Taking the Hype out of Hyperfibrinogenaemia?

Fiona R. Green

doi:10.1055/s-0037-1616078

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(02): 509-510
DOI: 10.1055/s-0037-1616078

Commentary

Schattauer GmbH

Taking the Hype out of Hyperfibrinogenaemia?

Authors

Fiona R. Green

¹Dept. Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Headington, Oxford, UK

Abstract

Full Text

References

References
1 Green FR. Fibrinogen polymorphisms and athero-thrombotic disease. Annals of the New York Academy of Sciences. 2001 (in press).
2 Suh TT, Holmback K, Jensen NJ, Daugherty CC, Small K, Simon DI. et al. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev 1995; 9: 2020-33.
3 Xiao Q, Danton MJ, Witte DP, Kowala MC, Valentine MT, Degen JL. Fibrinogen deficiency is compatible with the development of atherosclerosis in mice. J Clin Invest 1998; 101: 1184-94.
4 Lou XJ, Boonmark NW, Horrigan FT, Degen JL, Lawn RM. Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice. Proc Natl Acad Sci USA 1998; 95: 12591-5.
5 Holmback K, Danton MJ, Suh TT, Daugherty CC, Degen JL. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. Embo J 1996; 15: 5760-71.
6 Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO. et al. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest 2000; 106: 385-92.
7 Palumbo JS, Kombrinck KW, Drew AF, Grimes TS, Kiser JH, Degen JL. et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 2000; 96: 3302-9.
8 Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WR. et al. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 2: 533-7.
9 Meade TW, Ruddock V, Stirling Y, Chakrabarti R, Miller GJ. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 1993; 342: 1076-9.
10 Yu S, Sher B, Kudryk B, Redman CM. Intracellular assembly of human fibrinogen. J Biol Chem 1983; 258: 13407-10.
11 Roy SN, Mukhopadhyay G, Redman CM. Regulation of fibrinogen assembly. Transfection of Hep G2 cells with B beta cDNA specifically enhances synthesis of the three component chains of fibrinogen. J Biol Chem 1990; 265: 6389-93.
12 Rezaee F, Maas A, Verheijen J, Koopman J. Generation and characterization of transgenic mice with overexpression of fibrinogen Bβ-chain and mRNA. Thromb Haemost 1999; 82 (Suppl. 01) 424-5 (Abstr 1343).
13 Prunkard D, Cottingham I, Garner I, Bruce S, Dalrymple M, Lasser G. et al. High-level expression of recombinant human fibrinogen in the milk of transgenic mice. Nat Biotechnol 1996; 14: 867-71.
14 Butler SP, van Cott K, Subrumanian A, Gwazduaskas FC, Velander WH. Current progress in the production of recombinant human fibrinogen in the milk of transgenic animals. Thromb Haemost 1997; 78 State of the Art 537-42.