Biokinetics and Metabolism of Radiogallium^[*]

Summary

The large number of publications dealing with biokinetics, metabolism and factors influencing tissue uptake of ⁶⁷Ga-citrate could not clarify the mechanism responsible for the uptake of this compound into tumor tissue. The present paper reviews biokinetic data obtained from clinical investigations and animal experiments and briefly points out some possible pathways of the mechanism for gallium localisation in tumors as well as in abscesses and inflammatory lesions.

Zusammenfassung

Zur Biokinetik von Gallium und über die Gallium-Anreicherung in Tumoren liegen bereits eine relativ große Anzahl von klinischen und tierexperimentellen Untersuchungen vor. Die daraus hervorgegangenen Einzeldaten ergaben bisher jedoch keine endgültige Klärung sondern lediglich Hinweise auf die möglichen Grundmechanismen bei der Anreicherung von Gallium in Tumoren. Die vorliegende Arbeit gibt einen Überblick über die Biokinetik von Gallium und stellt die möglichen Anreicherungsmechanismen in Tumorzellen in Kürze dar.

^* 3rd International Symposium on Radiopharmacology, Freiburg i. Br., September 1983.

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