Rubber jaw in a Weimaraner dog due to juvenile nephropathy

Summary

The case of a 5-month-old male Weimaraner dog with severe osteodystrophia fibrosa (rubber jaw) and renal insufficiency is presented. Kidneys were smaller than normal with a granular cortical surface and a histopathological end-stage diagnosis consistent with juvenile nephropathy. Analysis of four described genetic mutations associated with Alport syndrome in dogs revealed no evidence for familiar inheritance in this dog.

Zusammenfassung

Vorgestellt wird der Fall eines 5 Monate alten Weimaraner-Welpen mit schwerer Osteodystrophia fibrosa (rubber jaw) und einer ausgeprägten Niereninsuffizienz. Bei der pathologischen Untersuchung zeigten sich bilateral Schrumpfnieren im Sinne einer juvenilen Nephropathie. Die molekularbiologische Untersuchung der vier bekannten, in der Literatur beschriebenen Genmutationen, die mit dem Alport-Syndrom des Hundes assoziiert sind, ergab keinen Hinweis auf eine hereditäre Pathogenese.

Key words

Osteodystrophia fibrosa - renal insufficiency - end-stage kidney - Alport syndrome

Schlüsselwörter

Osteodystrophia fibrosa - Niereninsuffizienz - Schrumpfniere - AlportSyndrom

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