Mastocytosis-induced osteoporosis

G. S. Maier; D. Percic; U. Maus; A. A. Kurth

doi:10.1055/s-0038-1630109

Osteologie, Table of Contents

Osteologie 2013; 22(02): 136-139
DOI: 10.1055/s-0038-1630109

Original and review articles

Schattauer GmbH

Mastocytosis-induced osteoporosis

Rare but severeMastozytose-induzierte Osteoporose Eine seltene, aber dennoch nicht zu unterschätzende Krankheit

G. S. Maier

¹Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Gießen, Germany

²Department of Orthopedic Surgery, Johannes-Gutenberg-University, Mainz, Germany

,

D. Percic

²Department of Orthopedic Surgery, Johannes-Gutenberg-University, Mainz, Germany

,

U. Maus

³Orthopedic center Oldenburger Münsterland, St. Antonius-Stift Emstek, Emstek, Germany

,

A. A. Kurth

⁴Mainz, Germany

› Author Affiliations

Abstract

Summary

Background: Systemic mastocytosis is a rare disease characterised by accumulation of mast cells in at least one extracutaneous organ, including bone marrow. It is increasingly recognized as a possible cause of secondary osteoporosis. We conducted a literature review on the role of mast cells in osteoporosis including data/peer reviewed articles/ journals from 1957 to 2012. Our aim was to evaluate the current state of research and to offer an overview of current therapeutic options/measures/treatments.

Methods: A retrospective review of peer r eviewed/published literature was performed using MEDLINE databases from 1957 to 2012. The keywords “osteoporosis” and “mast cells/mastocytosis” revealed 201 articles, limi ted to English and German articles. The following criteria were included: studies on, or case studies of either mastocytosis induced osteoporosis, or the role of mast cells in osteoporosis or the relation of bone remodeling and mastocytosis.

Results/Conclusion: Mast cells seem to play an important role in bone turnover. Their byproducts are responsible for increased bone resorption. However, the skeletal involvement is mainly situated in trabecular bone, which determines vertebral collapse. This review increases the awareness that patients with systemic mastocytosis would benefit from diagnostic workup with regard to bone health, as this rather rare cause of secondary osteoporosis can lead to significantly high rates of mortality.

Zusammenfassung

Hintergrund: Die systemische Mastozytose ist eine seltene Erkrankung, die durch die abnorme Mastzellproliferation in wenigstens einem extrakutanem Gewebe, unter anderem auch im Knochenmark, charakterisiert wird. Die Rolle der Mastzellen und ihrer Mediatoren als potenzielle Ursachen sekundärer Osteoporose wird zunehmend diskutiert. Mit dieser Literaturübersicht der Jahre 1957 bis 2012 wollten wir sowohl den aktuellen Stand der Wissenschaft als auch mögliche Therapieoptionen wiedergeben.

Material und Methoden: Wir führten eine retrospektive Analyse der Literatur von 1957 bis 2012 mit Hilfe der MEDLINE-Datenbank durch. Die Suchbegriffe “osteoporosis” und “mast cells” bzw. “mastocytosis” ergaben 201 Treffer in englischer oder deutscher Sprache. Wir berücksichtigten Originalia und Fallstudien, die sich entweder mit Mastozytoseinduzierter Osteoporose oder der Bedeutung von Mastzellen bei Osteoporose auseinandersetzen.

Ergebnisse/Schlussfolgerung: Mastzellen scheinen eine gewichtige Rolle im Knochenstoffwechsel inne zu haben, Nebenprodukte der Mastzellen sind für vermehrten Knochenabbau verantwortlich. Mit dieser Literaturübersicht wollten wir daran erinnern, dass bei allen Patienten mit einer systemischen Mastozytose der Knochenstoffwechsel im Hinblick auf eine sekundäre Osteoporose untersucht werden sollte. Diese ist zwar selten, jedoch äußerst morbide.

Keywords

Mast cells - mastocytosis - osteoporosis

Schlüsselwörter

Mastzellen - Mastozytose - Osteoporose

Full Text

References

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