medical Faculty UK, Prague, Czech Republic

References
1 Xie YD, Lillicrap DP, Taylor SAM. An association between the common hereditary hemochromatosis mutation and the factor V Leiden allele in a population with thrombosis. Blood 1998; 92: 1461-2.
2 Andrews NC, Levy JE. Iron is hot: An update on the pathophysiology of hemochromatosis. Blood 1998; 92: 1845-51.
3 Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
4 Lynas C. A cheaper and more rapid polymerase chain reaction-restriction fragment length polymorphism method for the detection of the HLA-H gene mutation occurring in hereditary hemochromatosis. Blood 1997; 90: 4235-6.
5 Tordai A, Andrikovics H, Kalmár L, Rajczy K, Pénzes M, Sarkadi B, Klein I, Váradi A. High frequency of the haemochromatosis C282Y mutation in Hungary could argue against a Celtic origin of the mutation. J Med Genet 1998; 35: 878-9.
6 Nielsen P, Carpinteiro S, Fischer R, Cabeda JM, Porto G, Gabbe EE. Prevalence of the C282Y and H63D mutations in the HFE gene in patients with hereditary haemochromatosis and in control subjects from Northern Germany. Br J Haematol 1998; 103: 842-5.