The Effects of Angiotensin Metabolites on the Regulation of Coagulation and Fibrinolysis in Cultured Rat Aortic Endothelial Cells

Hiromi Nishimura; Hajime Tsuji; Haruchika Masuda; Teruhisa Kasahara; Masami Yoshizumi; Tatsuya Sugano; Shinzo Kimura; Hidehiko Kawano; Yasufumi Kunieda; Shingo Yano; Katsumi Nakagawa; Hidetsugu Kitamura; Yoshifumi Nakahara; Shohei Sawada; Masao Nakagawa

doi:10.1055/s-0037-1614864

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(05): 1516-1521
DOI: 10.1055/s-0037-1614864

Rapid Communications

Schattauer GmbH

The Effects of Angiotensin Metabolites on the Regulation of Coagulation and Fibrinolysis in Cultured Rat Aortic Endothelial Cells

Authors

Hiromi Nishimura

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Hajime Tsuji

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Haruchika Masuda

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Teruhisa Kasahara

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Masami Yoshizumi

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Tatsuya Sugano

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Shinzo Kimura

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Hidehiko Kawano

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Yasufumi Kunieda

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Shingo Yano

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Katsumi Nakagawa

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Hidetsugu Kitamura

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Yoshifumi Nakahara

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Shohei Sawada

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Masao Nakagawa

¹From the Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

Abstract

Summary

Not only angiotensin II (Ang II) but also other angiotensin metabolites such as angiotensin I (Ang I), angiotensin III (Ang III), angiotensin IV, or angiotensin 1-7 have recently been reported to have various activities. Few data, however, are available on the regulation of thrombus formation. In this study, we investigated the effects of angiotensin metabolites on the mRNA expression of tissue factor (TF), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor-1 (PAI-1), and tissue type plasminogen activator (TPA) in cultured rat aortic endothelial cells. None of the used angiotensin metabolites altered TFPI or TPA mRNA expression levels. Ang I, Ang II, and Ang III made TF and PAI-1 mRNA inductions which were inhibited by an selective antagonist of angiotensin II type 1 receptors. These metabolites made TF predominant to TFPI or PAI-1 to TPA, and could render endothelial cells thrombogenic.

Key words

Angiotensin - thrombosis - fibrinolysis - tissue factor - plasminogen activator inhibitor 1

Full Text

References

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