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Nervenheilkunde 2013; 32(08): 532-537
DOI: 10.1055/s-0038-1628538
Ulmer Heft
Schattauer GmbH

Hypertrophe Degeneration des Nucleus olivaris

Klinisches BildHypertrophic olivary degenerationClinical correlates
H. Graf
1   Klinik für Psychiatrie und Psychotherapie III, Universitätsklinik Ulm
,
M. Gorges
2   Neurologische Universitätsklinik Ulm
,
J. Kassubek
2   Neurologische Universitätsklinik Ulm
› Author Affiliations
Further Information

Publication History

eingegangen am: 20 April 2013

angenommen am: 06 May 2013

Publication Date:
23 January 2018 (online)

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Zusammenfassung

Die hypertrophe Degeneration der Oliven (HOD) ist eine seltene Form der Neuroplastizität, die als Folge von Läsionen des anatomisch-funktionellen Regelkreises des Guillan-Mollaret-Dreiecks, bestehend aus dem Nucleus ruber, dem ipsilateralen Nucleus olivaris inferior (ION) und dem kontralateralen Nucleus dentatus, auftritt. Dieser Artikel zeigt eine Übersicht der Literatur der HOD unter Berücksichtigung ätiologischer, pathophysiologischer und klinischer Aspekte. Darüber hinaus berichten wir von einem Patienten mit HOD, der mittels Videookulografie untersucht wurde.

Summary

Hypertrophic olivary degeneration (HOD) is a rare variant of trans-synaptic neuroplasticity that occurs secondary after focal lesions of the neurofunctional pathway referred to as the “Guillan-Mollaret triangle”, consisting of the red nucleus, the ipsilateral inferior olivary nucleus and contralateral cerebellar dentate nucleus. We present a case of a 55-year old patient with HOD along with Holmes`-Tremor and spontaneous nystagmus after a pontine haemorrhage including a detailed examination by means of videooculography. Moreover, we provide an overview of the recent literature regarding hypertrophic olivary degeneration and associated clinical symptoms.

Schlüsselwörter

Hypertrophe oliväre Degeneration - Holmes` Tremor - Nystagmus

Keywords

Hypertrophic olivary degeneration - Holmes` Tremor - nystagmus
 

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