Open Access
CC BY 4.0 · J Neurol Surg B Skull Base 2018; 79(S 01): S1-S188
DOI: 10.1055/s-0038-1633785
Poster Presentations

Surgical Management and Outcomes of Intracranial Chondromas: A Single Institute Experience

Authors

  • Da Li

    1   Beijing Tiantan Hospital, Capital Medical University, Beijing, Republic of China

  • Jian-Cong Weng

    1   Beijing Tiantan Hospital, Capital Medical University, Beijing, Republic of China

  • Zhen Wu

    1   Beijing Tiantan Hospital, Capital Medical University, Beijing, Republic of China

  • Li-Wei Zhang

    1   Beijing Tiantan Hospital, Capital Medical University, Beijing, Republic of China

  • Jun-Ting Zhang

    1   Beijing Tiantan Hospital, Capital Medical University, Beijing, Republic of China
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Objective Management of intracranial chondromas (ICDs) is difficult. This study aims to propose a tailored management strategy based on our management of ICDs.

Methods A retrospective review was performed in 66 patients who received surgical operations at our institute. Clinical charts and radiographs were reviewed, follow-up was performed, and adverse factors for progression-free survival (PFS) and overall survival (OS) were evaluated.

Results The pre- and postoperative KPSs were 81.8 and 72.3, respectively. The mean tumor size was 3.5 cm. Gross total resection was achieved in 15 patients (22.7%). Six patients (10.3%) received postoperative radiation. After a mean follow-up duration of 85.5 months, recurrence occurred to 15 patients (28.8%) with surgery alone, and no recurrence was observed in patients receiving postoperative radiotherapy. Six patients (10.3%) died due to tumor progression. The risk factors affecting the PFS included the age of <33 years (HR: 6.876; 95% CI: 1.599−29.560; p = 0.010), tumor size ≥3.1 cm (HR: 6.138; 95% CI: 1.259−29.926; p = 0.025), tumor with evident atypia/mitotic activity (HR: 4.672; 95% CI: 1.352−16.152; p = 0.015), and partial resection (PR) (HR: 12.841; 95% CI: 3.004−54.896; p < 0.001). In all patients, the PFS rate was 75% at 5 years and 64% at 10 years; in addition, the OS rate was 93% at 5 years and 83% at 10 years.

Conclusion The therapeutic strategy for ICDs should be individualized and should consider preoperative variables. GTR was attempted if the tumors were resectable; otherwise, subtotal resection was alternative. In patients with both PR and evident atypia/mitotic activity, consultation with oncologist for radiotherapy was recommended.


No conflict of interest has been declared by the author(s).

Publication History

Publication Date:
02 February 2018 (online)

© 2018. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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