Download PDF
Thromb Haemost 1998; 80(03): 522-523
DOI: 10.1055/s-0037-1615242
Letters to the Editor
Schattauer GmbH

Prevalence of FVR506Q and Prothrombin 20210A Mutations in the Navarrese Population

N. Zabalegui
1   From the Laboratory of Vascular Biology and Thrombosis, Haematology Service, School of Medicine, University of Navarra, Pamplona
,
R. Montes
1   From the Laboratory of Vascular Biology and Thrombosis, Haematology Service, School of Medicine, University of Navarra, Pamplona
,
J. Orbe
1   From the Laboratory of Vascular Biology and Thrombosis, Haematology Service, School of Medicine, University of Navarra, Pamplona
,
M. L. Ayape
2   From the Blood Bank of Navarra, Pamplona, Spain
,
A. Medarde
2   From the Blood Bank of Navarra, Pamplona, Spain
,
J. A. Páramo
1   From the Laboratory of Vascular Biology and Thrombosis, Haematology Service, School of Medicine, University of Navarra, Pamplona
,
E. Rocha
1   From the Laboratory of Vascular Biology and Thrombosis, Haematology Service, School of Medicine, University of Navarra, Pamplona
› Author AffiliationsThis study was supported by a grant from the Gobierno de Navarra.
Further Information

Publication History

Received 14 April 1998

Accepted 13 May 1998

Publication Date:
08 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Dahlbäck B. Resistance to activated protein C caused by the factor V R506Q mutation is a common risk factor for venous thrombosis. Thromb Haemost 1998; 78: 483-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
    PubMedGoogle Scholar
  • 3 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
    CrossrefPubMedGoogle Scholar
  • 4 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
    CrossrefPubMedGoogle Scholar
  • 5 Rees DC. The population genetics of factor V Leiden. Br J Haematol 1996; 95: 579-86.
    CrossrefPubMedGoogle Scholar
  • 6 Lucotte G, Mercier G. Frequency of factor V Leiden (Arg506Gln) in France. Br J Haematol 1998; 99: 241 (letter).
    PubMedGoogle Scholar
  • 7 Hillarp A, Zöller B, Svensson PJ, Dahlbäck B. The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis. Thromb Haemost 1998; 78: 990-2.
    PubMedGoogle Scholar
  • 8 Arruda VR, Annichino-Bizzacchi JM, Gonçalves MS, Costa FF. Prevalence of the prothrombin gene variant (nt20210A) in venous thrombosis and arterial disease. Thromb Haemost 1998; 78: 1430-3.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Cumming AM, Keeney S, Salden A, Bhavnani M, Shwe KH, Hay CRM. The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic population. Br J Haematol 1998; 98: 353-5.
    PubMedGoogle Scholar
  • 10 Corral J, González-Conejero R, Lozano ML, Rivera J, Heras I, Vicente V. The venous thrombosis risk factor 20210 A allele of the prothrombin gene is not a major risk factor for arterial thrombotic disease. Br J Haematol 1998; 99: 304-7.
    PubMedGoogle Scholar
  • 11 Martinelli I, Franchi F, Akwan S, Bettini P, Merati G, Manucci PM. The transition G to A at position 20210 in the 3’-untranslated region of the prothrombin gene is not associated with cerebral ischemia. Blood 1998; 90: 3806 (letter).
    PubMedGoogle Scholar
  • 12 Makris M, Preston FE, Beauchamp NJ, Cooper PC, Daly ME, Hampton KK, Bayliss P, Peake IR, Miller GJ. Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia. Thromb Haemost 1998; 78: 1426-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Alhenc-Gelas M, Le Cam Duchez V, Emmerich J, Frebourg T, Fiessinger JN, Borg JY, Aiach M. The A20210 allele of the prothrombin gene is not frequently associated with the factor V Arg 506 to Gln mutation in thrombophilic families. Blood 1998; 90: 1711 (letter).
    PubMedGoogle Scholar