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Thromb Haemost 1999; 82(04): 1376-1377
DOI: 10.1055/s-0037-1614404
DOI: 10.1055/s-0037-1614404
Letters to the Editor
A Possible Solution to the Paradox of the “Lupus Anticoagulant”: Antiphospholipid Antibodies Accelerate Thrombin Generation by Inhibiting Annexin-V
These studies were supported in part by a grant from the New York Community Trust and a Newman Research Followship.
Further Information
Publication History
Received
05 April 1999
Accepted after resubmission
18 June 1999
Publication Date:
08 December 2017 (online)
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References
- 1 Hughes GR. Hughes’ syndrome: the antiphospholipid syndrome. A historical view. Lupus 1998; 7 (Suppl. 02) S1-S4.
- 2 Rand JH. The antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms. Am J Med Sci 1998; 316: 142-51.
- 3 Rand JH, Wu XX, Andree HAM, Lockwood CJ, Guller S, Scher J, Harpel PC. Pregnancy loss in the antiphospholipid-antibody syndrome – a possible thrombogenic mechanism. N Engl J Med 1997; 337: 154-60.
- 4 Rand JH, Wu XX, Andree HAM, Alexander Ross JB, Rosinova E, Gascon-Lema MG, Calandri C, Harpel PC. Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a »lupus procoagulant« phenomenon. Blood 1998; 92: 1652-60.
- 5 Andree HAM, Stuart MC, Hermens WT, Reutelingsperger CP, Hemker HC, Frederik PM, Willems GM. Clustering of lipid-bound annexin V may explain its anticoagulant effect. J Biol Chem 1992; 267: 17907-12.