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Thromb Haemost 1998; 80(01): 109-113
DOI: 10.1055/s-0037-1615148
Rapid Communication
Schattauer GmbH

Population Pharmacokinetics of Recombinant Factor VIIa in Volunteers Anticoagulated with Acenocoumarol

Pascal Girard
1   Clinical Pharmacology Unit, EA 643 University Claude Bernard, Hôpital Cardiologique, Lyon, France
,
Patrice Nony
1   Clinical Pharmacology Unit, EA 643 University Claude Bernard, Hôpital Cardiologique, Lyon, France
,
Elisabeth Erhardtsen
2   NOVO Nordisk, Gentofte, Denmark
,
Sylvie Delair
1   Clinical Pharmacology Unit, EA 643 University Claude Bernard, Hôpital Cardiologique, Lyon, France
,
Patrick Ffrench
3   Laboratoire d’Hématologie et d’Hémostase, Hôpital Cardiologique, Lyon, France
,
Marc Dechavanne
3   Laboratoire d’Hématologie et d’Hémostase, Hôpital Cardiologique, Lyon, France
,
Jean-Pierre Boissel
1   Clinical Pharmacology Unit, EA 643 University Claude Bernard, Hôpital Cardiologique, Lyon, France
› Author Affiliations
Further Information

Publication History

Received 07 May 1997

Accepted after resubmission 18 February 1998

Publication Date:
08 December 2017 (online)

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Summary

This study establishes a population PK model for FVII clotting activity (FVII:C) after injection of recombinant activated factor VII (rFVIIa) to healthy volunteers. Twenty eight volunteers, anticoagulated with acenocoumarol, received one or two rFVIIa injections, with dose ranging from 5 to 320 μg/kg. The FVII:C kinetic was fitted to a 2 compartment model, with continuous “endogenous perfusion” mimicking endogenous activity. Estimated clearance was 2.4 l/h (20% inter-individual variability and 9% inter-period variability). The volume of distribution at steady-state appeared to be significantly dose dependent: 78 ml/kg for doses ≤20 μg/kg and 88 ml/kg for doses >20 μg/kg respectively, with 16% inter-individual variability. The dose producing 50% of the maximum drop of INR was estimated to be 2.2 μg/kg. The model will be used to better define the dosage regimen for future clinical developments.

 

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