Hamostaseologie 2016; 36(03): 159-160
DOI: 10.1055/s-0037-1616863
Editorial
Schattauer GmbH

Molecular complexity of the megakaryocyte-platelet system in health and disease

Rüdige E. Scharf
1   Dept. of Experimental and Clinical Hemostasis, Hemotherapy and Transfusion Medicine, Heinrich Heine University Medical Center, Düsseldorf
2   Hemophilia Comprehensive Care Center, Heinrich Heine University Medical Center, Düsseldorf
2   Hemophilia Comprehensive Care Center, Heinrich Heine University Medical Center, Düsseldorf
› Author Affiliations
Further Information

Publication History





Publication Date:
29 December 2017 (online)

 

 
  • References

  • 1 Sanchez C, Lachaize C, Janody F. et al. Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database. Nucleic acids research 1999; 27: 89-94.
  • 2 Hein MY, Hubner NC, Poser I. et al. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 2015; 163: 712-723.
  • 3 Sastry SK, Burridge K. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Experimental cell research 2000; 261: 25-36.
  • 4 Geiger B, Bershadsky A. Assembly and mechanosensory function of focal contacts. Current opinion in cell biology 2001; 13: 584-592.
  • 5 Boureux A, Vignal E, Faure S, Fort P. Evolution of the Rho family of ras-like GTPases in eukaryotes. Molecular biology and evolution 2007; 24: 203-216.
  • 6 Bustelo XR, Sauzeau V, Berenjeno IM. GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. BioEssays : news and reviews in molecular, cellular and developmental biology 2007; 29: 356-370.
  • 7 Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nature reviews Molecular cell biology 2008; 9: 690-701.
  • 8 Scharf RE. Platelet pathology and vascular medicine. Hämostaseologie 2015; 35: 9.
  • 9 Scharf RE. Von Willebrand factor, hemostasis and inflammation. Hämostaseologie 2015; 35: 209-210.
  • 10 Scharf RE. Coagulation disorders. Recent lessens from clinical conditions. Hämostaseologie 2015; 35: 301-302.
  • 11 Scharf RE. Platelet pathology and antiplatelet strategies. Resolved and unresolved issues. Hämostaseologie 2016; 36: 7-8.
  • 12 Scharf RE. Atherogenesis – tried and tested pieces in the puzzle. Hämostaseologie 2016; 36: 73-74.
  • 13 Laffan M. A whole genome approach to platelet and bleeding disorders. Hämostaseologie 2016; 36: 161-166.
  • 14 Elvers M. RhoGAPs and Rho GTPases in platelets. Hämostaseologie 2016; 36: 168-177.
  • 15 Niermann C, Gorressen S, Klier M. et al. Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis. Cellular signalling 2016; 28: 967-978.
  • 16 Sandrock-Lang K, Wentzell R, Santoso S, Zieger B. Inherited platelet disorders. Hämostaseologie 2016; 36: 178-186.
  • 17 Dell’Angelica EC, Shotelersuk V, Aguilar RC, Gahl WA, Bonifacino JS. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. Molecular cell 1999; 3: 11-21.
  • 18 Dell’Angelica EC. AP-3-dependent trafficking and disease: the first decade. Current opinion in cell biology 2009; 21: 552-559.
  • 19 Nugent D, McMillan R, Nichol JL, Slichter SJ. Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production. British journal of haematology 2009; 146: 585-596.
  • 20 Bakchoul T, Sachs UJ. Platelet destruction in immune thrombocytopenia. Hämostaseologie 2016; 36: 187-194.