Abstract
         
         
            Background Secure clinical messaging and document exchange utilizing the Direct Protocol (Direct
            interoperability) has been widely implemented in health information technology (HIT)
            applications including electronic health records (EHRs) and by health care providers
            and organizations in the United States. While Direct interoperability has allowed
            clinicians and institutions to satisfy regulatory requirements and has facilitated
            communication and electronic data exchange as patients transition across care environments,
            feature and function enhancements to HIT implementations of the Direct Protocol are
            required to optimize the use of this technology.
         
         
            Objective To describe and address this gap, we developed a prioritized list of recommended
            features and functions desired by clinicians to utilize Direct interoperability for
            improved quality, safety, and efficiency of patient care. This consensus statement
            is intended to inform policy makers and HIT vendors to encourage further development
            and implementation of system capabilities to improve clinical care.
         
         
            Methods An ad hoc group of interested clinicians came together under the auspices of DirectTrust
            to address challenges of usability and create a consensus recommendation. This group
            drafted a list of desired features and functions that was published online. Comments
            were solicited from interested parties including clinicians, EHR and other HIT vendors,
            and trade organizations. Resultant comments were collected, reviewed by the authors,
            and incorporated into the final recommendations.
         
         
            Results This consensus statement contains a list of 57 clinically desirable features and
            functions categorized and prioritized for support by policy makers, development by
            HIT vendors, and implementation and use by clinicians.
         
         
            Conclusion Fully featured, standardized implementation of Direct interoperability will allow
            clinicians to utilize Direct messaging more effectively as a component of HIT and
            EHR interoperability to improve care transitions and coordination.
         
      
         
         Keywords
         provider–provider communications - 
         interfaces and usability - 
         care transition - 
         health information interoperability - 
         health information exchange - 
         user–computer interface - 
         continuity of care document
         
 
      
      Background and Significance
      
      The Direct Standard for secure and interoperable electronic transport of clinically
         relevant messages and attachments was developed by the Office of the National Coordinator
         for Healthcare Information Technology, an agency of the United States (U.S.) Department
         of Health and Human Services, in a public–private partnership during 2010 and 2011
         known as the Direct Project.[1] When used by clinicians, hospitals, or others to share clinical content across organizational
         and health information technology (HIT) vendor boundaries, the combination of that
         content and the use of the Direct Standard is known as “Direct interoperability,”
         “Direct messaging,” “Direct exchange,” or sometimes simply “Direct.” Direct interoperability
         is a key component of a multiyear U.S. effort to reward clinicians and hospitals for
         the “meaningful use” of EHRs and other HIT under the statutory mandates of the law
         known as the Health Information Technology for Economic and Clinical Health (HITECH)
         Act,[2] enacted as part of the American Recovery and Reinvestment Act of 2009. Under HITECH,
         eligible professionals and hospitals are required to meet certain criteria for electronic
         exchange of health information to receive incentive payments and to avoid payment
         penalties. For example, if a primary care physician refers a patient to a specialist
         and sends the patient's Clinical Summary using Direct interoperability, they meet
         one of the meaningful use criteria related to transitions of care.
      
      Since its introduction in 2011, use of Direct interoperability to send, or “push”
         health information from one provider or organization to another has grown rapidly
         and use cases have expanded.[3]
         [4]
         [5] As of late 2017, there were over 100,000 health care organizations in the United
         States with at least one Direct account, and over 1.6 million clinicians and staff
         members at these hospitals, medical offices, clinics, long-term care facilities, and
         other institutions who can send and receive messages and attachments via Direct interoperability.
         Over 350 EHR and personal health record (PHR) products are capable of Direct interoperability.
         While care coordination and transitions of care remain among the most common use cases,
         secure transport of laboratory and other test results,[6]
         [7] sharing of claims attachments, and reporting from EHRs to disease and population
         management databases and registries are among the many other uses to which Direct
         interoperability is now being put, often replacing fax, electronic fax, mail, and
         courier as a preferred transport mechanism.
      
      Secure, interoperable sharing of patients' clinical information improves operational
         efficiency and is critically important to patients, clinicians, and care teams involved
         in patient care transitions and coordination. This is particularly valuable where
         patients are engaged with multiple clinicians from disparate organizations, who utilize
         diverse EHRs and other HIT applications. Although most HIT-enabled organizations in
         the United States have installed systems with Direct interoperability capabilities,
         after years of experience, this valuable functionality remains poorly understood and
         underutilized by many clinicians and hospitals. The robust EHR features and functionalities
         needed for the optimal use of Direct interoperability remain undeveloped by some HIT
         vendors, unimplemented by health care organizations, or unused by clinicians.[8]
         [9]
         [10] To date, there have been no peer-reviewed journal articles examining the use or usability
         of Direct interoperability.
      
         
      
      Objective
      
      To address the inadequacies of existing clinical messaging functions in HIT systems,
         in November 2016 DirectTrust[11] convened a group of interested clinicians with experience in Direct interoperability
         using diverse EHRs and other HIT applications. This group created a list of prioritized
         feature and function recommendations intended for the broad EHR and HIT vendor community
         to enhance the usability of Direct interoperability.
      
         
      
      Methods
      
      A draft list of 51 recommended features and functions was published online on February
         1, 2017 with an invitation for public comment.[12] The document was broadly disseminated through HIT media, listserves, and professional
         organizations. Comments were accepted via email through April, 2017. Additional input
         was collected from vendors and other stakeholders at a Direct Exchange Workshop held
         by the Office of the National Coordinator for Health Information Technology in Washington,
         D.C., on June 9, 2017. The workgroup reviewed and developed responses to all written
         comments during a dozen open online meetings and made multiple changes to its original
         recommendations.
      
      The workgroup categorized recommendations by use case, i.e., transitions of care,
         clinical messaging, and administrative functions. Recommendations were further segmented,
         as appropriate, into “outbound” and “inbound” message functions to offer additional
         organization and clarity. The clinical rationale for each recommendation was also
         documented. A priority was assigned to each recommendation with “1” as the highest
         need, “2” as highly desirable, and “3” indicating anticipated future needs. Finally,
         each priority was given a recommended timing, with the highest priority items recommended
         for inclusion in the current or next version of HIT products, priority 2 items within
         1 to 2 years, and priority 3 thereafter.
      
         
      
      Results
      
      One hundred fifty-one comments were received from organizations and individuals representing
         10 HIT vendors and 13 U.S. health care provider and payer organizations. One hundred
         sixteen (77%) of the comments were from HIT vendors. The workgroup received extensive
         feedback focusing on the need to improve the usability of Direct interoperability,
         the value of clinical messaging, the critical need for users to be able to trust the
         information received, and the technical feasibility and challenges of implementing
         the recommendations provided. The comments included broad support for building upon
         the success of Direct interoperability as currently implemented by HIT vendors. The
         initial recommendations and the feedback resulted in the 57 final recommendations
         detailed in [Tables 1]
         [2]
         [3].
      
      
         
            Table 1 
               Recommendations for transitions of care
               
            
               
               
                  
                  | 
                        Priority 1
                         | Required/Urgent/Now/Current-next version | 
               
               
                  
                  | 
                        Priority 2
                         | Highly desired/Future priority/1–2 y/Subsequent version | 
               
               
                  
                  | 
                        Priority 3
                         | Advanced/Future development | 
               
               
                  
                  | 
                        Transitions of care
                         | 
               
               
                  
                  | 
                        Feature/Function
                         | 
                        Recommendation
                         | 
                        Rationale
                         | 
                        Priority
                         | 
               
               
                  
                  | Outbound message functions | 
               
               
                  
                  | TO1: Real-time message delivery | Direct interoperability messages are sent in “real time” and are never “batched” for
                        timed sends | The sending of messages in real time, following a patient's transition of care, supports
                        end users' ability to utilize information for patient care immediately. Clinicians,
                        who have successfully used Direct, report that receiving the Direct message in “real-time”
                        as opposed to batch processes allows the receiver to initiate appropriate patient
                        outreach and follow up immediately preventing patient adverse events. It also allows
                        patient care and transitional care management to be provided more efficiently | 1 | 
               
               
                  
                  | TO2: Direct messages automatically triggered by specific events | HIT systems can automatically send Direct messages based on specific triggers (e.g.,
                        discharge or referral orders) | Automated real-time sending of Direct messages ensures that the patient's treating
                        clinicians are aware of care transitions and are provided with the most current and
                        up to date information. Timely receipt of messages facilitates information reconciliation
                        in the recipient systems, helps to prevent unnecessary duplicate testing, and reduces
                        adverse events. For example, an acute care system can be configured so that when a
                        patient discharge order is entered this triggers the automated sending of a Consolidated
                        Clinical Document Architecture (C-CDA) document, or a template of combined C-CDA document
                        sections to the patient's Primary Care Provider (PCP) and/or ambulatory provider of
                        record in the system, if a Direct address is available for that clinician. The ambulatory
                        systems can be configured to send a Direct Message to a specialist triggered by a
                        PCP's referral order. Similarly, consultants' EHR systems can be configured to send
                        a Direct Message to the referring provider prompted by a referred patient being seen
                        and/or the completion of the consultation note | 1 | 
               
               
                  
                  | TO3: Automatically send Direct message(s) to provider(s) of record with Direct addresses
                        in the sending system | Once a triggering event occurs, the sending system is able to automatically send a
                        message to: – the PCP of record – the referring physician – all providers identified as members of the patient's care team, and/or – another identified provider, given that the(se) provider(s) have Direct Addresses | This recommendation ensures continuity of care with the identified members of the
                        patient's care team and prevents the blocking of information flow to the patient's
                        providers across organizational boundaries | 1 | 
               
               
                  
                  | TO4: Include patient-specific attachments | The sending facility is able to configure a Direct “template” (see also TO7) that
                        includes automatically attached document types and/or sections from the sending HIT
                        system based on the specific clinical scenario. Attachments can include structured
                        data (e.g., C-CDA, or a template with a combination of C-CDA document types or sections,
                        spreadsheets); unstructured data (e.g., Word, PDF, or plain text files) and image
                        files (e.g., JPG and GIF). In addition, providers can attach documents “on the fly”
                        as needed | Direct has been demonstrated to provide a critical capability for information sharing
                        in support of patient care, which essentially virtualizes the EHR across disparate
                        HIT systems and health care organizations to support care team access to critical
                        patient information. Direct messages should support the inclusion of all clinically
                        relevant document types in support of best practice and efficient care as patients
                        transition across their medical neighborhoods. The inclusion of a variety of document
                        types also prevents duplicate testing or gaps in clinical information required for
                        patient care | 1 | 
               
               
                  
                  | TO5: Use HIT industry-wide standardized discrete data terminology for problem, medication,
                        allergy, immunization data in Direct documents | Vendors use all existing recognized standard vocabularies to promote information sharing
                        across all HIT systems and the ability of the recipient system to readily consume
                        and reconcile discrete information Data reconciliation by the sending provider preceding and by the recipient provider
                        following all care transitions should include all data for which there are discrete
                        vocabularies including active problems, allergies, medications, and historical immunizations
                        (PAMI data) Specific vocabularies (e.g., SNOMED, ICD10, RxNorm, and CVX) should be used to encode
                        discrete PAMI data as applicable in all C-CDA and other documents sent via Direct | Direct interoperability supports the sharing of patient data using standardized data
                        vocabularies across all EHR vendors. Standardized use and transmission of discrete
                        data would allow for exceptional end user functionality creating care and documentation
                        efficiencies and preventing life-threatening transcription errors. These efficiencies
                        would further promote the desirability and use of Direct messaging and facilitate
                        medical information reconciliation across the patient's care team. Exchange of discrete
                        data via Direct, with appropriate pre- and posttransition of care clinician data reconciliation,
                        can save clinicians documentation time and prevent potentially life-threatening transcription
                        errors and patient adverse events | 1 | 
               
               
                  
                  | TO6: Automated outgoing messages include the “trigger” for sending the message in the message
                        metadata | Automatic outgoing messages' metadata include the “trigger” for sending the automated
                        message (e.g., hospital discharge or specialty referral) | Including information regarding the message trigger in the metadata sent with a Direct
                        message allows the recipient systems to automatically or manually route and/or prioritize
                        messages for specific organizational role-based workflows | 2 | 
               
               
                  
                  | TO7: Ability to customize C-CDA templates | Sending organization are able to configure templates for specific clinical circumstances
                        such as discharge, referral, specific conditions/diagnoses, or encounter types. Templates
                        are configurable at the provider or organization level Templates can be a single or a combination of C-CDA document types or C-CDA document
                        type sections Examples include:  • A “Discharge Template” could be configured to include a brief clinical summary,
                        a reconciled discharge problem list, medications, allergies, immunizations, procedures,
                        first and last instance of any laboratory or test results, imaging studies, operative
                        notes, vital signs, discharge instructions, etc.  • A “Cardiology Referral Template” could be configured to include the patient's last
                        clinic note, specific laboratories and studies relevant to cardiology, the patient's
                        active problems, medications, allergies, immunizations, family, medical, surgical,
                        and social histories, urgency of request, and request for a specific cardiologist Templates could be configured either at the provider or organization level. With the
                        organization having the ability to determine the level (e.g., only allowing templates
                        to be configured at the organizational level to support organizational standardization).
                        Appropriate templates could be generated automatically based the message trigger event
                        (e.g., Cardiology referral or discharge order) the system will automatically assemble
                        the appropriate template. | Template customization allows the organization to preconfigure Direct messages to
                        include the appropriate information for the next provider caring for the patient.
                        As a result, messages will include the right information and the right amount of information
                        and will save the sending clinician time by avoiding the need to collate information
                        manually for every outgoing Direct message. Having the right amount and most current
                        patient information may also cause the recipient to attribute greater value to incoming
                        messages preventing information overload and inaccuracies resulting from outdated
                        information | 2 | 
               
               
                  
                  | TO8: System alert if automated message cannot be sent when the send trigger is invoked | The system can issue an alert if the sending of an automated message fails. For example,
                        a discharge order may trigger an automated discharge message, but the sending of the
                        message fails because the system lacks a PCP of record or the PCP of record does not
                        have a Direct address. In this case, the system will alert the provider, or his or
                        her delegate, whose action (e.g., discharge order) precipitated the trigger event | This system alert will ensure that the failure of a Direct message to leave the initiating
                        system will result in an alert to the clinician, or his or her designee, who can then
                        initiate an alternative information sharing process (e.g., fax, postal mail, telephone
                        call, etc.) As health care providers and organizations implement new automated electronic
                        messaging systems, older communications processes may be left in place leading to
                        redundant communication via multiple channels with resultant information overload
                        and decreased attention to information received. The ability to know when an automated
                        Direct message cannot be sent supports the decommissioning of alternate automated
                        messaging, such as faxing/mailing result reports or discharge summaries, allowing
                        these methodologies to be used only in circumstances where a Direct message cannot
                        be sent | 2 | 
               
               
                  
                  | TO9: Use HIT industry-wide standardized discrete data terminology for additional data types
                        including procedures and laboratory results | Vendors will use recognized standardized vocabularies to exchange discrete data beyond
                        PAMI data types (e.g., LOINC codes for laboratory results and CPT codes for procedures)
                        to allow information sharing, consumption, and reconciliation across HIT systems | This recommendation promotes the exchange and recipient system consumption of discrete
                        patient data in support of data reconciliation, care efficiency, population health
                        management, and reduces medical errors and duplicate testing | 2 | 
               
               
                  
                  | TO10: Automatically send Direct message to the patient | According to the health care organization's protocols and policies and the patient's
                        wishes, the system may automatically send relevant Direct messages to the patient
                        if the patient has a Direct address | This recommendation allows patients to receive their health information without the
                        need to visit multiple health care organization linked portals | 3 | 
               
               
                  
                  | TO11: Medical societies shall create condition-specific templates for referrals | We recommend that specialty-specific medical societies create and share with the health
                        care community diagnosis and condition-specific templates that include the clinical
                        information and data elements such as tests and study results to be sent when a patient
                        is being referred to a specialist, or health care facility with that specific diagnosis
                        or condition | Diagnosis/condition-specific templates specified and supported by medical societies
                        will assure that specialists receive the appropriate information from referring providers
                        in a standardized fashion and will prevent information overload by recipient clinicians,
                        improving the efficiency of care transitions and coordination | 3 | 
               
               
                  
                  | Inbound message functions | 
               
               
                  
                  | TI1: Receive, store and display message attachments in the recipient HIT system | In addition to the C-CDA, or a template of combined C-CDA documents and/or document
                        sections, HIT systems support receipt, storage, and display of a wide variety of attachment
                        types including:  • structured data (e.g., C-CDA, spreadsheets)  • unstructured data (e.g., Word, PDF)  • plain text files  • image files (e.g., JPG and GIF) | Medical information exists in a variety of formats (e.g., structured data, unstructured
                        data, images, and PDF files). To support efficient care, avoid duplication of tests
                        and procedures, and reduce information gaps, Direct messages should allow the inclusion
                        of all clinically relevant document types to support the transition of patients across
                        their medical neighborhoods. This recommendation discourages vendors from removing
                        valuable information by stripping attachments from messages | 1 | 
               
               
                  
                  | TI2: Automated patient identification | All HIT systems automatically match incoming Direct messages with existing patients
                        in the recipient system. Without a unique patient identifier, systems use their existing
                        patient matching algorithms. For new patients or patients, who cannot be automatically
                        matched (e.g., new referral to a specialist, or patient demographic information that
                        could match to more than one existing patient record); the receiving system will route
                        the message to a work queue for patient registration and/or manual matching. Incoming
                        data for matched patients will be stored and available to the designated recipient
                        and his or her delegate(s) | Lack of an automated patient identification/matching service degrades Direct interoperability
                        to the level of an EHR integrated fax server. Manual patient matching delays Direct
                        messages from reaching the appropriate user, putting patients at increased risk for
                        adverse events in the context of care transitions Depending on HIT functionality, staffing models and volume of Direct messages, delays
                        from manual matching may exceed 24 hours, putting patients at risk for adverse events.
                        Patient matching must be automated to prevent impeding data flowing to the intended
                        recipients, to support information sharing for patient care, and to reduce the risk
                        of life-threatening complications including adverse drug events As Direct is adopted for all transitions of care (TOC) and clinical messaging, the
                        anticipated volume of incoming messages would require additional staff resources if
                        incoming message patient matching were conducted manually | 1 | 
               
               
                  
                  | TI3: Reconciliation of active medications | The system supports the reconciliation of active medications Following any patient
                        care transition, the C-CDA or a template with a combination of C-CDA document types
                        or sections includes a list of active medications:  • For new patients, the recipient, or his or her delegate(s), can use the medication
                        list to integrate all medications and associated administration instructions (Sigs)
                        into the receiving system as discrete, actionable data  • For established patients, the recipient, or his or her delegate(s), can directly
                        review and compare the received medication list and sig with the medication list and
                        sig in his/her native HIT system. The provider can then use his/her judgment to perform
                        medication reconciliation by: discontinuing medications, adding medications, or changing
                        the dose of medications in his/her system based on medication changes made by the
                        sending provider. As the receiving user accepts new medications information from a
                        received C-CDA document into the receiving system, the medication information is transferred
                        as discrete data with the sig  • Medications that the provider sees on the C-CDA, but does not want the patient
                        to continue would not be integrated into his or her updated medication list and could
                        trigger a discontinuation discussion with the patient | Pre- and post-transition of care medication reconciliation using discrete data received
                        via Direct can ensure that recipient clinicians have the most accurate and current
                        information available for information reconciliation and system data consumption thereby
                        enhancing care efficiency, saving clinicians' time, resulting in reduced errors, saved
                        patient lives, and decreased costs | 1 | 
               
               
                  
                  | TI4: Reconciliation of active problems | The system supports the reconciliation of active problems Following any patient care transition, the provided C-CDA or a template with a combination
                        of C-CDA document types, or sections includes an encoded list (e.g., utilizing ICD10
                        and/or SNOMED codes) of active medical problems/conditions:  • For new patients, the recipient user, or his or her delegate(s) should be able
                        to integrate this list directly into his/her HIT system as discrete, actionable data  • For established patients, the recipient provider should be able to compare onscreen
                        the problem list in his/her native system and with the problem list received in the
                        C-CDA, allowing the provider to perform problem list reconciliation by discontinuing
                        problems that have been superseded or are inactive or adding new problems to his/her
                        EHR that are warranted  • Problems in the C-CDA that the providers does not considers active would not be
                        transferred to the new list and may generate follow-up discussion with the patient | Reconciliation of patient problem lists pre- and post-transitions of care using discrete
                        data exchanged via Direct can improve care efficiency and save clinicians time resulting
                        in reduced errors and decreased costs | 1 | 
               
               
                  
                  | TI5: Reconciliation of allergies | The system supports the reconciliation of patient allergies Following any patient care transition, the received C-CDA or a template with a combination
                        of C-CDA document types or sections includes an encoded list of the patient's current/active
                        allergies:  • For new patients, the recipient provider, or his or her delegate(s) should be able
                        to integrate this list directly into his/her HIT system as discrete, actionable data  • For established patients, the recipient provider should be able to compare onscreen
                        the allergies list in his/her local system and the allergies list received in the
                        C-CDA document. The provider can them perform allergy reconciliation | Reconciliation of patient allergies pre- and post-transition of care using discrete
                        data exchanged via Direct can improve care efficiency and save clinicians time resulting
                        in reduced errors and decreased costs | 1 | 
               
               
                  
                  | TI6: Reconciliation of immunizations | The system supports the reconciliation of patient immunization histories Following any patient care transition, the provided C-CDA or a template with a combination
                        of C-CDA document types or sections includes an encoded list (e.g., utilizing CXV
                        codes) of the patient's current/active immunizations:  • For new patients, the recipient provider, or his or her delegate(s) should be able
                        to integrate this list directly into his/her EHR system as discrete, actionable data  • For established patients, the recipient provider should be able to compare onscreen
                        the immunization list in his/her local EHR and the immunization list received in the
                        C-CDA. The provider can them perform immunization reconciliation | Reconciliation of patient immunization histories pre- and post-transition of care
                        using discrete data exchanged via Direct can improve care efficiency and save clinicians
                        time resulting in reduced errors and decreased costs | 1 | 
               
               
                  
                  | TI7: Reconciliation of procedures | The system supports the reconciliation of patient procedure histories Following any patient care transition, the provided C-CDA or a template with a combination
                        of C-CDA document types or sections includes an encoded list (e.g., utilizing CPT
                        or SNOMED codes) of the patient's past procedures and operations:  • For new patients, the recipient provider (or his or her delegate) should be able
                        to integrate this list directly into his/her EHR system as discrete, actionable data  • For established patients, the recipient provider should be able to compare onscreen
                        the procedures and operations (CPT Codes) list in his/her local EHR and the procedures
                        and operations (CPT Codes) list received in the C-CDA. The provider can them perform
                        procedure reconciliation | Reconciliation of patient procedure and surgical histories pre- and post-transition
                        of care using discrete data exchanged via Direct can improve care efficiency and save
                        clinicians time resulting in reduced errors and decreased costs | 2 | 
               
               
                  
                  | TI8: Reconciliation of test results | Following any patient care transition, the provided C-CDA, or a template with a combination
                        of C-CDA document types and sections, includes an encoded list of tests or studies
                        performed and their results (e.g., utilizing LOINC codes for laboratory test result
                        components and SNOMED codes for other result values):  • For new and established patients, the recipient user, or his or her delegate(s)
                        should be able to integrate, at their discretion, all or some of these tests and studies
                        directly into his/her HIT system as discrete, actionable data including but not limited
                        to laboratory, radiology, gastroenterology, neurology, cardiovascular, and pulmonary
                        testing. All of the native system functionalities (e.g., being able to compare results,
                        create flow sheets, and utilize graphing functions) shall be applicable to the data
                        received | Receipt and incorporation of historical laboratory and other test results using discrete
                        data exchanged via Direct can reduce duplicative testing, improve patient safety and
                        care efficiency and save clinicians' time resulting in reduced errors, decreased costs,
                        and improved clinical outcomes. | 2 | 
               
               
                  
                  | TI9: Other discrete data exchange and reconciliation | As standardized vocabulary use increases in HIT systems, additional standardized data
                        elements will be included in Direct messages and enabled for reconciliation across
                        systems. Data may include social, family, and medical histories, genomic data, patient-generated
                        health data, patient satisfaction, social determinates of health, medical device data,
                        patient care team members, etc. | Direct exchange and reconciliation of additional data types using discrete data can
                        reduce duplicative testing, improve patient safety and care efficiency, and save clinicians'
                        time resulting in reduced errors, decreased costs, and improved clinical outcomes | 3 | 
               
               
                  
                  | TI10: Recipient configuration of the information viewed from the incoming message (C-CDA) | Recipient systems are able to configure the display of information received with an
                        incoming message Configuration may be specified at the organization or user level For example, the view of a discharge summary that includes all of the information
                        from a hospitalization (every vital sign, laboratory test and study, input and output,
                        etc.) deemed unnecessary by the recipient provider can be configured so that, for
                        example, only the first and last vital sign and first and last instance of any laboratory
                        test or study are visible. Configurability assures that the information that is displayed
                        is limited to the information that the recipient wants to see and is presented to
                        the user in a consistent manner. The system will also allow the recipient to view
                        the information that was received but not displayed by default (i.e., drill down) | Allowing users to determine which information is most relevant information and to
                        configure his/her view of the received information facilitates efficient review of
                        critical information for patient care and enhances the adoption of this technology.
                        The ability for the recipient user to drill down to other information, if needed,
                        allows the recipient user to access all information if the preconfigured view does
                        not include information the user requires in a specific instance of care | 3 | 
               
               
                  
                  | TI11: Recipient system identifies new or revised data | For existing patients, the recipient system will identify all discrete information
                        in the received document that is new or changed compared with the existing discrete
                        information in the receiving system | Identifying new or modified data automatically, enables clinicians to focus their
                        attention on relevant new and revised data resulting in more efficient patient care
                        following a patient's care transition. This also facilitates ease of data reconciliation
                        and prevention of duplicate testing and adverse patient events, thereby reducing health
                        care costs | 3 | 
               
         
         
         
         Abbreviations: CPT, Current Procedural Terminology; EHR, electronic health records;
            HIT, health information technology; ICD10, International Classification of Diseases,
            Tenth Revision; LOINC, Logical Observation Identifiers Names and Codes; PAMI data,
            problems, allergies, medications, and immunizations data; SNOMED, Systematized Nomenclature
            of Medicine.
         
          
      
      
      
      
         
            Table 2 
               Recommendations for clinical messaging
               
            
               
               
                  
                  | 
                        Priority 1
                         | Required/Urgent/Now/Current-next version | 
               
               
                  
                  | 
                        Priority 2
                         | Highly desired/Future priority/1–2 y/Subsequent version | 
               
               
                  
                  | 
                        Priority 3
                         | Advanced/Future development | 
               
               
                  
                  | 
                        Clinical messaging
                         | 
               
               
                  
                  | 
                        Feature/Function
                         | 
                        Recommendation
                         | 
                        Rationale
                         | 
                        Priority
                         | 
               
               
                  
                  | Outbound message functions | 
               
               
                  
                  | CO1: Compose message | Sending user may create a patient-specific Direct message to send to a Direct recipient | Composing messages supports standard and familiar email-like functionality, allows
                        patient-specific information to be securely transferred from one HIT system to another
                        to support patient-specific care coordination | 1 | 
               
               
                  
                  | CO2: Addresses message to a Direct recipient | Sending user may select a new recipient by selecting the recipient's name from a prepopulated
                        list or by entering his/her Direct address in the recipient field | This facilitates the end user's ability to send a Direct message to a Direct recipient
                        of their choosing, whether or not the system is preconfigured with the recipient's
                        Direct address | 1 | 
               
               
                  
                  | CO3: Add attachments to patient-specific messages | Sending user may add one or more patient-specific attachments, to the outgoing patient-specific
                        message. Attachments will consistently be delivered with the message Supported document types include structured data (e.g., any structured C-CDA document
                        type or a template with a combination of C-CDA sections, document types such as spreadsheets
                        (e.g., Excel), unstructured data (e.g., Word, PDF, and plain text files), and image
                        files (e.g., JPG and GIF) | The ability to add attachments allows robust communication in support of patient care
                        since it enables users to attach a variety of document types including scanned paper-based
                        documents and clinical images | 1 | 
               
               
                  
                  | CO4: Forward messages within recipient organization | Recipient user can forward received messages and/or any associated attachments to
                        one or more other recipients within their organization as needed to support clinical
                        care | Forwarding messages supports team-based patient care by allowing appropriate sharing
                        of information | 1 | 
               
               
                  
                  | CO5: Reply | Recipient user can reply to the sender of a Direct message, maintaining continuity
                        between the original received message and the reply | Reply functionality enables efficient Direct communication and maintains the continuity
                        of message strings | 1 | 
               
               
                  
                  | CO6: Message Context | Sending and recipient users can identify the message Context. Context is established
                        based on a standard list of Context types. All automated Direct message templates
                        (see TO7) may have a preconfigured Context as part of the template specification.
                        Context may be determined from ADT fields, the document type, or other sources | A message Context that is visible and identifiable to the recipient helps to expedite
                        patient care. It also allows messages of specific Context types to be routed to the
                        appropriate user within the recipient's system | 1 | 
               
               
                  
                  | CO7: Message Subject | Sending user can enter a message Subject as free text or selected from a predetermined
                        list of commonly used Subjects. The Subject specified by the sending user is displayed
                        to the receiving user(s) | This recommendation implements a standard and familiar email function and supports
                        efficient and/or automated sorting, routing, and management of messages based on the
                        Subject | 2 | 
               
               
                  
                  | CO8: User-specific list of “favorite” Direct Recipients | Users can configure and maintain a list of their personal “favorite” or frequently
                        used Direct recipients | A favorites list facilitates the end user's ability to efficiently send a Direct message
                        to a Direct recipient by selecting the recipient from the sender's favorites list | 2 | 
               
               
                  
                  | CO9: Multiple recipients | Users can send messages to multiple recipients simultaneously utilizing standard fields
                        of “To” and “CC” (carbon copy). There should be no “BCC” (blind carbon copy) functionality | The ability to send a message simultaneously to multiple recipients supports the inclusion
                        of additional relevant members of the care team into the TOC process. BCC functionality
                        is not appropriate for clinical messaging which may become a part of a patient's permanent
                        legal medical record | 2 | 
               
               
                  
                  | CO10: Patient-specific distribution lists | Users can create, maintain, and utilize patient-specific message recipient distribution
                        lists and have the ability to easily select some or all members of a patient's lit
                        to receive a message | Patient-specific distribution lists allow for the maintenance of a list of a patient's
                        care team members. Such lists support the efficient routing of a single message to
                        more than one member of the patient's care team | 2 | 
               
               
                  
                  | CO11: Send on behalf of | Sending user can compose and send a message on behalf of another individual with proper
                        authorization and attribution | This recommendation improves efficiency of communication for clinicians working within
                        a care team | 2 | 
               
               
                  
                  | CO12: Message delivery notification | Sending user is notified if the message cannot be delivered to the intended recipient
                        or their designee. The system can be configured to notify the sending user of both
                        successful and failed delivery if the end user so desires. The failure notification
                        message includes a reason for failure if known | The sending user must have confidence that a sent message was delivered to the intended
                        recipient or their designee Unless users can confidently know that a message was delivered,
                        or was undeliverable, transition from existing messaging functionalities, such as
                        fax and postal mail, to Direct will be delayed A failed delivery notification may
                        be used by the sending organization as a trigger to initiate an investigation or troubleshooting
                        or to reconfigure their system or workflows to facilitate future communications | 2 | 
               
               
                  
                  | CO13: Message Priority | Sending user can optionally indicate the Priority or level of importance of the message.
                        (i.e., urgent, standard, nonurgent). The specified Priority will be displayed to the
                        recipient. Organizations can configure that messages without a Priority indication
                        are sent as “standard” | The sending user will be able to indicate message urgency to recipient allowing the
                        recipient to prioritize which messages to attend to in what order. The level of importance
                        can also be used to trigger additional functionality such as sorting or routing of
                        messages | 2 | 
               
               
                  
                  | CO14: Reply all | Recipient user can reply to the sender of a Direct message and to one or more additional
                        recipients of the original message | This replicates standard email functionality and facilitates inclusion of team members
                        on a response to a received message. This functionality is particularly valuable when
                        a patient is cared for by team members at multiple organizations | 2 | 
               
               
                  
                  | CO15: Read receipt | Sending user can be notified once a sent message has been opened by the intended recipient
                        or their designee. The sending system can be configured to turn on/off read receipt
                        at the organization or individual level. System configuration can set up the appropriate
                        individual(s) or message pool(s) to receive read-receipt messages and the timeframe
                        to receive an “unopened message” notification. The sending organization can also configure
                        specific messages types that require read-receipt notification and/or allow the sender
                        to activate the read-receipt feature on the fly when sending a message. The read-receipt
                        message will also include the name and role of the individual in the recipient organization,
                        who opened the message | Read-receipt functionality ensures that the sender, or his/her designee, is informed
                        that a sent message has failed to reach a recipient, or if someone in the recipient
                        organization has actually opened the message in the period defined by the sender.
                        This feature assures timely follow-up and reduces the risk for clinical communications
                        and/or tasks to remain incomplete | 3 | 
               
               
                  
                  | CO16: Configurable message receipt notification | Sending user can configure his/her message receipt notification to “yes” or “no” manually
                        or automatically based on the Priority of the outgoing message, and can configure
                        the timeframe for the notification. For example, urgent messages can be configured
                        to always trigger a failed message receipt within 8 hours of sending | Sending user will be aware of important message send failures alerting them of the
                        need to use alternative methods of communication, particularly in the event of urgent
                        message send failures | 3 | 
               
               
                  
                  | CO17: Send pointers to large files maintained in the sending organization | Sending user is able to include in a message a URL/pointer to an image file (e.g.,
                        a scanned document or diagnostic image) maintained by the sending organization which
                        allows a message recipient to navigate to the stored image and view and download it | Diagnostic images and other large documents may not need to be sent as message attachments
                        in every case. Sending a pointer to the image/document allows the recipient the option
                        of viewing or downloading the document | 3 | 
               
               
                  
                  | CO18: Prevent the forwarding of information specifically protected by HIPAA, 42 CFR Part
                        2, or other applicable statute | Sending user is able to:  1. Specify special privacy protections for the message including the specific statute
                        or other restriction applicable to the data/message  2. Specify that a specific message SHALL not be forwarded  3. Assert that consent has been received compliant with the requirements of 42 CFR
                        Part 2 or other restriction authorizing the sending of the message The system can be configured at the organizational or user level to: 1. Display received information on special privacy protection to any recipient user.
                        An attempt to forward a message with specified special privacy protection results
                        in a warning to the user, who is alerted to the restriction and required to acknowledge
                        the warning prior to sending. The fact that the alert was presented and acknowledged
                        is logged by the system 2. Display received information on special privacy protection to any recipient user,
                        however, not permit forwarding of received messages specified as not to be forwarded | This recommendation prevents the distribution of patient information that would be
                        in violation of existing law or otherwise inappropriate | 3 | 
               
               
                  
                  | CO19: Message forwarding outside of recipient organization | Recipient user can forward a received message and/or any associated attachments to
                        one or more recipients at a different organization or using a different HIT system.
                        Forwarding of specially protected information is prevented or limited (see CO18) | Forwarding of messages supports team-based care by sharing information when care team
                        members are in different organizations | 3 | 
               
               
                  
                  | Inbound message functions | 
               
               
                  
                  | CI1: Automated patient identification | All EHRs, Health Information Service Providers (HISPs), and other HIT applications
                        receiving Direct messages automatically match incoming messages to the correct patient
                        for those already known within the recipient system. Only in the event that the patient
                        is new or cannot be automatically matched (e.g., a new referral to a specialist, or
                        patient demographics that might match more than one existing patient record), the
                        receiving system places the message in a work queue for manual matching or patient
                        registration | Patient matching must be automated to prevent impeding data flow to intended recipient(s)
                        and potentially creating an unsafe situation for the affected patient. With broad
                        adoption of Direct, timely care transitions and coordination require automatic matching.
                        Manual patient matching places an unsupportable burden on staff | 1 | 
               
               
                  
                  | CI2: Message attachments | The receiving systems must allow the recipient to open and view a wide variety of
                        content types received as message attachments including structured data (C-CDA, or
                        a template with a combination of C-CDA sections, document types, Excel spreadsheets,
                        etc.); unstructured data (Word, PDF, plain text files, etc.) and images (JPG, GIF
                        files, DICOM, etc.). Patient-context information contained in the message attachment
                        should be visible or accessible to the clinical user | Receiving systems must not strip attachments from the message and must be able to
                        consume all supported attachment types. Included attachments were deemed necessary
                        for the optimal care of the patient by the sender and thus must be consumable. This
                        recommendation will increase the confidence that a sent attachment will be viewable
                        by the intended recipient | 1 | 
               
               
                  
                  | CI3: Reliable recipient view | All clinically relevant message components and attachments (e.g., sender, intended
                        recipient, CCed recipients, message subject, message body text, message context, and
                        attachments) display reliably in a consistent manner to the receiving end user in
                        a personal in box. The content of standard documents (e.g., a document that conforms
                        to the C-CDA standard, or a template with a combination of C-CDA sections and/or document
                        types) are displayed to the user in a consistent format so that the user can become
                        familiar with the location of information in the document | The inbox as an access point for all data relating to the patient creates efficiency
                        and improves the chance that all the information will be reviewed. Consistent display
                        will familiarize the user with the format and allows for review that is more efficient | 1 | 
               
               
                  
                  | CI4: Standardized use of discrete data | Standardized data vocabularies are included in a uniform fashion to support transmission
                        of discrete data. Minimum requirements are problems, allergies, medications, immunizations
                        (PAMI), and procedures | Standardized vocabulary creates care and documentation efficiencies and data integration
                        capabilities prevent transmission, interpretation, and data entry errors | 1 | 
               
               
                  
                  | CI5: Recipient is able to view the sender's indicated message Priority | The recipient can view the message Priority indicated by the sender and can prioritize
                        his/her workflow based on this information | As clinicians frequently experience work force shortages and information overload,
                        this feature allows the recipient to prioritize his/her incoming messages | 2 | 
               
               
                  
                  | CI6: Message sorting functions | The recipient user, or his/her delegate, is able to sort the list of received messages
                        by common characteristics, including date/time of receipt, patient, sending user,
                        recipient user, context, priority, or subject | This standard email functionality allows recipients to manage messages efficiently | 2 | 
               
               
                  
                  | CI7 Incoming message notification | Receiving systems provides the ability to configure, either at the organization or
                        individual level, real-time notifications to recipients regarding the receipt of a
                        Direct message (e.g., to a specified email or text messaging account). These notifications
                        do not include PHI | This functionality protects users from the need to constantly check their application
                        for new messages | 2 | 
               
               
                  
                  | CI8 Message routing based on Context | Receiving systems support configurable routing of messages based on Context metadata
                        (e.g., discharge, referral, care coordination, etc.) received with the message. This
                        routing includes the following functionalities:  1. The ability for a recipient to designate another individual or a work queue to
                        process some or all of their messages on his/her behalf  2. The ability to write message handling rules to enable auto processing (e.g., CC
                        or forward) of messages based on sender, context, patient, or subject to another individual
                        or to a work queue for processing | Auto-routing of messages based on message Context increases efficiency of care coordination,
                        supports team-based care, and decreases clutter in the provider's inbox, and increases
                        usability and adoption of Direct messaging | 2 | 
               
               
                  
                  | CI9: Message forwarding to internal recipients without a Direct address | The recipient of a Direct message is able to forward the message and any attachments
                        to another user in of the same system in the same organization regardless of whether
                        the intended recipient is provisioned with a Direct address | Clinicians receiving clinical Direct messages may need to forward these messages to
                        others in their organization for processing even though these users may not be enabled
                        with the ability to send or receive external messages directly | 2 | 
               
         
         
         
         Abbreviations: ADT fields, Admission, Discharge, Transfer fields; C-CDA, Consolidated
            Clinical Document Architecture; HIPAA, Health Information Portability and Accountability
            Act; HIT, health information technology; PHI, protected health information.
         
          
      
      
      
      
         
            Table 3 
               Recommendations for administrative functions
               
            
               
               
                  
                  | 
                        Priority 1
                         | Required/Urgent/Now/Current-next version | 
               
               
                  
                  | 
                        Priority 2
                         | Highly desired/Future priority/1–2 y/Subsequent version | 
               
               
                  
                  | 
                        Priority 3
                         | Advanced/Future development | 
               
               
                  
                  | 
                        Administration
                         | 
               
               
                  
                  | 
                        Feature/Function
                         | 
                        Recommendation
                         | 
                        Rationale
                         | 
                        Priority
                         | 
               
               
                  
                  | Administrative functions | 
               
               
                  
                  | A1: Any clinical User may have a Direct account | All clinical Users have full individual Direct messaging capability regardless of
                        whether they have a National Provider Identifier (NPI), e.g., care managers, nurses,
                        etc. may have their own Direct account | A provider directory service may require including the NPI when publishing the user's
                        Direct address. While intended to provide clarity between similarly named providers,
                        many health care providers do not have NPIs and would therefore be excluded from the
                        directory. Utilization of secure clinical messaging for care managers, care coordinators,
                        social workers, therapists, etc. is foundational for team-based care of patients | 1 | 
               
               
                  
                  | A2: Locations and departments may have Direct accounts | Organizations have the capability to create departmental and location-based Direct
                        accounts to send and receive messages (e.g., messages intended for health information
                        management, admitting, the emergency department (ED), or other specific clinical departments)
                        in addition to accounts for ndividual clinicians | Utilization of secure messaging promotes patient care by involving clinicians and
                        other health care workers individually and based on departmental functions. For example,
                        a referral message could be routed to the referral staff, or a message regarding skilled
                        nursing placement to a case manager | 1 | 
               
               
                  
                  | A3: Manual entry of Direct addresses | Users have the ability to enter the Direct address of an intended recipient manually
                        in addition to selecting a recipient from a directory. This functionality should be
                        provided only in conjunction with the requirement for a Failed Message Delivery/Receipt
                        Notification given the risk of errors with manual data entry | There are situations where users may need to send a Direct message to a recipient,
                        whose address is not available in their HIT system's directory. As patients and additional
                        members of their care team are provisioned with Direct addresses, this recommendation
                        becomes increasingly important. Processes must exist to assure that nonfunctional
                        or erroneous addresses are validated or otherwise trigger an alert to the sending
                        user or surrogate so that alternate means of communication can be utilized | 2 | 
               
               
                  
                  | A4: Request patient-specific documents | A standard automated methodology exists to allow a Direct user to request a standard
                        C-CDA document and/or a template with a combination of C-CDA document types or sections
                        from another Direct user. The system allows the sender/requestor to specify the specific
                        document(s) requested (e.g., a patient summary/Continuity of Care Document [CCD],
                        discharge summary, or encounter summary), the modality to send the response (e.g.,
                        Direct message vs. fax), and where the document(s) should be sent (e.g., to a Direct
                        address or fax number) | While Direct is utilized primarily to push messages, it can also be used to mimic
                        some of the functionality of query-based, or “pull,” document exchange. Users can
                        send a message that requests a recipient system to automatically send patient information
                        to the requestor. For a patient in the ED, for example, the local HIT system could
                        manually or automatically query the EHR of the patient's primary care physician or
                        other treating provider for information and receive an automated response with a patient
                        summary CCD to facilitate safer, timelier, more efficient, and cost-effective care | 2 | 
               
               
                  
                  | A5: Customizable request for information | User can send a Direct message to request specific information from the recipient
                        using a configurable multiselect pick list to indicate the information requested | This recommendation facilitates receiving the specific information needed to most
                        efficiently and effectively care for the patient. It can avoid the inclusion of unnecessary
                        information, limiting the time and effort required to locate pertinent data | 3 | 
               
               
                  
                  | A6: Automatic forwarding when the addressee is unable to receive messages | When a user sends a message and the recipient is unable to receive the message, it
                        will be auto-forwarded to a designated user and/or pool | A sender may not know if the intended recipient of a message is out of the office,
                        covered by another provider, having outside messages routinely routed to another user
                        or pool, or has left the organization. Automated forwarding of the message to an assigned
                        back-up recipient/provider, who will assume care of the patient, or to a pool that
                        manages undeliverable messages will ensure that important patient-related messages
                        are not lost | 3 | 
               
               
                  
                  | A7: Nonpatient-specific administrative messages and attachments | Sending user can add one or more attachments to an outgoing non-patient-specific message.
                        Attachments will consistently be delivered with the message. Supported document types include documents that contain reports and information that
                        may apply to multiple patients or no patients and include, but are not limited to,
                        spreadsheets, PDF, and Word documents | The ability to utilize Direct messaging to support the secure transmission of non-patient-specific
                        messages and attachments supports communication which is required as a part of health
                        care organizations' administrative functions including quality improvement, insurance
                        preauthorization, and other billing and reporting functions | 3 | 
               
         
         
         
         Abbreviations: EHR, electronic health records; HIT, health information technology.
         
          
      
      
      
      
         
            Table 4 
               Categorization of recommended features/functions
               
            
               
               
                  
                  | Feature/Function | Priority 1 | Priority 2 | Priority 3 | Total | 
               
            
               
               
                  
                  | Transitions of care | Outbound message functions | 5 | 4 | 2 | 11 | 
               
               
                  
                  | Inbound message functions | 6 | 2 | 3 | 11 | 
               
               
                  
                  | Clinical messaging | Outbound message functions | 6 | 8 | 5 | 19 | 
               
               
                  
                  | Inbound message functions | 4 | 5 | 0 | 9 | 
               
               
                  
                  | Administrative functions |  | 2 | 2 | 3 | 7 | 
               
               
                  
                  | Total |  | 23 | 21 | 13 | 57 | 
               
         
       
      
      
      The largest number (23) of recommended features and functions is prioritized as priority
         1, or highest need, reflecting clinicians' urgent desire for basic messaging functionality
         to safely and efficiently utilize Direct messaging to support clinical care. These
         functionalities should be the primary focus of HIT vendors for current development
         to assure that all applications satisfy these basic requirements. The 21 features
         categorized as priority 2 are highly desired by clinicians and should be included
         in near term development for delivery and implementation ideally in the next 1 to
         2 years. The 13 functions designated as priority 3 include those that clinicians,
         HIT vendors, and other stakeholders believe will require more development, collaboration,
         and consensus building among clinicians, vendors, and other groups, and/or the further
         development of technology standards ([Table 4]).
      
      Some recommended functions apply to multiple use cases, e.g., transitions of care
         and clinical messaging, but are listed only once in the tables to avoid redundancy.
         Similar functions are listed more than once when associated with use case-specific
         recommendations or rationale. It is the intention of the authors that these recommendations
         be addressed by HIT vendors and policy makers as a whole, based on the priorities
         specified, rather than independently addressing the requirements for specific functions.
      
         
      
      Discussion
      
      These recommendations focus on communication between clinicians. Direct interoperability
         is and will be used across a wide variety of situations, systems, and groups. While
         other uses (e.g., Direct messaging between clinicians and patients) will also benefit
         from the implementation of the recommended features and functions, vendors and users
         should realize that additional requirements will likely be necessary in the future
         to address the unique needs of additional use cases.
      
      Some EHR and HIT vendors have already developed many of the recommended features and
         functions. Some of the advanced functions recommended will require not only the development
         of a new software by vendors, but also the evolution of the Direct Standard itself.
         An example of this is the development of an Implementation Guide for Expressing Context
         in Direct Messaging.[13]
         
      
      While the focus of this consensus statement is Direct interoperability, many recommendations
         also apply to other methods of secure clinical information exchange including query-based
         document exchange and interoperability using application-programming interfaces (APIs).
         The recommendations address issues of both message content/payload and transport,
         providing input and perspective from the viewpoint of clinicians who desire to utilize
         these interoperability methodologies to support the care of individuals and populations.
      
         
      
      Conclusion
      
      We recommend that the vendor community utilize this list of desired features and functions
         to ensure that the highest priority items are available to end users of Direct interoperability
         in the shortest possible timeframe, followed by the next highest priority group of
         features and functions. We further encourage policy makers to consider this list of
         clinically desirable functionality when establishing policies and regulations to support
         the interoperability of health information.
      
         
      
      Clinical Relevance Statement
      
      Automated, real-time sending and receipt of secure clinical messages and attachments
         via Direct interoperability by members of a patient's care team helps make them aware
         of care transitions and provides them with current clinical information. This enhances
         their ability to safely, efficiently, and effectively care for patients. Electronic
         sharing of clinical information across disparate organizations, EHRs, and other HIT
         systems can help to overcome barriers created by the patient's care teams' separate
         EHR systems and enables the creation and management of a shared patient care plan.
         Timely receipt of messages enhances the safety and efficiency of patient care by facilitating
         information reconciliation in the recipient systems and appropriate patient outreach
         to ensure patient understanding of the updated plan of care. It also helps prevent
         unnecessary duplicate testing and adverse events.
      
         
      
      Multiple Choice Questions
      
      
         
         - 
            
            EHR interoperability utilizing the Direct Protocol is currently: 
               
               - 
                  
                  Available in all Meaningful Use certified EHR systems 
- 
                  
                  Being tested in some EHR systems 
- 
                  
                  Is untested and is in development within the public/private sector 
 
               Correct Answer: The correct answer is option a. Direct interoperable capability has been required
               to be available in all Certified Electronic Health Record Technology (CEHRT) systems
               since the 2014 edition of certification. 
- 
            
            The use of structured vocabularies for problems, allergies, medications, immunizations,
               and procedures allows for: 
               
               - 
                  
                  Enhanced patient understanding of these elements 
- 
                  
                  EHR documentation of these elements as discrete data 
- 
                  
                  The ability for a Direct message recipient HIT system to consume these data elements
                     discretely 
- 
                  
                  b and c 
 
               Correct Answer: The correct answer is option d. The use of structured vocabularies for problems,
               allergies, medications, immunizations (called PAMI Data), and procedures allows HIT
               system end users to enter patient data as “discrete” or computable data. When these
               data are structured using a standard vocabulary, it allows an EHR or other HIT system
               receiving a Direct message containing discrete data to consume the data, thereby avoiding
               transcription errors and facilitating the use of received information for analytics,
               decision support, reporting, and other purposes. The use of structured vocabularies
               is unrelated to patient understanding of their clinical information. 
- 
            
            Optimal use of Direct interoperability requires 
               Correct Answer: The correct answer is option d. Like any other software implementation, optimal use
               of Direct interoperability requires configuration, consideration of role-based workflows
               within the organization, and end user training and support. The best implementation
               of Direct interoperability might also include considerations of role-based workflows
               across organizations where messages will be sent and received. 
         
      
         
      Conflict of Interest
      
      None.
      
      
      Acknowledgments
      
      The authors are grateful for the workgroup support of Kelly Gwynn, Natasha Kreisle,
         and DirectTrust; for the contributions of the workgroup members that are not listed
         as authors: David Camitta, MD, MS – Dignity Health, Margaret Donahue, MD – Veterans
         Affairs, Lucy Johns, MPH – DirectTrust, Francisco Rhein, MD – Dignity Health, and
         Steven Waldren, MD, MS – American Academy of Family Physicians; for the extensive
         comments and feedback provided by our clinical and information technology colleagues
         in response to the draft recommendations; and the Office of the National Coordinator
         for Health Information Technology, which provided a forum for the public presentation
         and discussion of the recommendations.
      
      Protection of Human and Animal Subjects 
      
      This manuscript does not involve any research on human subjects.
      
      
      
         - 
            References
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            Project. The Direct Project maintains a wiki at  http://wiki.directproject.org/ . A comprehensive overview of the Direct Project is The Direct Project Overview from
            February, 2010, available at:  http://wiki.directproject.org/file/view/DirectProjectOverview.pdf . Accessed March 01, 2018  . The technical protocols and specifications for Direct
            are specified in the Applicability Statement for Secure Health Transport of the Direct
            Project, available at:  http://wiki.directproject.org/Applicability+Statement+for+Secure+Health+Transport . Accessed March 01, 2018  
            
         
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            and Coordination.  White Paper: Feature and Function Recommendations to the HIT Industry
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      Address for correspondence
      Steven R. Lane, MD, MPH 
      Sutter Health, Palo Alto Medical Foundation
      795 El Camino Real, Palo Alto, CA 94301
      United States