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Nervenheilkunde 2009; 28(04): 1-4
DOI: 10.1055/s-0038-1628610
DOI: 10.1055/s-0038-1628610
Thema zum Schwerpunkt
Genetik
Authors
Further Information
Publication History
Publication Date:
24 January 2018 (online)
-
Literatur
- 1 Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003; 08 (07) 646-653.
- 2 Arango V, Ernsberger P, Marzuk PM, Chen JS, Tierney H, Stanley M. et al. Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiatry 1990; 47 (11) 1038-1047.
- 3 Arango V, Huang YY, Underwood MD, Mann JJ. Genetics of the serotonergic system in suicidal behavior. J Psychiatr Res 2003; 37 (05) 375-386.
- 4 Arango V, Underwood MD, Mann JJ. Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. Biol Psychiatry 1996; 39 (02) 112-120.
- 5 Arango V, Underwood MD, Mann JJ. Postmortem findings in suicide victims. Implications for in vivo imaging studies. Ann N Y Acad Sci 1997; 836: 269-287.
- 6 Asberg M. Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies. Ann N Y Acad Sci 1997; 836: 158-181.
- 7 Baldessarini RJ, Hennen J. Genetics of suicide: an overview. Harv Rev Psychiatry 2004; 12 (01) 1-13.
- 8 Bellivier F, Chaste P, Malafosse A. Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2004; 124B (01) 87-91.
- 9 Biegon A, Fieldust S. Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims. Synapse 1992; 10 (01) 79-82.
- 10 Bondy B, Baghai TC, Minov C, Schule C, Schwarz MJ, Zwanzger P. et al. Substance P serum levels are increased in major depression: preliminary results. Biol Psychiatry 2003; 53 (06) 538-542.
- 11 Bondy B, Buettner A, Zill P. Genetics of suicide. Mol Psychiatry 2006; 11 (04) 336-351.
- 12 Bondy B, Kuznik J, Baghai T, Schule C, Zwanzger P, Minov C. et al. Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide. Am J Med Genet 2000; 96 (06) 831-835.
- 13 Brent DA, Johnson BA, Perper J, Connolly J, Bridge J, Bartle S. et al. Personality disorder, personality traits, impulsive violence, and completed suicide in adolescents. J Am Acad Child Adolesc Psychiatry 1994; 33 (08) 1080-1086.
- 14 Brent DA, Mann JJ. Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet 2005; 133C (01) 13-24.
- 15 Bronisch T, Brunner J, Bondy B, Rujescu D, Bishof G, Heuser I, Müller-Oerlinghausen B, Hawellek B, Maier W, Rao ML, Felber W, Lewitzka U, Oehler J, Broocks A, Hohagen F, Lauterbach E. A multicenter study about Neurobiology of Suicidal Behavior: design, development, and preliminary results. Arch Suicide Res 2005; 09 (01) 19-26.
- 16 Brunner HG, Nelen MR, van Zandvoort P, Abeling NG, van Gennip AH, Wolters EC. et al. X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. Am J Hum Genet 1993; 52 (06) 1032-1039.
- 17 Brunner J, Bronisch T. [Neurobiological correlates of suicidal behavior]. Fortschr Neurol Psychiatr 1999; 67 (09) 391-412.
- 18 Brunner J, Parhofer KG, Schwandt P, Bronisch T. Cholesterol, essential fatty acids, and suicide. Pharmacopsychiatry 2002; 35 (01) 1-5.
- 19 Buchsbaum MS, Coursey RD, Murphy DL. The biochemical high-risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity. Science 1976; 194 (4262): 339-341.
- 20 Burgess DL, Kohrman DC, Galt J, Plummer NW, Jones JM, Spear B. et al. Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’. Nat Genet 1995; 10 (04) 461-465.
- 21 Cao L, Li T, Xu K, Liu X. [Association analysis of attempted suicide and 5-HT2A receptor gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2001; 18 (03) 195-197.
- 22 Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW. et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297 (5582): 851-854.
- 23 Coursey RD, Buchsbaum MS, Murphy DL. Platelet MAO activity and evoked potentials in the identification of subjects biologically at risk for psychiatric disorders. Br J Psychiatry 1979; 134: 372-381.
- 24 Crawford J, Sutherland GR, Goldney RD. No evidence for association of 5-HT2A receptor polymorphism with suicide. Am J Med Genet 2000; 96 (06) 879-880.
- 25 Crawford J, Zielinski MA, Fisher LJ, Sutherland GR, Goldney RD. Is there a relationship between Wolfram syndrome carrier status and suicide?. Am J Med Genet 2002; 114 (03) 343-346.
- 26 De Luca V, Mueller DJ, Tharmalingam S, King N, Kennedy JL. Analysis of the novel TPH2 gene in bipolar disorder and suicidality. Mol Psychiatry 2004; 09 (10) 896-897.
- 27 De Luca V, Voineskos D, Wong GW, Shinkai T, Rothe C, Strauss J. et al. Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality. Psychiatry Res 2005; 134 (02) 195-198.
- 28 Dervic K, Grunebaum MF, Burke AK, Mann JJ, Oquendo MA. Cluster C personality disorders in major depressive episodes: the relationship between hostility and suicidal behavior. Arch Suicide Res 2007; 11 (01) 83-90.
- 29 Dietrich PS, McGivern JG, Delgado SG, Koch BD, Eglen RM, Hunter JC. et al. Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia. J Neurochem 1998; 70 (06) 2262-2272.
- 30 Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 2000; 96 (01) 56-60.
- 31 Du L, Faludi G, Palkovits M, Sotonyi P, Bakish D, Hrdina PD. High activity-related allele of MAO-A gene associated with depressed suicide in males. Neuroreport 2002; 13 (09) 1195-1198.
- 32 Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003; 60 (08) 804-815.
- 33 Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM. et al. Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Neuron 2000; 25 (01) 203-214.
- 34 Finckh U, Rommelspacher H, Kuhn S, Dufeu P, Otto G, Heinz A. et al. Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism. Pharmacogenetics 1997; 07 (04) 271-281.
- 35 Frances A, Fyer M, Clarkin J. Personality and suicide. Ann N Y Acad Sci 1986; 487: 281-293.
- 36 Geijer T, Frisch A, Persson ML, Wasserman D, Rockah R, Michaelovsky E. et al. Search for association between suicide attempt and serotonergic polymorphisms. Psychiatr Genet 2000; 10 (01) 19-26.
- 37 Giegling I, Hartmann AM, Moller HJ, Rujescu D. Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene. J Affect Disord 2006; 96 (1–2): 75-81.
- 38 Giegling I, Moreno-De-Luca D, Rujescu D, Schneider B, Hartmann AM, Schnabel A. et al. Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 2008; 147 (03) 308-315.
- 39 Giegling I, Rujescu D, Mandelli L, Schneider B, Hartmann AM, Schnabel A. et al. Tachykinin receptor 1 variants associated with aggression in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 2007; 144B (06) 757-761.
- 40 Giegling I, Rujescu D, Mandelli L, Schneider B, Hartmann AM, Schnabel A. et al. Estrogen receptor gene 1 variants are not associated with suicidal behavior. Psychiatry Res 2008; 160 (01) 1-7.
- 41 Gietl A, Giegling I, Hartmann AM, Schneider B, Schnabel A, Maurer K. et al. ABCG1 gene variants in suicidal behavior and aggression-related traits. Eur Neuropsychopharmacol 2007; 17 (6–7): 410-416.
- 42 Golomb BA. Cholesterol and violence: is there a connection?. Ann Intern Med 1998; 128 (06) 478-487.
- 43 Gross-Isseroff R, Biegon A, Voet H, Weizman A. The suicide brain: a review of postmortem receptor/ transporter binding studies. Neurosci Biobehav Rev 1998; 22 (05) 653-661.
- 44 Gwadry FG, Sequeira A, Hoke G, Ffrench-Mullen JM, Turecki G. Molecular characterization of suicide by microarray analysis. Am J Med Genet C Semin Med Genet 2005; 133C (01) 48-56.
- 45 Hallman J, von Knorring L, Oreland L. Personality disorders according to DSM-III-R and thrombocyte monoamine oxidase activity in type 1 and type 2 alcoholics. J Stud Alcohol 1996; 57 (02) 155-161.
- 46 Hesselbrock V, Dick D, Hesselbrock M, Foroud T, Schuckit M, Edenberg H. et al. The search for genetic risk factors associated with suicidal behavior. Alcohol Clin Exp Res 2004; 28 (5 Suppl): 70S-76S.
- 47 Ho LW, Furlong RA, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder. Am J Med Genet 2000; 96 (01) 36-42.
- 48 Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ. Association study of a brain-derived neurotrophicfactor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 2003; 48 (04) 186-189.
- 49 Hong CJ, Pan GM, Tsai SJ. Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism. Neuropsychobiology 2004; 49 (01) 1-4.
- 50 Hong CJ, Wang YC, Tsai SJ. Association study of angiotensin I-converting enzyme polymorphism and symptomatology and antidepressant response in major depressive disorders. J Neural Transm 2002; 109 (09) 1209-1214.
- 51 Hrdina PD, Demeter E, Vu TB, Sotonyi P, Palkovits M. 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain Res 1993; 614 (1–2): 37-44.
- 52 Huang YY, Battistuzzi C, Oquendo MA, Harkavy-Friedman J, Greenhill L, Zalsman G. et al. Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology. Int J Neuropsychopharmacol 2004; 07 (04) 441-451.
- 53 Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, Mann JJ. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology 2004; 29 (08) 1498-1505.
- 54 Huang YY, Grailhe R, Arango V, Hen R, Mann JJ. Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. Neuropsychopharmacology 1999; 21 (02) 238-246.
- 55 Huang YY, Oquendo MA, Friedman JM, Greenhill LL, Brodsky B, Malone KM. et al. Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. Neuropsychopharmacology 2003; 28 (01) 163-169.
- 56 Johann M, Putzhammer A, Eichhammer P, Wodarz N. Association of the –141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. Am J Med Genet B Neuropsychiatr Genet 2005; 132B (01) 46-49.
- 57 Johns CA, Stanley M, Stanley B. Suicide in schizophrenia. Ann N Y Acad Sci 1986; 487: 294-300.
- 58 Jones G, Zammit S, Norton N, Hamshere ML, Jones SJ, Milham C. et al. Aggressive behaviour in patients with schizophrenia is associated with catecholO-methyltransferase genotype. Br J Psychiatry 2001; 179: 351-355.
- 59 Kashani JH, Goddard P, Reid JC. Correlates of suicidal ideation in a community sample of children and adolescents. J Am Acad Child Adolesc Psychiatry 1989; 28 (06) 912-917.
- 60 Koller G, Bondy B, Preuss UW, Zill P, Soyka M. The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients. Behav Brain Funct 2006; 02: 7.
- 61 Koller G, Engel RR, Preuss UW, Karakesisoglou A, Zill P, Bondy B. et al. Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals. Addict Biol 2005; 10 (03) 269-273.
- 62 Kotler M, Barak P, Cohen H, Averbuch IE, Grinshpoon A, Gritsenko I. et al. Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity. Am J Med Genet 1999; 88 (06) 628-633.
- 63 Kramer MS, Winokur A, Kelsey J, Preskorn SH, Rothschild AJ, Snavely D. et al. Demonstration of the efficacy and safety of a novel substance P (NK1) receptor antagonist in major depression. Neuropsychopharmacology 2004; 29 (02) 385-392.
- 64 Kunugi H, Hashimoto R, Yoshida M, Tatsumi M, Kamijima K. A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. Am J Med Genet B Neuropsychiatr Genet 2004; 129B (01) 44-46.
- 65 Kunugi H, Ishida S, Kato T, Tatsumi M, Sakai T, Hattori M. et al. A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Mol Psychiatry 1999; 04 (04) 393-395.
- 66 Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996; 06 (03) 243-250.
- 67 Lalovic A, Sequeira A, DeGuzman R, Chawky N, Lesage A, Seguin M. et al. Investigation of completed suicide and genes involved in cholesterol metabolism. J Affect Disord 2004; 79 (1–3): 25-32.
- 68 Lalovic A, Turecki G. Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. Am J Med Genet 2002; 114 (05) 533-540.
- 69 Lauterbach E, Brunner J, Hawellek B, Lewitzka U, Ising M, Bondy B, Rao ML, Frahnert C, Rujescu D, Müller-Oerlinghausen B, Schley J, Heuser I, Maier W, Hohagen F, Felber W, Bronisch T. Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior. J Affect Disord 2006; Mar; 91 (01) 57-62.
- 70 Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD. et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 2003; 23 (25) 8788-8799.
- 71 Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S. et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274 (5292): 1527-1531.
- 72 Levitt M, Spector S, Sjoerdsma A, Udenfriend S. Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart. J Pharmacol Exp Ther 1965; 148: 1-8.
- 73 Lewitzka U, Muller-Oerlinghausen B, Felber W, Brunner J, Hawellek B, Rujescu D. et al. Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?. Acta Psychiatr Scand 2008; 117 (01) 41-49.
- 74 Lin PY, Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 2004; 55 (10) 1023-1030.
- 75 Liou YJ, Tsai SJ, Hong CJ, Wang YC, Lai IC. Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology 2001; 43 (01) 11-14.
- 76 Maier W. Genetik suizidalen Verhaltens. In: Wolfersdorf M, Kaschka WP. editors. Suizidalität. Die biologische Dimension. Berlin, Heidelberg: Springer; 1996: 85-95.
- 77 Mann JJ. The neurobiology of suicide. Nat Med 1998; 04 (01) 25-30.
- 78 Mann JJ. A current perspective of suicide and attempted suicide. Ann Intern Med 2002; 136 (04) 302-311.
- 79 Mann JJ. Neurobiology of suicidal behaviour. Nat Rev Neurosci 2003; 04 (10) 819-828.
- 80 Mann JJ, Apter A, Bertolote J, Beautrais A, Currier D, Haas A. et al. Suicide prevention strategies: a systematic review. JAMA 2005; 294 (16) 2064-2074.
- 81 Mann JJ, Henteleff RA, Lagattuta TF, Perper JA, Li S, Arango V. Lower 3H-paroxetine binding in cerebral cortex of suicide victims is partly due to fewer high affinity, non-transporter sites. J Neural Transm 1996; 103 (11) 1337-1350.
- 82 Mann JJ, Stanley M, McBride PA, McEwen BS. Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry 1986; 43 (10) 954-959.
- 83 McGuffin P, Marusic A, Farmer A. What can psychiatric genetics offer suicidology?. Crisis 2001; 22 (02) 61-65.
- 84 Mittendorfer-Rutz E, Rasmussen F, Wasserman D. Familial clustering of suicidal behaviour and psychopathology in young suicide attempters. A register-based nested case control study. Soc Psychiatry Psychiatr Epidemiol 2008; 43 (01) 28-36.
- 85 Müller DJ, Barkow K, Kovalenko S, Ohlraun S, Fangerau H, Kölsch H, Lemke MR, Held T, Nöthen MM, Maier W, Heun R, Rietschel M. Suicide attempts in schizophrenia and affective disorders with relation to some specific demographical and clinical characteristics. Eur Psychiatry 2005; Jan; 20 (01) 65-69.
- 86 New AS, Gelernter J, Goodman M, Mitropoulou V, Koenigsberg H, Silverman J. et al. Suicide, impulsive aggression, and HTR1B genotype. Biol Psychiatry 2001; 50 (01) 62-65.
- 87 Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y. et al. No evidence of an association between 5HT1B receptor gene polymorphism and suicide victims in a Japanese population. Am J Med Genet 2001; 105 (04) 343-345.
- 88 Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y. et al. Lack of an association between 5-HT1A receptor gene structural polymorphisms and suicide victims. Am J Med Genet 2002; 114 (04) 423-425.
- 89 Nolan KA, Volavka J, Czobor P, Cseh A, Lachman H, Saito T. et al. Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatr Genet 2000; 10 (03) 117-124.
- 90 Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y, Ohara K. 5-HT2A receptor gene promoter polymorphism--1438G/A and mood disorders. Neuroreport 1998; 09 (06) 1139-1141.
- 91 Ohtani M, Shindo S, Yoshioka N. Polymorphisms of the tryptophan hydroxylase gene and serotonin 1A receptor gene in suicide victims among Japanese. Tohoku J Exp Med 2004; 202 (02) 123-133.
- 92 Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y. et al. Serotonin 2A receptor gene polymorphism is not associated with completed suicide. J Psychiatr Res 2001; 35 (03) 173-176.
- 93 Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y. et al. No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides. Am J Med Genet 2002; 114 (03) 340-342.
- 94 Ono H, Shirakawa O, Nushida H, Ueno Y, Maeda K. Association between catechol-O-methyltransferase functional polymorphism and male suicide completers. Neuropsychopharmacology 2004; 29 (07) 1374-1377.
- 95 Ordway GA, Smith KS, Haycock JW. Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims. J Neurochem 1994; 62 (02) 680-685.
- 96 Persson ML, Geijer T, Wasserman D, Rockah R, Frisch A, Michaelovsky E. et al. Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus. Psychiatr Genet 1999; 09 (02) 97-100.
- 97 Persson ML, Wasserman D, Geijer T, Jonsson EG, Terenius L. Tyrosine hydroxylase allelic distribution in suicide attempters. Psychiatry Res 1997; 72 (02) 73-80.
- 98 Pitchot W, Hansenne M, Ansseau M. Role of dopamine in non-depressed patients with a history of suicide attempts. Eur Psychiatry 2001; 16 (07) 424-427.
- 99 Pitchot W, Hansenne M, Moreno AG, Ansseau M. Suicidal behavior and growth hormone response to apomorphine test. Biol Psychiatry 1992; 31 (12) 1213-1219.
- 100 Placidi GP, Oquendo MA, Malone KM, Huang YY, Ellis SP, Mann JJ. Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels. Biol Psychiatry 2001; 50 (10) 783-791.
- 101 Pooley EC, Houston K, Hawton K, Harrison PJ. Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes. Psychol Med 2003; 33 (05) 775-783.
- 102 Preuss UW, Koller G, Bahlmann M, Soyka M, Bondy B. No association between suicidal behavior and 5-HT2A-T102C polymorphism in alcohol dependents. Am J Med Genet 2000; 96 (06) 877-878.
- 103 Pucadyil TJ, Chattopadhyay A. Cholesterol modulates ligand binding and G-protein coupling to serotonin(1A) receptors from bovine hippocampus. Biochim Biophys Acta 2004; 1663 (1–2): 188-200.
- 104 Qin P, Agerbo E, Mortensen PB. Suicide risk in relation to family history of completed suicide and psychiatric disorders: a nested case-control study based on longitudinal registers. Lancet 2002; 360 (9340): 1126-1130.
- 105 Reif A, Lesch KP. Toward a molecular architecture of personality. Behav Brain Res 2003; 139 (1–2): 1-20.
- 106 Reist C, Haier RJ, DeMet E, Chicz-DeMet A. Platelet MAO activity in personality disorders and normal controls. Psychiatry Res 1990; 33 (03) 221-227.
- 107 Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86 (04) 1343-1346.
- 108 Rommelspacher H, May T, Dufeu P, Schmidt LG. Longitudinal observations of monoamine oxidase B in alcoholics: differentiation of marker characteristics. Alcohol Clin Exp Res 1994; 18 (06) 1322-1329.
- 109 Roy A. Family history of suicide. Arch Gen Psychiatry 1983; 40 (09) 971-974.
- 110 Roy A, Linnoila M. Alcoholism and suicide. Suicide Life Threat Behav 1986; 16 (02) 244-273.
- 111 Roy A, Segal NL, Centerwall BS, Robinette CD. Suicide in twins. Arch Gen Psychiatry 1991; 48 (01) 29-32.
- 112 Rujescu D, Giegling I, Dahmen N, Szegedi A, Anghelescu I, Gietl A. et al. Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3. Neuropsychobiology 2000; 42 Suppl 1 22-25.
- 113 Rujescu D, Giegling I, Gietl A, Hartmann AM, Moller HJ. A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry 2003; 54 (01) 34-39.
- 114 Rujescu D, Giegling I, Mandelli L, Schneider B, Hartmann AM, Schnabel A. et al. NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits. Am J Med Genet B Neuropsychiatr Genet 2008; 147B (01) 42-48.
- 115 Rujescu D, Giegling I, Sato T, Hartmann AM, Moller HJ. Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and metaanalysis. Biol Psychiatry 2003; 54 (04) 465-473.
- 116 Rujescu D, Giegling I, Sato T, Moller HJ. Lack of association between serotonin 5-HT1B receptor gene polymorphism and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 2003; 116B (01) 69-71.
- 117 Rujescu D, Thalmeier A, Moller HJ, Bronisch T, Giegling I. Molecular genetic findings in suicidal behavior: what is beyond the serotonergic system?. Arch Suicide Res 2007; 11 (01) 17-40.
- 118 Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 1998; 103 (03) 273-279.
- 119 Scanlon SM, Williams DC, Schloss P. Membrane cholesterol modulates serotonin transporter activity. Biochemistry 2001; 40 (35) 10507-10513.
- 120 Schalling D, Asberg M, Edman G, Oreland L. Markers for vulnerability to psychopathology: temperament traits associated with platelet MAO activity. Acta Psychiatr Scand 1987; 76 (02) 172-182.
- 121 Schmidtke A, Bille-Brahe U, DeLeo D, Kerkhof A, Bjerke T, Crepet P. et al. Attempted suicide in Europe: rates, trends and sociodemographic characteristics of suicide attempters during the period 1989–1992. Results of the WHO/EURO Multicentre Study on Parasuicide. Acta Psychiatr Scand 1996; 93 (05) 327-338.
- 122 Schmidtke A, Weinacker B, Fricke S. Epidemiologie von Suiziden und Suizdversuchen in Deutschland. Suizidprophylaxe. 1998. Sonderheft: 37-49.
- 123 Schmitz G, Kaminski WE. ABC transporters and cholesterol metabolism. Front Biosci 2001; 06: D505-D514.
- 124 Schulsinger F. Psychopathy: heredity and environment. Int J Ment Health 1972; I: 190-206.
- 125 Schulsinger F. A family study of suicide. In: Schov M, Stromgren G. editors. Origin, Prevention and Treatment of Affective Disorders. London, New York: Academic Press; 1979: 277-287.
- 126 Sequeira A, Gwadry FG, Ffrench-Mullen JM, Canetti L, Gingras Y, Casero Jr RA. et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 2006; 63 (01) 35-48.
- 127 Sequeira A, Kim C, Seguin M, Lesage A, Chawky N, Desautels A. et al. Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior. Am J Med Genet B Neuropsychiatr Genet 2003; 119B (01) 108-113.
- 128 Sequeira A, Mamdani F, Lalovic A, Anguelova M, Lesage A, Seguin M. et al. Alpha 2A adrenergic receptor gene and suicide. Psychiatry Res 2004; 125 (02) 87-93.
- 129 Serretti A, Calati R, Giegling I, Hartmann AM, Moller HJ, Rujescu D. Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls. J Psychiatr Res. 2008
- 130 Serretti A, Mandelli L, Giegling I, Schneider B, Hartmann AM, Schnabel A. et al. HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers. Am J Med Genet B Neuropsychiatr Genet 2007; 144B (03) 291-299.
- 131 Sibille E, Arango V, Galfalvy HC, Pavlidis P, Erraji-Benchekroun L, Ellis SP. et al. Gene expression profiling of depression and suicide in human prefrontal cortex. Neuropsychopharmacology 2004; 29 (02) 351-361.
- 132 Skidgel RA, Erdos EG. The broad substrate specificity of human angiotensin I converting enzyme. Clin Exp Hypertens A 1987; 09 (2–3): 243-259.
- 133 Stalenheim EG, von Knorring L, Oreland L. Platelet monoamine oxidase activity as a biological marker in a Swedish forensic psychiatric population. Psychiatry Res 1997; 69 (2–3): 79-87.
- 134 Stanley M, Mann JJ. Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1983; 01 (8318): 214-216.
- 135 Statham DJ, Heath AC, Madden PA, Bucholz KK, Bierut L, Dinwiddie SH. et al. Suicidal behaviour: an epidemiological and genetic study. Psychol Med 1998; 28 (04) 839-855.
- 136 Stefulj J, Buttner A, Kubat M, Zill P, Balija M, Eisenmenger W. et al. 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations. Eur Arch Psychiatry Clin Neurosci 2004; 254 (04) 224-227.
- 137 Stefulj J, Buttner A, Skavic J, Zill P, Balija M, Eisenmenger W. et al. Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: association studies in German and Slavic population. Am J Med Genet B Neuropsychiatr Genet 2004; 127B (01) 48-50.
- 138 Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res 1997; 69 (2–3): 71-77.
- 139 Strous RD, Nolan KA, Lapidus R, Diaz L, Saito T, Lachman HM. Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study. Am J Med Genet B Neuropsychiatr Genet 2003; 120B (01) 29-34.
- 140 Swift RG, Sadler DB, Swift M. Psychiatric findings in Wolfram syndrome homozygotes. Lancet 1990; 336 (8716) 667-669.
- 141 Thalmeier A, Dickmann M, Giegling I, Schneider B, Hartmann M, Maurer K. et al. Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims. Int J Neuropsychopharmacol 2008; 11 (02) 217-228.
- 142 Traskman L, Asberg M, Bertilsson L, Sjostrand L. Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 1981; 38 (06) 631-636.
- 143 Tripodianakis J, Markianos M, Sarantidis D, Spyropoulou G, Taktikou V, Bistolaki E. Platelet MAO activity in patients with dysthymic disorder. Psychiatry Res 1998; 78 (03) 173-178.
- 144 Tsai SJ, Hong CJ, Hsu CC, Cheng CY, Liao WY, Song HL. et al. Serotonin-2A receptor polymorphism (102T/C) in mood disorders. Psychiatry Res 1999; 87 (2–3): 233-237.
- 145 Tsai SJ, Hong CJ, Yu YW, Chen TJ, Wang YC, Lin WK. Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder. Neuropsychobiology 2004; 50 (03) 235-238.
- 146 Tsai SJ, Wang YC, Hong CJ, Chiu HJ. Association study of oestrogen receptor alpha gene polymorphism and suicidal behaviours in major depressive disorder. Psychiatr Genet 2003; 13 (01) 19-22.
- 147 Turecki G, Briere R, Dewar K, Antonetti T, Lesage AD, Seguin M. et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry 1999; 156 (09) 1456-1458.
- 148 Turecki G, Sequeira A, Gingras Y, Seguin M, Lesage A, Tousignant M. et al. Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. Am J Med Genet B Neuropsychiatr Genet 2003; 118B (01) 36-40.
- 149 van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. Arch Gen Psychiatry 2008; 65 (09) 1062-71.
- 150 Verkes RJ, Fekkes D, Zwinderman AH, Hengeveld MW, van der Mast RC, Tuyl JP. et al. Platelet serotonin and [3H]paroxetine binding correlate with recurrence of suicidal behavior. Psychopharmacology (Berl) 1997; 132 (01) 89-94.
- 151 Verkes RJ, Pijl H, Meinders AE, van Kempen GM. Borderline personality, impulsiveness, and platelet monoamine measures in bulimia nervosa and recurrent suicidal behavior. Biol Psychiatry 1996; 40 (03) 173-180.
- 152 Volavka J, Kennedy JL, Ni X, Czobor P, Nolan K, Sheitman B. et al. COMT158 polymorphism and hostility. Am J Med Genet B Neuropsychiatr Genet 2004; 127B (01) 28-29.
- 153 Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H. et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003; 299 (5603): 76.
- 154 Wasserman D, Geijer T, Rozanov V, Wasserman J. Suicide attempt and basic mechanisms in neural conduction: relationships to the SCN8A and VAMP4 genes. Am J Med Genet B Neuropsychiatr Genet 2005; 133B (01) 116-119.
- 155 Wei J, Hemmings GP. Lack of evidence for association between the COMT locus and schizophrenia. Psychiatr Genet 1999; 09 (04) 183-186.
- 156 Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol 1999; 39: 19-52.
- 157 Wender PH, Kety SS, Rosenthal D, Schulsinger F, Ortmann J, Lunde I. Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Arch Gen Psychiatry 1986; 43 (10) 923-929.
- 158 Yanagi M, Shirakawa O, Kitamura N, Okamura K, Sakurai K, Nishiguchi N. et al. Association of 14–3–3 epsilon gene haplotype with completed suicide in Japanese. J Hum Genet 2005; 50 (04) 210-216.
- 159 Zalsman G, Braun M, Arendt M, Grunebaum MF, Sher L, Burke AK. et al. A comparison of the medical lethality of suicide attempts in bipolar and major depressive disorders. Bipolar Disord 2006; 08 (5 Pt 2): 558-565.
- 160 Zalsman G, Frisch A, Lewis R, Michaelovsky E, Hermesh H, Sher L. et al. DRD4 receptor gene exon III polymorphism in inpatient suicidal adolescents. J Neural Transm 2004; 111 (12) 1593-1603.
- 161 Zammit S, Jones G, Jones SJ, Norton N, Sanders RD, Milham C. et al. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004; 128B (01) 19-20.
- 162 Zhang HY, Ishigaki T, Tani K, Chen K, Shih JC, Miyasato K. et al. Serotonin2A receptor gene polymorphism in mood disorders. Biol Psychiatry 1997; 41 (07) 768-773.
- 163 Zhou Z, Roy A, Lipsky R, Kuchipudi K, Zhu G, Taubman J. et al. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry 2005; 62 (10) 1109-1118.
- 164 Zill P, Buttner A, Eisenmenger W, Moller HJ, Bondy B, Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry 2004; 56 (08) 581-586.
- 165 Zill P, Preuss UW, Koller G, Bondy B, Soyka M. SNPand haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. Neuropsychopharmacology 2007; 32 (08) 1687-1694.
- 166 Zubenko GS, Maher BS, Hughes III HB, Zubenko WN, Scott SJ, Marazita ML. Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet 2004; 129B (01) 47-54.