Plasminogen Activator Inhibitor-1 4G/4G-Genotype Is Associated with Cerebral Sinus Thrombosis in Factor V Leiden Carriers

Ralf Junker; Darius G Nabavi; Endrik Wolff; Peter Lüdemann; Ulrike Nowak-Göttl; Margit Käse; Ruth Bäumer; E. Bernd Ringelstein; Gerd Assmann

doi:10.1055/s-0037-1615449

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 80(04): 706-707
DOI: 10.1055/s-0037-1615449

Letters to the Editor

Schattauer GmbH

Plasminogen Activator Inhibitor-1 4G/4G-Genotype Is Associated with Cerebral Sinus Thrombosis in Factor V Leiden Carriers

Ralf Junker

¹From the Institut für Klinische Chemie und Laboratoriumsmedizin

,

Darius G Nabavi

²Klinik und Poliklinik für Neurologie

,

Endrik Wolff

²Klinik und Poliklinik für Neurologie

,

Peter Lüdemann

²Klinik und Poliklinik für Neurologie

,

Ulrike Nowak-Göttl

³Klinik und Poliklinik für Pädiatrie

,

Margit Käse

⁴Institut für Arterioskleroseforschung, Westfälische WilhelmsUniversität, Münster, Germany

,

Ruth Bäumer

⁴Institut für Arterioskleroseforschung, Westfälische WilhelmsUniversität, Münster, Germany

,

E. Bernd Ringelstein

²Klinik und Poliklinik für Neurologie

,

Gerd Assmann

¹From the Institut für Klinische Chemie und Laboratoriumsmedizin

⁴Institut für Arterioskleroseforschung, Westfälische WilhelmsUniversität, Münster, Germany

› Author Affiliations

Abstract

Full Text

References

References
1 Bousser MG, Chiras J, Bories J, Castaigne P. Cerebral venous thrombosis – a review of 38 cases. Stroke 1985; 16: 199-213.
2 Daif A, Awada A, al Rajeh S, Abduljabbar M, al-Tahan AR, Obeid T, Malibary T. Cerebral venous thrombosis in adults. A study of 40 cases from Saudi Arabia. Stroke 1995; 26: 1193-5.
3 Deschiens MA, Conard J, Horellou MH, Ameri A, Preter M, Chedru F, Samama MM, Bousser MG. Coagulation studies, factor V Leiden, and anticardiolipin antibodies in 40 cases of cerebral venous thrombosis. Stroke 1996; 27: 1724-30.
4 Preter M, Tzourio C, Ameri A, Bousser MG. Long-term prognosis in cerebral venous thrombosis. Follow-up of 77 patients. Stroke 1996; 27: 243-6.
5 Zuber M, Toulon P, Marnet L, Mas JL. Factor V Leiden mutation in cerebral venous thrombosis. Stroke 1996; 27: 1721-3.
6 Martinelli I, Landi G, Merati G, Cella R, Tosetto A, Mannucci PM. Factor V gene mutation is a risk factor for cerebral venous thrombosis. Thromb Haemost 1996; 75: 393-4.
7 Dulli DA, Luzzio CC, Williams EC, Schutta HS. Cerebral venous thrombosis and activated protein C resistance. Stroke 1996; 27: 1731-3.
8 Brey RL, Coull BM. Cerebral venous thrombosis. Role of activated protein C resistance and factor V gene mutation. Stroke 1996; 27: 1719-20.
9 Bridey F, Wolff M, Laissy JP, Morin V, Lefebvre M, de Prost D. Fatal cerebral venous sinus thrombosis associated with the factor V Leiden mutation and the use of oral contraceptives. Thromb Haemost 1995; 74: 1382.
10 Siegert CE, Smelt AH. Activated protein C resistance and factor V Leiden mutation are risk factors for cerebral sinus thrombosis. Stroke 1997; 28: 1291-2.
11 Lüdemann P, Nabavi DG, Junker R, Wolff E, Papke K, Buchner H, Assmann G, Ringelstein EB. Factor V Leiden mutation is a risk factor for cerebral venous thrombosis. Stroke (submitted).
12 Wiman B, Hamsten A. Impaired fibrinolysis and risk of thromboembolism. Prog Cardiovasc Dis 1991; 34: 179-92.
13 Juhan Vague I, Valadier J, Alessi MC, Aillaud MF, Ansaldi J, Philip-Joet C, Holvoet P, Serradimigni A, Collen D. Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosis. Thromb Haemost 1987; 57: 67-72.
14 Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 1993; 268: 10739-45.
15 Eriksson P, Kallin B, van ’t Hooft FM, Bavenholm P, Hamsten A. Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. Proc Natl Acad Sci USA 1995; 92: 1851-5.
16 Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de-Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
17 Falk G, Almqvist A, Nordenhem A, Svensson H, Wiman B. Allele specific PCR for detection of a sequence polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene. Fibrinolysis 1995; 9: 170-4.
18 Dahlbäck B. Resistance to activated protein C caused by the factor V R506Q mutation is a common risk factor for venous thrombosis. Thromb Haemost 1997; 78: 483-8.