Late effects on haemostasis after haematopoietic stem cell transplantation

Summary

Allogeneic and autologous hematopoietic stem cell transplantations are important therapeutic options for patients with hematologic disorders. Hemostatic complications are frequent after hematopoietic stem cell transplantation with a considerable morbidity and mortality. The incidence of bleedings and thrombosis is highest in the first few weeks after transplantation, but may also occur later. However, beyond the first year of transplantation only limited data are available. In longterm survivors the risk for premature atherosclerosis increases over time after allogeneic hematopoietic stem cell transplantation and it is higher than in the age-adjusted general population and in recipients of autologous transplantation.

Zusammenfassung

Die allogene und autologe hämatopoietische Stammzelltransplantation ist eine wichtige therapeutische Option für Patienten mit hämatologischen Erkrankungen. Komplikationen der Hämostase sind relativ häufig und verursachen eine beträchtliche Morbidität und Mortalität. Blutungen und Thrombosen treten am häufigsten in den ersten Wochen nach der Transplantation auf, es sind jedoch auch Fälle im späteren Verlauf der Transplantation beschrieben. Über hämostatische Komplikationen, die nach einem Jahr auftreten, existieren nur noch sehr wenige Daten. Bei Langzeit-Überlebenden Patienten nach allogener Stammzelltransplantation nimmt im Laufe der Zeit das Risiko für zerebro- und kardiovaskuläre Ereignisse deutlich zu. Das Risiko ist höher als in der Alters-adaptierten Allgemeinbevölkerung und in Patienten nach auto loger Stammzelltransplantation.

Keywords

Haemostasis - venous thromboembolism - atherosclerosis - GvHD

Schlüsselwörter

Hämostase - venöse Thromboembolie - Atherosklerose - GvHD

• References

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