Effect of Low Compression on the Growth Plate. An Experimental Study in Sheep

E. Asimus; P. Collard; J. Sales de Gauzy; D. Mathon; R. Darmana; J.-Ph. Cahuzac; A. Autefage

doi:10.1055/s-0038-1632563

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 1997; 10(01): 16-22
DOI: 10.1055/s-0038-1632563

Original Research

Schattauer GmbH

Effect of Low Compression on the Growth Plate. An Experimental Study in Sheep

Authors

E. Asimus

¹From the Département des Sciences Cliniques, Ecole Nationale Vétérinaire, Toulouse, France

⁴Laboratoire du Tissu Osseux et des Pathologies Ostéoarticulaires, Université Paul Sabatier, Toulouse, France
P. Collard

¹From the Département des Sciences Cliniques, Ecole Nationale Vétérinaire, Toulouse, France

⁴Laboratoire du Tissu Osseux et des Pathologies Ostéoarticulaires, Université Paul Sabatier, Toulouse, France
J. Sales de Gauzy

²Service d’Orthopédie Pédiatrique, Hôpital Purpan, Toulouse, France

⁴Laboratoire du Tissu Osseux et des Pathologies Ostéoarticulaires, Université Paul Sabatier, Toulouse, France
D. Mathon

¹From the Département des Sciences Cliniques, Ecole Nationale Vétérinaire, Toulouse, France

⁴Laboratoire du Tissu Osseux et des Pathologies Ostéoarticulaires, Université Paul Sabatier, Toulouse, France
R. Darmana

³INSERM U 305, Toulouse, France

⁴Laboratoire du Tissu Osseux et des Pathologies Ostéoarticulaires, Université Paul Sabatier, Toulouse, France
J.-Ph. Cahuzac

²Service d’Orthopédie Pédiatrique, Hôpital Purpan, Toulouse, France

⁴Laboratoire du Tissu Osseux et des Pathologies Ostéoarticulaires, Université Paul Sabatier, Toulouse, France
A. Autefage

¹From the Département des Sciences Cliniques, Ecole Nationale Vétérinaire, Toulouse, France

⁴Laboratoire du Tissu Osseux et des Pathologies Ostéoarticulaires, Université Paul Sabatier, Toulouse, France

Abstract

Summary

This study was carried out to investigate the effect of compression on the growth plate. An external fixation device was applied across the distal radial physis in 24 eight-week-old lambs. Compression was applied continuously for seven weeks. A shamoperation was performed on the contralateral side. The animals were divided into two groups according to the rate of compression. In group #1, the mean pressure exerted by the compression device ranged from 0.03 ± 0.01 kg/cm² to 0.05 ± 0.01 kg/cm². In group #2, the mean pressure ranged from 0.08 ± 0.01 kg/cm² to 0.16 ± 0.01 kg/cm². The results obtained show that this pressure did not modify the longitudinal growth of the bone. A statistical difference was not noted between the operated side and the control side in any of the groups. We conclude that mild physeal compression (less than 0.16 kg/cm²) in the immature sheep would neither retard nor accelerate the growth of the distal radial epiphyseal plate.

An external fixation device was applied to the distal radial growth plate in immature sheep. Compression was performed continuously for seven weeks. The authors conclude that mild physeal compression (between 0.03 and 0.16 kg/cm²) neither diminished nor increased the growth.

Keywords

Growth plate - biomechanics - growth regulation - sheep

Full Text

References

REFERENCES
1 Alberty A, Peltonen J, Ritsilä V. Effects of distraction and compression on proliferation of growth plate chondrocytes. A study in rabbits. Acta Orthop Scand 1993; 64: 449-55.
2 Arkin AM, Katz JF. The effect of pressure on epiphyseal growth. J Bone Joint Surg 1956; 38 A: 1056-76.
3 Asimus E, Sales de Gauzy J, Mathon D. et al. Growth of the radius in sheep. An experimental model for monitoring activity of the growth plates. Rev Med Vet 1995; 146: 681-8.
4 Blount WP, Clarke GR. Control of bone growth by epiphyseal stapling. A preliminary report. J Bone Joint Surg 1949; 31 A: 464-78.
5 Blount WP, Zeier F. Control of bone length. J Am Med Assoc 1952; 148: 451-7.
6 Bonnel F, Dimeglio A, Baldet P, Rabischong P. Biomechanical activity of the growth plate. Anat Clin 1984; 6: 53-61.
7 Bonnel F, Peruchon E, Baldet P, Rabischong P. Comportement mécanique du cartilage de conjugaison. Etude expérimentale en compression. Rev Chir Orthop 1980; 66: 417-21.
8 Bonnel F, Peruchon E, Baldet P. et al. Effects of compression on growth plates in the rabbit. Acta Orthop Scand 1983; 54: 730-3.
9 Fjeld TO, Steen H. Correction of angular deformity by asymmetric physeal growth and bone remodeling. An experimental study in the canine radius. Vet Radiol 1986; 27: 58-64.
10 Fretz PB, Cymbaluk NF, Pharr JW. Quantitative analysis of long bone growth in the horse. Am J Vet Res 1984; 45: 1602-9.
11 Frost HM. Skeletal structural adaptations to mechanichal usage (SATMU): 3. The hyaline cartilage modeling problem. Anat Rec 1990; 226: 423-32.
12 Gelbke H. The influence of pressure and tension on growing bone in experiments with animals. J Bone Joint Surg 1951; 33 A: 947-54.
13 Gray ML, Pizzanelli AM, Lee RC. et al. Kinetics of the chondrocyte biosynthetic response to compressive load and release. Biochim Biophys Acta 1989; 991: 415-25.
14 Greco F, De Palma L, Specchia N, Mannarini M. Growth-plate cartilage metabolic response to mechanical stress. J Pediatr Orthop 1989; 9: 520-4.
15 Haas SL. Retardation of bone growth by a wire loop. J Bone Joint Surg 1945; 27: 25-36.
16 Haas SL. Mechanical retardation of bone growth. J Bone Joint Surg 1948; 30 A: 506-12.
17 Hall Craggs E. The effect of experimental epiphysiodesis on growth in length of the rabbit tibia. J Bone Joint Surg 1968; 50 B: 392-400.
18 Hansson LI, Wiberg G. Investigation of effect of metaphyseal traumatism on morphology of epiphyseal cartilage in rabbit. Acta Anat 1963; 52: 1-21.
19 Heikel HVA. Has epiphysiodesis in one end of a long bone a growth-stimulating effect on the other end ? An experimental study. Acta Orthop Scand 1961; 31: 18-24.
20 Karaharju EO, Ryöppy SA, Mäkinen RJ. Remodelling by asymmetrical epiphysial systemgrowth. An experimental study in dogs. J Bone Joint Surg 1976; 58 B: 122-6.
21 Klein-Nulend J, Veldhuijzen JP, Burger EH. Increased calcification of growth plate cartilage as a result of compressive force in vitro. Arthritis Rheum 1986; 28: 419-24.
22 Klein-Nulend J, Veldhuijzen JP, Van de Sradt RJ. et al. Influence of intermittent compressive force on proteoglycan content in calcifying growth plate cartilage in vitro. J Biol Chem 1987; 262: 490-5.
23 Peruchon E, Bonnel F, Baldet P, Rabischong P. Evaluation and control of growth activity of epiphyseal plate. Med Biol Eng Comput 1980; 18: 396-400.
24 Safran MR, Eeckardt JJ, Kabo JM, Oppenheim WL. Continued growth of the proximal part of the tibia after prosthetic reconstruction of the skeletally immature knee. J Bone Joint Surg 1992; 74 A: 1172-9.
25 Sijbrandij S. Inhibition of tibial growth by means of compression of its proximal epiphysial disc in the rabbit. Acta Anat 1963; 55: 278-85.
26 Strobino LJ, French GO, Colonna PC. The effect of increasing tensions on the growth of epiphyseal bone. Surg Gyne Obstet 1952; 95: 694-700.
27 Trueta J, Trias A. The vascular contribution to osteogenesis: IV. The effect of pressure upon the epiphysial cartilage of the rabbit. J Bone Joint Surg 1961; 43 B: 800-13.
28 Wilson-Macdonald J, Houghton GR, Bradley J, Morscher E. The relationship between periosteal division and compression or distraction of the growth plate. An experimental study in the rabbit. J Bone Joint Surg 1990; 72 B: 303-8.
29 Zionts LE, Macewen GD. Spontaneous improvement of post-traumatic tibia valga. J Bone Joint Surg 1986; 68 A: 680-7.