Interendothelial Junctions and their Role in the Control of Angiogenesis, Vascular Permeability and Leukocyte Transmigration

Elisabetta Dejana; Raffaella Spagnuolo; Gianfranco Bazzoni

doi:10.1055/s-0037-1616228

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(01): 308-315
DOI: 10.1055/s-0037-1616228

Research Article

Schattauer GmbH

Interendothelial Junctions and their Role in the Control of Angiogenesis, Vascular Permeability and Leukocyte Transmigration

Elisabetta Dejana

¹Istituto di Ricerche Farmacologiche Mario Negri

²FIRC Institute of Molecular Oncology, Milano, Italy

³Università degli Studi dell’Insubria, Dipartimento di Scienze Cliniche e Biologiche, Facoltà di Medicina e Chirurgia, Varese, Italy

,

Raffaella Spagnuolo

¹Istituto di Ricerche Farmacologiche Mario Negri

²FIRC Institute of Molecular Oncology, Milano, Italy

,

Gianfranco Bazzoni

¹Istituto di Ricerche Farmacologiche Mario Negri

› Author Affiliations

Abstract

Summary

Endothelial cell-cell junctions play an important role in vascular hemostasis. The two junctional proteins VE-cadherin and JAM-1 are localized at adherens and tight junctions, respectively. VE-cadherin is only expressed by endothelial cells, suggesting that it can exert cell specific function. Absence of VE-cadherin or blocking of its adhesive activity prevents a normal organization of new vascular structures, suggesting that VE-cadherin may be a molecular target of antiangiogenic therapy. In addition, the ability of permeability-increasing agents and adherent leukocytes to modify VE-cadherin/catenin organization may be related to a role in the control of vascular permeability and leukocyte infiltration. JAM-1 is an integral membrane protein expressed in endothelial and epithelial cells. Its extracellular domain can dimerize and bind homophilically. The intracellular domain (and in particular a PDZ-binding motif) enables JAM-1 to interact with structural and signaling proteins. Study of the molecular interactions of JAM-1 may help explain mechanisms of JAM-mediated function, such as control of paracellular permeability and leukocyte transmigration.

Key words

Endothelium - angiogenesis - permeability - inflammation - adherens and tight junctions

Full Text

References

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