Kongenitales embryonales Rhabdomyosarkom am Kopf eines rotbunten Deutsche-Holstein-Kalbes

Zusammenfassung

Tumoren mit Skelettmuskeldifferenzierung sind bei den Haussäugetieren nur sehr selten zu beobachten. Es werden benigne Rhabdomyome von malignen Rhabdomyosarkomen unterschieden. Bei einem weiblichen Kalb der Rasse Deutsche Holstein wurde eine kongenitale, kugelförmige Umfangsvermehrung lateral in der Unterhaut des Kopfes festgestellt. Histologisch bestand die abgekapselte, expansive, zellreiche Umfangsvermehrung aus einem retikulären Maschenwerk kleiner, mäßig pleomorpher, spindelförmiger bis rundlicher Zellen in einem fibrovaskulären bis myxoiden Stroma sowie multifokalen, großen, plumpen, mehrkernigen, Myotuben-ähnlichen Zellen (strap cells). Mittels elektronenmikroskopischer Untersuchung wurden in den strap cells charakteristische zytoplasmatische Bündel von Myofilamenten und Z-Streifen nachgewiesen. Die kleinen spindelförmigen Zellen zeigten eine Immunreaktivität für Vimentin und die strap cells für Desmin. Die vorliegenden Ergebnisse entsprechen dem Befundspektrum eines bovinen kongenitalen embryonalen Rhabdomyosarkoms.

Summary

Tumours with skeletal-muscle differentiation are rare in companion animals. They are differentiated into benign rhabdomyomas and malignant rhabdomyosarcomas. A female German Holstein calf displayed a congenital, spherical, subcutaneous mass at the lateral side of the head. Histology revealed an encapsulated, expansile, highly cellular mass consisting of a reticular meshwork of moderately pleomorphic, small spindle-shaped to round cells within a fibrovascular to myxoid stroma as well as multifocal, large, blunt, multinucleated myotube-like cells (strap cells). Electron microscopy demonstrated characteristic cytoplasmic bundles of myofilaments and Z-stripes within the strap cells. Immunoreactivity for vimentin was observed in the small spindle-shaped cells and for desmin in the strap cells. The results are consistent with the spectrum of findings characteristic for a bovine congenital embryonal rhabdomyosarcoma.

Schlüsselwörter

Elektronenmikroskopie - Immunhistologie - Histologie - Neoplasie - Skelettmuskulatur - Rind

Key words

Bovine - electron microscopy - immunohistology - histology - neoplasia - skeletal muscle

• Literatur

• 1 Aoyagi T, Saruta K, Asahi I, Hojo H, Shibahara T, Kadota K. Pleomorphic rhabdomyosarcoma in a cow. J Vet Med Sci 2001; 63: 107-110.
• 2 Bisby TM, Pratt SM, Fenton RK, Baird AN, Thompson CA, Lin TL. What is your diagnosis? Perifemoral mass in a cow. Vet Clin Pathol 2009; 38: 343-347.
• 3 Cooper BJ, Valentine BA. Tumor of muscle. In: Tumors in Domestic Animals. Meuten DJ. ed. Ames, IA: Iowa State Press; 2002: 319-363.
• 4 Dennis MM, McSporran KD, Bacon NJ, Schulman FY, Foster RA, Powers BE. Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs. Vet Pathol 2011; 48: 73-84.
• 5 Hendrick MJ, Mahaffey EA, Moore FM, Vos JH, Walder EJ. Histological classification of mesenchymal tumors of skin and soft tissues of domestic animals. Washington, D.C.: American Registry of Pathology; 1998
• 6 Herfen K, Atzpodien E. Ein embryonales Rhabdomyosarkom bei einem Texelschaflamm. Tierärztl Prax 1999; 27 (G): 87-91.
• 7 Jimma K, Wada Y, Ishikawa Y, Kadota K. Differentiated embryonal rhabdomyosarcoma in a cow. J Vet Med Sci 1999; 61: 577-580.
• 8 Kajiwara A, Tani N, Kobayashi Y, Furuoka H, Sasaki N, Ishii M, Inokuma H. Rhabdomyosarcoma with posterior paresis and megaesophagus in a Holstein heifer. J Vet Med Sci 2009; 71: 827-829.
• 9 Kapadia SB, Parham DM, Barr FG, Montgomery E. Skeletal muscle tumors. In: World Health Organization classification of tumors: Pathology and genetics of tumors of soft tissue and bone. Fletcher CDM, Unni KK, Mertens F. eds. Lyon: IARC Press; 2002: 146-149.
• 10 Liggett AD, Weiss R, Thomas KL. Canine laryngopharyngeal rhabdomyoma resembling an oncocytoma: light microscopic, ultrastructural and comparative studies. Vet Pathol 1985; 22: 526-532.
• 11 Matsui T, Imai T, Han JS, Awakura T, Taniyama H, Osame S, Nakagawa M, Ono T. Bovine undifferentiated alveolar rhabdomyosarcoma and its differentiation in xenotransplanted tumors. Vet Pathol 1991; 28: 438-445.
• 12 Meyerholz DK, Caston SS, Haynes JS. Congenital fetal rhabdomyoma in a foal. Vet Pathol 2004; 41: 518-520.
• 13 Puff C, Kehler W, Baumgärtner W, Herden C. Malignant mesenchymoma in the nasal cavity of a bull. J Comp Pathol 2011; 145: 148-151.
• 14 Toth B, Patil K, Erickson J, Gannett P. Carcinogenesis by benzenediazonium sulfate in mice. In Vivo 1998; 12: 379-382.
• 15 Ulrich R, Stan AC, Koch A, Beineke A. Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. Vet Pathol 2008; 45: 355-360.
• 16 van der Loop FT, Bosma AA, Vos JH, Mirck MH, Schaart G, van den Ingh TS, Ramaekers FC. Cultured pig rhabdomyosarcoma cells with a deletion of the Xq24-qter chromosome region: an immunochemical and cytogenetic characterization. Am J Vet Res 1995; 56: 1062-1069.
• 17 Van Vleet JF, Valentine BA. Neoplastic diseases of muscle. In: Jubb, Kennedy, and Palmer’s pathology of domestic animals. Maxie MG. ed. Edinburgh, UK: Elsevier; 2007: 272-277.