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Thromb Haemost 1998; 79(05): 928-931
DOI: 10.1055/s-0037-1615096
DOI: 10.1055/s-0037-1615096
Review Article
Failure of Thrombolytic Therapy in Patients with Myocardial Infarction Is Associated with High Plasma Levels of Factor VII Antigen
Further Information
Publication History
Received
20 June 1997
Accepted after resubmission
16 January 1998
Publication Date:
07 December 2017 (online)
Summary
Thrombolytic therapy in acute myocardial infarction fails to re-establish coronary blood flow in a significant number of patients. One reason for this may be haemostatic imbalance. We investigated whether coagulation factor VII antigen (FVIIag), fibrinogen and protein C were related to reperfusion. Plasma from 45 patients was drawn before treatment and reperfusion assessed by means of continuous, on-line, vector-ECG analysis.
Amongthe 17 patients with no reperfusion, FVIIag levels were significantly higher than among the 28 with signs of reperfusion (560 vs. 410 μg/l median, p = 0.006). Protein C levels where higher in the group with successful reperfusion (1.10 vs. 1.01 U/ml median, p = 0.03), whereas no difference was seen in fibrinogen levels. The findings were not influenced by plasma-triglycerides, body-mass index, age or time between onset of chest pain and thrombolytic therapy.
The results suggest that FVII is of importance for the formation as well as resolution of coronary clots.
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