Botulinumtoxintherapie

H. Hefter

doi:10.1055/s-0038-1627634

Nervenheilkunde, Table of Contents

Nervenheilkunde 2015; 34(10): 791-797
DOI: 10.1055/s-0038-1627634

Update Neurologie und Psychiatrie

Schattauer GmbH

Botulinumtoxintherapie

Botulinum neurotoxin therapy

Authors

H. Hefter

¹Neurologische Klinik des Universitätsklinikums Düsseldorf

Abstract

Zusammenfassung

Botulinumtoxin-A (BTX-A) weist ein enorm breites Indikationsspektrum auf. In den vergangenen Jahren wurde BTX-A auch für die Behandlung der chronischen Migräne und des spastischen Spitzfußes zugelassen. BTX-A kann also vom Kopf bis zum Fuß angewendet werden. Erstaunlicherweise sprechen sogar Symptome wie die Depression auf die äußerliche Anwendung von BTX-A an. Das Spektrum der Symptome, auf die BTX eine Wirkung zeigt, ist noch sehr viel breiter als das Spektrum der zugelassenen Indikationen. Je mehr aber BTX-A angewendet wird, desto wichtiger ist es, Immunität gegen BTX zu vermeiden, denn die Induktion von neutralisierenden Antikörpern ist der wesentliche limitierende Faktor in der Langzeitanwendung von BTX. Mit der vorliegenden Übersicht sollen einige der neuen Aspekte der BTX-A-Therapie etwas intensiver beleuchtet werden.

Summary

Botulinum neurotoxin type A (BTX-A) therapy covers a wide range of indications. Meanwhile, BTX-A is also licensed for the treatment of chronic migraine as well as the spastic drop foot. Thus BTX-A can be applied from the head to the foot. It does not only have beneficial effects on muscle hyperactivity and muscular hypertension but can also be used for the treatment of pain syndromes. Furthermore, BTX-A injections to the face also improve depression. Indeed, it is really fascinating to see, which symptoms respond to BTX-A injections. Therefore it is highly relevant to take into account and to analyze antibody formation in detail, since the development of neutralizing antibodies is the most limiting factor in BTX long-term therapy. The following up-date will highlight some of the above mentioned aspects of BTX-A application.

Schlüsselwörter

Migräne - Depression - Cap/Col-Konzept - spastischer Spitzfuß - Antikörperbildung

Keywords

Migraine - depression - Cap/Col-concept - spastic drop foot - neutralizing antibodies

Full Text

References

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