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Thromb Haemost 1998; 79(04): 837-842
DOI: 10.1055/s-0037-1615074
Rapid Communication
Schattauer GmbH

Relations of Platelet Ca2+ Handling and Membrane Microviscosity to Vascular Tone and Restenosis after Angioplasty in Human Coronary Artery

Claude Le Feuvre
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
Kim-Hanh Le Quan Sang
2   From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France
,
Annie Brunet
2   From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France
,
Didier Catuli
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
Jean-Philippe Metzger
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
André Vacheron
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
Marie-Aude Devynck
2   From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France
› Author Affiliations
Further Information

Publication History

Received 07 March 1997

Accepted after resubmission 24 November 1997

Publication Date:
07 December 2017 (online)

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Summary

This study was designed to assess whether platelet Ca2+ handling or membrane microviscosity could be considered as indexes of vascular tone, or could help to predict an increased risk of restenosis after coronary angioplasty. Vascular tone was quantified in 21 patients with stable angina by the vasodilator response to sin-1 intracoronary injection in the reference coronary segment and by the importance of the acute recoil after angioplasty in the narrowed segment. The degree of restenosis was quantified by coronary angiography 6 months later.

Individual values of relative sin-1-induced changes in the reference coronary diameter were positively correlated with cytosolic Ca2+ concentration in unstimulated platelets, irrespective of the extracellular Ca2+ concentration (p <0.01). This relationship was also observed with the thrombin-evoked Ca2+ changes, measured in the absence of a Ca2+ influx (p = 0.01). No relationship was found between sin-1-induced coronary changes and membrane microviscosity evaluated by TMADPH and DPH anisotropies or platelet volume, or between degree of acute recoil and platelet characteristics.

In conclusion, platelet Ca2+ reflects the vasodilating efficacy in response to sin-1, but cannot help to predict restenosis after coronary angioplasty.

 

  • References

  • 1 Luscher TF, Dubey RK. Endothelium and platelet-derived vasoactive substances: role in the regulation of vascular tone and growth. Hypertension: Pathophysiology, Diagnosis and Management. 2nd edition. Laragh JH, Brenner BM. (eds) Raven Press, Ltd; New York: 1995: 609-30.
    Google Scholar
  • 2 The ESPRIM trial: short-term treatment of acute myocardial infarction with molsidomine. Lancet 1994; 344: 91-7.
    PubMedGoogle Scholar
  • 3 Califf RM, Fortin DF, Frid DJ, Harlan WR, Ohman EM, Bengston JR, Nelson CL, Tcheng JE, Mark DB, Stack RS. Restenosis after coronary angioplasty: an overview. J Am Coll Cardiol 1991; 17: 2B-13B.
    PubMedGoogle Scholar
  • 4 Smyth DW, Martin JF, Michalis L, Bucknall CA, Jewitt DE. Influence of platelet size before coronary angioplasty on subsequent restenosis. Eur J Clin Invest 1993; 23: 361-7.
    CrossrefPubMedGoogle Scholar
  • 5 Topol EJ, Califf RM, Weisman HF, Ellis SG, Tcheng JE, Worley S, Ivanhoe R, George BS, Fintel D, Weston M, Sigmon K, Anderson KM, Lee KL, Willerson JT. on behalf of the EPIC investigators. Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at 6 months. Lancet 1994; 343: 881-6.
    CrossrefPubMedGoogle Scholar
  • 6 Harker LA. Role of platelets and thrombosis in mechanisms of acute occlusion and restenosis after angioplasty. Am J Cardiol 1987; 60: 21B-8B.
    PubMedGoogle Scholar
  • 7 Bauters C, Lablanche JM, Renaud N, McFadden EP, Hamon M, Bertrand ME. Morphological changes after percutaneous transluminal coronary angioplasty of unstable plaques. Insights from serial angioscopic follow-up. Eur Heart J 1996; 17: 1554-9.
    CrossrefPubMedGoogle Scholar
  • 8 Lam JYT, Latour JG, Lesperance J, Waters D. Platelet aggregation, coronary artery disease progression and future coronary events. Am J Cardiol 1994; 73: 333-8.
    CrossrefPubMedGoogle Scholar
  • 9 Tschoepe D, Schultheib HP, Kolarov P, Schwippert B, Dannehl K, Nieuwenhuis HK, Kehrel B, Strauer B, Gries FA. Platelet membrane activation markers are predictive for increased risk of acute ischemic events after PTCA. Circulation 1993; 88: 37-42.
    CrossrefPubMedGoogle Scholar
  • 10 Nurden AT, Macchi L, Bihour C, Durrieu C, Besse P, Nurden P. Markers of platelets activation in coronary heart disease patients. Eur J Clin Invest. 1994 24: Suppl 1, 42-5.
    PubMedGoogle Scholar
  • 11 Montalescot G, Ankri A, Vicaut E, Drobinski Y, Thomas D. Fibrinogen after coronary angioplasty as a risk factor for restenosis. Circulation 1995; 92: 31-8.
    PubMedGoogle Scholar
  • 12 Erne P, Bolli P, Burgisser E, Bühler FR. Correlation of platelet calcium with blood pressure. Effect of antihypertensive therapy. N Engl J Med 1984; 31: 1084-8.
    PubMedGoogle Scholar
  • 13 Le Quan Sang KH, Devynck MA. Increased platelet cytosolic free calcium in essential hypertension. J Hypertens 1986; 4: 564-74.
    PubMedGoogle Scholar
  • 14 Ueno H, Mikawa M, Takata M, Asanoi H, Ida H, Sasayama S, Kagamimori S. Does cytosolic free calcium concentration in platelets reflect tone and structural changes of resistance vessels. J Hypertens 1988; 6 (Suppl. 04) S255-7.
    CrossrefPubMedGoogle Scholar
  • 15 Bolli P, Erne P, Hulthen UL, Ritz R, Kiowski W, Hua Ji B, Bühler FR. Parallel reduction of calcium influx dependent vasoconstriction and platelet free calcium concentration with calcium entry and β-adrenoceptor blockade. J Cardiovasc Pharmacol 1984; 6: S996-1001.
    CrossrefPubMedGoogle Scholar
  • 16 Le Feuvre C, Bonan R, Côté G, Crépeau J, de Guise P, Lespérance J, Théroux P. Five-to ten-year outcome after multivessel percutaneous transluminal coronary angioplasty. Am J Cardiol 1993; 71: 1153-8.
    CrossrefPubMedGoogle Scholar
  • 17 Astarie-Dequeker C, Iouzalen L, David-Dufilho M, Devynck MA. In vitro inhibition by endothelins of thrombin-induced aggregation and Ca2+ mobilization in human platelets. Br J Pharmacol 1992; 106: 966-71.
    CrossrefPubMedGoogle Scholar
  • 18 Le Quan Sang KH, Lantoine F, Devynck MA. Influence of authentic nitric oxide on basal cytosolic [Ca2+] and Ca2+ release from internal stores. Br J Pharmacol 1996; 119: 1361-6.
    CrossrefPubMedGoogle Scholar
  • 19 Le Quan Sang KH, Mazeaud M, Astarie C, Duranthon V, Driss F, Devynck MA. Plasma lipids and platelet membrane fluidity in essential hypertension. Thromb Haemost 1993; 69: 70-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 20 Hogg N, Darley-Usmar VM, Wilson MT, Moncada S. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J 1992; 281: 419-24.
    CrossrefPubMedGoogle Scholar
  • 21 Johansson JS, Haynes DH. Cyclic GMP increases the rate of the calcium extrusion pump in intact human platelets but has no direct effect on the dense tubular calcium accumulation system. Biochim Biophys Acta 1992; 1105: 40-50.
    CrossrefPubMedGoogle Scholar
  • 22 Le Quan Sang KH, Levenson J, Megnien JL, Simon A, Devynck MA. Platelet cytosolic Ca2+ and membrane dynamics in patients with primary hypercholesterolaemia. Effects of pravastatin. Arterioscler Thromb Vasc Biol 1995; 15: 759-64.
    CrossrefPubMedGoogle Scholar
  • 23 Megnien JL, Sene V, Jeannin S, Hernigou A, Plainfosse MC, Merli I, Atger V, Moatti N, Levenson J, Simon A. and the PCV METRA Group. Coronary calcification and its relation to extracoronary atherosclerosis in asymptomatic hypercholemic men. Circulation 1992; 85: 1799-807.
    CrossrefPubMedGoogle Scholar
  • 24 Kuhn M, Förtermann U. Endothelium-dependent vasodilatation in human epicardial arteries: effect of prolonged exposure to glyceryl trinitrate or sin-1. J Cardiovasc Pharmacol 1989; 14: S54-7.
    PubMedGoogle Scholar
  • 25 Tsao PS, McEvoy LM, Drexler H, Butcher EC, Cooke JP. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation 1994; 89: 2176-82.
    CrossrefPubMedGoogle Scholar
  • 26 Creager MA, Cooke JP, Mendelson ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990; 86: 228-34.
    CrossrefPubMedGoogle Scholar
  • 27 Heistad DD, Armstrong MD, Marcus MI, Piegors DJ, Mark AL. Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. Circ Res 1984; 54: 711-8.
    CrossrefPubMedGoogle Scholar
  • 28 Fuster V, Falk E, Fallon JT, Badimon L, Chesebro JH, Badimon JJ. The three processes leading to post PTCA restenosis: dependence on the lesion substrate. Thromb Haemost 1995; 74: 552-64.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 29 Rensing BJ, Hermans WR, Strauss BH, Serruys PW. Regional differences in elastic recoil after percutaneous transluminal coronary angioplasty: a quantitative angiographic study. J Am Coll Cardiol 1991; 17: 34B-8B.
    PubMedGoogle Scholar
  • 30 Rozenman Y, Gilon D, Welber S, Sapoznikov D, Gotsman MS. Clinical and angiographic predictors of immediate recoil after successful coronary angioplasty and relation to late restenosis. Am J Cardiol 1993; 72: 1020-25.
    CrossrefPubMedGoogle Scholar
  • 31 Steele PM, Chesebro JH, Stantson AW, Holmes Jr DR, Dewanjee MK, Badimon L, Fuster V. Balloon angioplasty: natural history of the pathophysiologic response to injury in a pig model. Circ Res 1985; 57: 105-12.
    CrossrefPubMedGoogle Scholar
  • 32 Banai S, Shou M, Correa R, Jaklitsch MT, Douek PC, Bonner RF, Epstein SE, Unger EF. Rabbit ear model of injury-induced arterial smooth muscle cell proliferation: kinetics, reproductibility, and implications. Circ Res 1991; 69: 748-56.
    CrossrefPubMedGoogle Scholar
  • 33 Badimon L, Badimon JJ, Turitto VT, Vallabhajosula S, Fuster V. Platelet thrombus formation on collagen type I: a model of deep vessel injury: influence of blood rheology, von Willebrand factor, and blood coagulation. Circulation 1988; 78: 1431-42.
    CrossrefPubMedGoogle Scholar
  • 34 Ip JH, Fuster V, Badimon L, Badimon JJ, Taubman MB, Chesebro JH. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol 1990; 15: 1667-87.
    CrossrefPubMedGoogle Scholar
  • 35 Fingerle J, Johnson R, Clowes AW, Majeski MW, Reidy MA. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery. Proc Natl Acad Sci 1989; 86: 8412-6.
    CrossrefPubMedGoogle Scholar
  • 36 Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarizing of canine coronary smooth muscle. Br J Pharmacol 1988; 93: 515-24.
    CrossrefPubMedGoogle Scholar
  • 37 Mintz GS, Popma JJ, Pichard AD, Kent KM, Satler LF, Wong SC, Hong MK. Arterial remodeling after coronary angioplasty. A serial intravascular ultrasound study. Circulation 1996; 94: 35-43.
    CrossrefPubMedGoogle Scholar
  • 38 Shi Y, Pieniek M, Fard A, O’Brien J, Mannion JD, Zalewski A. Adventitial remodeling after coronary arterial injury. Circulation 1996; 93: 340-8.
    CrossrefPubMedGoogle Scholar
  • 39 Franklin SM, Faxon DP. Pharmacologic prevention of restenosis after coronary angioplasty: review of randomized trials. Coron Artery Dis 1993; 4: 232-42.
    CrossrefPubMedGoogle Scholar