Control of Smooth Muscle Cell Proliferation – The Role of the Basement Membrane

Ulf Hedin; Joy Roy; Phan Kiet Tran; Karin Lundmark; Adnan Rahman

doi:10.1055/s-0037-1615548

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(S 01): 23-26
DOI: 10.1055/s-0037-1615548

Commentaries

Schattauer GmbH

Control of Smooth Muscle Cell Proliferation – The Role of the Basement Membrane

Ulf Hedin

¹From the Department of Surgery, Division of Vascular Surgery, Karolinska Hospital, Stockholm, Sweden

,

Joy Roy

¹From the Department of Surgery, Division of Vascular Surgery, Karolinska Hospital, Stockholm, Sweden

,

Phan Kiet Tran

¹From the Department of Surgery, Division of Vascular Surgery, Karolinska Hospital, Stockholm, Sweden

,

Karin Lundmark

¹From the Department of Surgery, Division of Vascular Surgery, Karolinska Hospital, Stockholm, Sweden

,

Adnan Rahman

¹From the Department of Surgery, Division of Vascular Surgery, Karolinska Hospital, Stockholm, Sweden

› Author Affiliations

Abstract

Summary

In atherogenesis and in response to vessel injury, arterial smooth muscle cells (SMCs) are activated from a quiescent, differentiated state into an actively proliferating and synthetic phenotype which migrate into the intima where the cells participate in the formation of a fibrous plaque or intimal hyperplasia. The mechanisms involved in the control of SMC function are not clear and no preventive therapy against SMC activation is available. Interactions between SMCs and the extracellular matrix have been shown to influence SMC structure and function through integrin-mediated signaling processes. The SMC basement membrane is a specific form of extracellular matrix which seems to be crucial for the maintenance of SMC quiesence and the disruption of these interactions is part of cellular activation after atherogenic or traumatic stimuli. This concept of “negative growth control” may constitute a future target for the development of new strategies in the prevention of SMC activation in atherogenesis and restenosis formation.

Key words

Smooth muscle cells - restenosis - atherogenesis - cellular activation - basement membrane - integrins

Full Text

References

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