Ergebnisse der Fettsäure-SPECT des Myokards bei der koronaren Herzerkrankung

S. N. Reske; F. F. Knapp; J. Nitsch; J. Kropp; K. Reichmann; C. Winkler

doi:10.1055/s-0038-1624324

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1986; 25(03): 90-98
DOI: 10.1055/s-0038-1624324

Originalarbeiten - Original Articles

Schattauer GmbH

Ergebnisse der Fettsäure-SPECT des Myokards bei der koronaren Herzerkrankung

Results of Myocardial SPECT with Fatty Acids in Coronary Artery Disease

Authors

S. N. Reske
F. F. Knapp

^*Universität Bonn, Bundesrepublik Deutschland, und Nuclear Medicine Group, Oak Ridge National Laboratory (ORNL), Oak Ridge, TN., USA
J. Nitsch

^**Aus dem Institut für klinische und experimentelle Nuklearmedizin, Med Klinik, Kardiologie, Oak Ridge National Laboratory (ORNL), Oak Ridge, TN., USA
J. Kropp
K. Reichmann
C. Winkler

Abstract

New developments in radiopharmacology of ¹²³l-labeled metabolic tracers and single-photon emission computerized tomography (SPECT) allow now-a-days the assessment of parameters of cardiac energy metabolism in well-defined areas of the heart muscle. This article will present a brief outline of the basic pathophysiological principles used in the application of ¹²³l-labeled phenyl fatty acids for the evaluation of CAD. First clinical results suggest an important application of cardiac fatty acid metabolic imaging to the detection, localisation and conceivable quantitation of myocardial ischemia, myocardial infarction and assessment of tissue viability. In addition to the diagnostic applications in CAD, cardiac fatty acid metabolic imaging may provide new perspectives to pathophysiological investigations of the coupling of local flow and substrate utilisation in vivo and the effect of therapeutic interventions.

Zusammenfassung

Neue Entwicklungen in der Radiopharmakologie ¹²³J-markierter myokardaffiner Stoffwechsel-Tracer und die Single-Photon-Emissions-Computer-Tomographie haben die Untersuchung von Parametern des myokardialen Energiestoffwechsels in definierten Arealen des Herzmuskels möglich gemacht. Die vorliegende Arbeit gibt einen kurzen Abriß über pathophysiologische Prinzipien und Grundlagen der Anwendung ¹²³J-markierter Fettsäuren in der Diagnostik der koronaren Herzerkrankung in Verbindung mit SPECT. Erste klinische Ergebnisse zeigen die Möglichkeit des Nachweises, der Lokalisation und vielleicht auch der Quantifizierung des Myokardinfarktes, der reversiblen Myokardischämie sowie des Nachweises der Gewebsvitalität. Neben der Anwendung in der Diagnostik der koronaren Herzerkrankung eröffnet das geschilderte Untersuchungsverfahren neue Perspektiven für pathophysiolo- gische Untersuchungen der Koppelung von Fluß und Stoffwechsel des Herzmuskels und deren therapeutische Beeinflußbarkeit in einem Untersuchungsgang.

Full Text

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