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Nuklearmedizin 1991; 30(06): 290-293
DOI: 10.1055/s-0038-1629590
ÜBersichtsartikel - Review Articles
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The Role of the Interaction between Fe(III) and Cell Surface in the Accumulation of 67Ga by Tumor Cells

L. J. Anghileri
1   From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France
,
P. Maleki
1   From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France
,
A. Cordova Martinezi   *
,
M. C. Crone-Escanye
1   From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France
,
J. Robert
1   From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France
› Author Affiliations
Further Information

Publication History

Received: 05 May 1991

Publication Date:
03 February 2018 (online)

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The study of the interaction between complexed iron and tumor cells in the presence of 67Ga-citrate indicates that a phenomenon of iron-binding related to the thermodynamic constant of stability of the iron complex, and a hydrolysis (or anion penetration) of the interaction product determine the uptake of 67Ga. The effects of various parameters such as ionic composition of the medium, nature of the iron complex, time of incubation and number of cells are discussed.

Zusammenfassung

Die Untersuchung der Wechselwirkung zwischen einem Eisenkomplex und Tumorzellen in Gegenwart von 67Ga weist darauf hin, daß ein Phänomen der Eisenbindung, das in Beziehung zur thermodynamischen Stabilitätskonstante des Eisenkomplexes steht, und eine Hydrolyse (oder Anionenpenetration) des Wechselwirkungsprodukts die Aufnahme des 67Ga bestimmen. Die Effekte verschiedener Parameter wie Ionenzusammensetzung des Mediums, Art des Eisenkomplexes, Dauer der Inkubation und Anzahl der Zellen warden besprochen.

* Biochemistry Department, University of Soria, Spain.


 

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