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Thromb Haemost 1998; 79(03): 520-522
DOI: 10.1055/s-0037-1614937
Review Articles
Schattauer GmbH

Platelet cNOS Activity Is Reduced in Patients with IDDM and NIDDM

Valentino Martina
1   Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy
,
Guido A. Bruno
1   Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy
,
Fulvia Trucco
1   Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy
,
Elena Zumpano
1   Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy
,
Milena Tagliabue
1   Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy
,
Cataldo Di Bisceglie
1   Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy
,
Gianpiero Pescarmona
1   Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy
› Author Affiliations
Further Information

Publication History

Received 03 March 1997

Accepted after resubmission 05 November 1997

Publication Date:
07 December 2017 (online)

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Summary

Several studies in vitro and in vivo suggest that the nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to vascular alteration facilitating platelet-vascular wall interaction, adhesion of monocytes to endothelium, vascular smooth muscle proliferation and by decreasing endothelium-dependent vasodilation. In this study we evaluated the activity of the constitutive nitric oxide synthase (cNOS) in platelets of patients with insulin-dependent diabetes mellitus (IDDM) and with non-insulin-dependent diabetes mellitus (NIDDM). When compared to that of normal subjects, cNOS activity is significantly lower in patients with IDDM and with NIDDM (1.57 ± 0.25 vs. 0.66 ± 0.10 fmol/min/10 9 PLTs and 1.57 ± 0.25 vs. 0.67 ± 0.08, respectively; p <0.005). These data demonstrate that the platelet cNOS activity is decreased in diabetes mellitus.

 

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