Leptin – ein Botenstoff mit vielfältigen Funktionen in der Reproduktionsund Ernährungsphysiologie landwirtschaftlicher Nutztiere

Zusammenfassung

Die Bedeutung von Leptin und seinem Rezeptor wurde zunächst für die Humanphysiologie erkannt. Grundlegende Erkenntnisse aus diesem Forschungsgebiet konnten anschließend auf dem veterinärmedizinischen Sektor bestätigt und verifiziert werden. Von besonderem Interesse sind hierbei die Beeinflussung des Energie- und Fettstoffwechsels sowie die Modulation des Reproduktionsgeschehens. Da die Wirkung von Leptin nicht isoliert betrachtet werden kann, sondern immer in einem engen Zusammenhang mit den anderen Gliedern in diesen Hormonsystemen zu sehen ist, lassen sich praxisrelevante Erfolge schwerer erzielen als ursprünglich angenommen. Trotzdem stellen Leptin und sein Rezeptor ein interessantes und hochkomplexes Hormonsystem dar, das nach weiterer deskriptiver und grundlagenorientierter Forschung in den kommenden Jahren durchaus in den Mittelpunkt des Praxisinteresses rücken könnte.

Summary

The impact of leptin and its receptor was first acknowledged in human physiology. Basic insights could later be confirmed in the field of veterinary medicine. Especially the manipulation of energy and fat metabolism and the modulation of reproductive function are of high scientific and practical interest. As the function of leptin can not be regarded solely but has to be seen in close context with other members of the hormone cascades, successes with practical impact could not be gained as fast as expected. Nevertheless, leptin and its receptor are a highly complex hormone system, which after further descriptive and basic research, can come into the focus of practical application in the future.

Schlüsselwörter

Energiestoffwechsel - Leptin - Leptinrezeptor - Reproduktionsphysiologie

Keywords

Energy metabolism - Leptin - Leptin receptor - Physiology of reproduction

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