Relations of Platelet Ca2+ Handling and Membrane Microviscosity to Vascular Tone and Restenosis after Angioplasty in Human Coronary Artery

Claude Le Feuvre; Kim-Hanh Le Quan Sang; Annie Brunet; Didier Catuli; Jean-Philippe Metzger; André Vacheron; Marie-Aude Devynck

doi:10.1055/s-0037-1615074

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 79(04): 837-842
DOI: 10.1055/s-0037-1615074

Rapid Communication

Schattauer GmbH

Relations of Platelet Ca²⁺ Handling and Membrane Microviscosity to Vascular Tone and Restenosis after Angioplasty in Human Coronary Artery

Claude Le Feuvre

¹From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France

,

Kim-Hanh Le Quan Sang

²From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France

,

Annie Brunet

²From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France

,

Didier Catuli

¹From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France

,

Jean-Philippe Metzger

¹From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France

,

André Vacheron

¹From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France

,

Marie-Aude Devynck

²From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France

› Author Affiliations

Abstract

Summary

This study was designed to assess whether platelet Ca²⁺ handling or membrane microviscosity could be considered as indexes of vascular tone, or could help to predict an increased risk of restenosis after coronary angioplasty. Vascular tone was quantified in 21 patients with stable angina by the vasodilator response to sin-1 intracoronary injection in the reference coronary segment and by the importance of the acute recoil after angioplasty in the narrowed segment. The degree of restenosis was quantified by coronary angiography 6 months later.

Individual values of relative sin-1-induced changes in the reference coronary diameter were positively correlated with cytosolic Ca²⁺ concentration in unstimulated platelets, irrespective of the extracellular Ca²⁺ concentration (p <0.01). This relationship was also observed with the thrombin-evoked Ca²⁺ changes, measured in the absence of a Ca²⁺ influx (p = 0.01). No relationship was found between sin-1-induced coronary changes and membrane microviscosity evaluated by TMADPH and DPH anisotropies or platelet volume, or between degree of acute recoil and platelet characteristics.

In conclusion, platelet Ca²⁺ reflects the vasodilating efficacy in response to sin-1, but cannot help to predict restenosis after coronary angioplasty.

Full Text

References

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