Yearb Med Inform 2009; 18(01): 134-142
DOI: 10.1055/s-0038-1638652
Original Article
Georg Thieme Verlag KG Stuttgart

Biomedical Informatics and the Convergence of Nano-Bio-Info-Cogno (NBIC) Technologies

F. Martin-Sanchez
1   Medical Bioinformatics Dept., Institute of Health Carlos III, Ministry of Science and Innovation, Madrid, Spain
,
V. Maojo
2   Biomedical Informatics Group, Departamento de Inteligencia Artificial, Facultad de Informatica, Universidad Politecnica de Madrid, Madrid, Spain
› Author Affiliations
Further Information

Correspondence to

Fernando Martin-Sanchez
Medical Bioinformatics Dept. Institute of Health Carlos III
Ministry of Science and Innovation Majadahonda 28220
Madrid, Spain
Fax: +34 918223219   

Publication History

Publication Date:
07 March 2018 (online)

 

Summary

Objectives To analyze the role that biomedical informatics could play in the application of the NBIC Converging Technologies in the medical field and raise awareness of these new areas throughout the Biomedical Informatics community.

Methods Review of the literature and analysis of the reference documents in this domain from the biomedical informatics perspective. Detailing existing developments showing that partial convergence of technologies have already yielded relevant results in biomedicine (such as bioinformatics or biochips). Input from current projects in which the authors are involved is also used.

Results Information processing is a key issue in enabling the convergence of NBIC technologies. Researchers in biomedical informatics are in a privileged position to participate and actively develop this new scientific direction. The experience of biomedical informaticians in five decades of research in the medical area and their involvement in the completion of the Human and other genome projects will help them participate in a similar role for the development of applications of converging technologies —particularly in nanomedicine.

Conclusions The proposed convergence will bring bridges between traditional disciplines. Particular attention should be placed on the ethical, legal, and social issues raised by the NBIC convergence. These technologies provide new directions for research and education in Biomedical Informatics placing a greater emphasis in multidisciplinary approaches.


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  • References

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  • 3 Anton PS, Silberglitt R, Schneider J. The global technology revolution. Bio/Nano/Materials trends and their synergies with information technology by 2015. Santa Monica, CA: RAND National Defense Research Institute (NDRI); 2001
  • 4 Roco MC, Bainbridge WS. editors. Converging technologies for improving human performance. Nanotechnology, biotechnology, information technology and cognitive science. Arlington, Virginia: National Science Foundation (NSF) / Department of Commerce (DOC); 2002
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  • 7 EC Project Knowledge Politics and New Converging Technologies; A Social Science Perspective. Available from: http://www.converging-technologies.org/index.html June 2009..
  • 8 European Parliament. Directorate-General for Internal Policies of the Union. ETAG European Technology Assessment Group. Technology Assessment on Converging Technologies. IP/A/STOA/SC/2005-183. October; 2006
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  • 10 Converging Technologies Forum 2007. Barcelona, Spain: Available from: http://nbic.org.es/forum2007/ June 2009..
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  • 20 Kuhn KA, Knoll A, Mewes HW, Schwaiger M, Bode A, Broy M. et al. Informatics and medicine-from molecules to populations. Methods Inf Med 2008; 47 (04) 283-95.
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  • 22 Liu KH, Xu CG. A genetic programming-based approach to the classif ication of multiclass microarray datasets. Bioinformatics 2009; 25 (03) 331-7.
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  • 24 Covitz P. caBIG™ and Nanotechnology Informatics. Available from: http://128.119.56.118/∼nnn01/NewFiles/04_Covitz_caBIG.pdf June 2009
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  • 29 Altman RB, Balling R, Brinkley JF, Coiera E, Consorti F, Dhansay MA. et al. Commentaries on “Informatics and medicine: from molecules to populations”. Methods Inf Med 2008; 47 (04) 296-317.
  • 30 Martin-Sanchez F, Lopez-Alonso V, Hermosilla-Gimeno I, Lopez-Campos GA. Primer in Knowledge Management for Nanoinformatics in Medicine. In Proceedings of the KES Conference 2008. Zagreb, Croatia.:
  • 31 Chiesa S, García-Remesal M, de la Calle G, de la Iglesia D, Bankauskaite V, Maojo V. Building an Index of Nanomedical Resources: an Automatic Approach based on Text Mining. In proceedings of the KES 2008. Zagreb, Croatia.:
  • 32 Grillner S. et al. Integrative Neuroscience: Linking levels of analyses. Current Opinion in Biotechnology 2005; 15: 614-21.
  • 33 Report on Neuroinformatics from The Global Science Forum Neuroinformatics Working Group of the Organisation for Economic Co-operation and Development June. 2002
  • 34 http://bluebrain.epfl.ch/ June 2009.
  • 35 Horn RE. Visual Language and Converging Technologies in the Next 10-15 Years (and Beyond) A paper prepared for the National Science Foundation Conference on ConvergingTechnologies (Nano-BioInfo-Cogno) for Improving Human Performance. Dec. 3-4, 2001
  • 36 Cachau RE, Gonzalez-Nilo FD, Ventura ON, Fritts MJ. In-silico nano-biodesign. A new frontier in computational biology. Current Topics in Medicinal Chemistry 2007; 07 (15) 1537-40.
  • 37 Roco MC. Nanotechnology: convergence with modern biology and medicine. Current Opinion in Biotechnology 2002; 14 (03) 337-46.
  • 38 Chen JM, Ho CM. Path to bio-nano-information fusion. Ann N Y Acad Sci 2006; 1093: 123-42.
  • 39 Lymberis A. Converging Micro-Nano-Bio-Information & Communication Technologies Towards Integrated Systems: the Contribution of the EU Information SocietyTechnologies Program. Engineering in Medicine and Biology Society. EMBS 2007. 29th Annual International Conference of the IEEE 22-26 Aug 2007. 6445.
  • 40 Goodsell D. Bionanotechnology: Lessons from Nature. Wiley; 2004
  • 41 Kulkarni RP. Nano-Bio-Genesis: Tracing the rise of nanotechnology and nanobiotechnology as ‘big science’. J Biomed Discov Collab 2007; 02: 3.
  • 42 Jain KK. The role of nanobiotechnology in drug discovery. Drug Discov Today 2005; 10 (21) 1435-42.
  • 43 Weissleder R. Molecular imaging in cancer. Science 2006; 312 5777 1168-71.
  • 44 Politz J, Pombo A. Genomics meets nanoscience: probing genes and the cell nucleus at 10-9 meters. Genome Biology 2002; 03 (03) 4007.1-4007.3
  • 45 Caffrey P. (Chair) et al. Taskforce convened by Engineers Ireland and the Irish Academy of Engineering. A Picture of Health in 2030. Engineering the Future of Health and Medicine; 2006. Available from: http://www.emgineersireland.ie
  • 46 Freitas RA. What is nanomedicine?. Nanomed Nanotechnol. Biol Med 2005; 01: 2e9.
  • 47 Kewal KJ. The Handbook of Nanomedicine. Totowa, NJ: Humana Press; 2008
  • 48 Kubik T, Bogunia-Kubik K, Sugisaka M. Nanotechnology on duty in medical applications. Curr Pharm Biotechnol 2005; 06: 17-33.
  • 49 European Technology Platform on NanoMedicine. Nanotechnology for Health: Vision Paper and Basis for a Strategic Research Agenda for NanoMedicine. 2005 Available from: http://cordis. europa.eu/nanotechnology/nanomedicine.htm.
  • 50 European Science Fundation - European Medical Research Councils (EMRC). Forward look on Nanomedicine. 2005
  • 51 Pritchard J, Binks P, Critchley M, Irving B. Nanotechnology: the next wave of commercial development for health and medical devices-an Australian story. Nanomed 2007; 02 (02) 255-60.
  • 52 Williams D. Medical nanotechnology: how small can we go?. Med Device Technol 2002; Apr; 13 (03) 7-9.
  • 53 Hatton P, Wallace WA, Lloyd-Evans M, Silcock D, Lewis A, Jackson A. DTI Global Watch Mission Report – The impact of converging technologies on medical devices – a mission to the USA – October 2005. Published by Pera on behalf of the DTI. Crown. 2006
  • 54 Martin-Sanchez F, Maojo V, Pazos A, Dorado J, Guerrero A. Converging Technologies for the Improvement of Clinical Diagnosis and Management at the Point of Care (POC). Proceedings of the Workshop held at Converging Technologies Forum, 2007. Barcelona: CSIC-UAM. 2007
  • 55 Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam MR. et al. Microfluidic diagnostic technologies for global public health. Nature 2006; 442 7101 412-8.
  • 56 Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D. Light-Directed, Spatially Addressable Parallel Chemical Synthesis. Science 1991; 251: 767-73.
  • 57 Giorgi L, Luce J. editors. Converging Science and Technologies: Research Trajectories and Institutional Settings, Special Issue of Innovation; The European. Journal of Social Science Research. 2007 20. 04
  • 58 Luce J, Giorgi L. editors. Knowledge Politics and Converging Technologies, Special Issue of Innovation; the European Journal of Social Science Research. 2009 22. 01
  • 59 Fuller S. Knowledge NBIC. Knowledge Politics and new Converging Technologies: A Social Science Perspective. http://www.converging-technologies.org.
  • 60 Schicktanz S. Why the way we consider the body matters – Reflections on four bioethical perspectives on the human body. Philos Ethics Humanit Med 2007;2:30. Published online 2007 December 4. doi: 10.1186/1747-5341-2-30..
  • 61 Roco MC. Converging science and technology at the nanoscale: opportunities for education and training. Nat Biotechnol 2003; Oct; 21 (10) 1247-9.
  • 62 Gorman ME. Collaborating on convergent technologies: education and practice. Ann N Y Acad Sci 2004; 1013: 25-37.
  • 63 The Joint Commission. Sentinel Event Alert. Safely implementing health information and converging technologies. 2008 42 December 11..

Correspondence to

Fernando Martin-Sanchez
Medical Bioinformatics Dept. Institute of Health Carlos III
Ministry of Science and Innovation Majadahonda 28220
Madrid, Spain
Fax: +34 918223219   

  • References

  • 1 Toffler A. The Third Wave. New York: Bantam; 1980
  • 2 Gingrich N. The age of transitions. In Roco M, Bainbridge WS. editors. Social implications of nanoscience and technology. NSET workshop report. Dordrecht, Boston, London: Kluwer; 2001
  • 3 Anton PS, Silberglitt R, Schneider J. The global technology revolution. Bio/Nano/Materials trends and their synergies with information technology by 2015. Santa Monica, CA: RAND National Defense Research Institute (NDRI); 2001
  • 4 Roco MC, Bainbridge WS. editors. Converging technologies for improving human performance. Nanotechnology, biotechnology, information technology and cognitive science. Arlington, Virginia: National Science Foundation (NSF) / Department of Commerce (DOC); 2002
  • 5 Bouchard R. Bio–Systemics Synthesis: Science and Technology Foresight Pilot Project. Technical report, Canadian Research Council; Ottawa: 2003
  • 6 Nordmann A. (Rapp) and the High Level Expert Group - Foresighting the New Technology Wave. Report “Converging Technologies – Shaping the Future of European Societies”. 2004
  • 7 EC Project Knowledge Politics and New Converging Technologies; A Social Science Perspective. Available from: http://www.converging-technologies.org/index.html June 2009..
  • 8 European Parliament. Directorate-General for Internal Policies of the Union. ETAG European Technology Assessment Group. Technology Assessment on Converging Technologies. IP/A/STOA/SC/2005-183. October; 2006
  • 9 Aguiló J. Tecnologías Convergentes NBIC, Situación y Perspectiva. (2005), CBN-IBM, IIBB, IIIA, CSIC Barcelona. Available from http://nbic.org.es/institute/downloads-eu/NBIC-2005.pdf. June 2009
  • 10 Converging Technologies Forum 2007. Barcelona, Spain: Available from: http://nbic.org.es/forum2007/ June 2009..
  • 11 Martin-Sanchez F, Lopez-Campos G. Convergencia deTecnologías: nuevas oportunidades para el avance de la Informática y de las Ciencias Biomédicas. Revista e-salud (2006). Available from: http://www.RevistaeSalud.com, Vol 2, No 6. June 2009
  • 12 Kodama, Fumio. Technology fusion and the new R&D. Harvard Business Review 1992; July-August:70-8..
  • 13 Schummer J. Interdisciplinary Issues in Nanoscale Research. In: Baird D, Nordmann A, Schummer J. editors. Discovering the Nanoscale. Amsterdam: IOS Press; 2004
  • 14 Andler D, Barthelmé S, Beckert B, Blümel C, Coenen C, Fleischer T. et al. Converging Technologies and their impact on the Social Sciences and Humanities. Final report of the CONTECS project. May (2008). Available from: http://www.contecs.fraunhofer.de June 2009.
  • 15 Roska T, Werblin FS, Pin JE. editors. European Commission -US National Science Foundation - Strategic Research Workshop “BIONICS - Bio-inspired Information Technologies”. Report and Recommendations. Brussels. 2001
  • 16 http://14dec2001.ramit.be/ June, 2009..
  • 17 Martin-Sanchez F, Iakovidis I, Norager S, Maojo V, de Groen P, Van der Lei J. et al. Synergy between medical informatics and bioinformatics: facilitating genomic medicine for future health care. J Biomed Inform 2004; 37 (01) 30-42.
  • 18 Meeting Report. “Extending the scope of ICT at the crossroads with life sciences”. An European Commission IST Workshop contributing to future research priorities October; Brussels: 2004
  • 19 Martin-Sanchez F. editor. Bio-inspired computing. Final report of the European Project Beyond-The-Horizon. Thematic Group 4. Available from: ftp://ftp.cordis.europa.eu/pub/ist/docs/fet/strat-4.pdf June 2009..
  • 20 Kuhn KA, Knoll A, Mewes HW, Schwaiger M, Bode A, Broy M. et al. Informatics and medicine-from molecules to populations. Methods Inf Med 2008; 47 (04) 283-95.
  • 21 Spicker JS, Wikman F, Lu ML, Cordon-Cardo C, Workman C, ØRntoft TF. et al. Neural network predicts sequence of TP53 gene based on DNA chip. Bioinformatics 2002; 18 (08) 1133-4.
  • 22 Liu KH, Xu CG. A genetic programming-based approach to the classif ication of multiclass microarray datasets. Bioinformatics 2009; 25 (03) 331-7.
  • 23 Workshop on Nanoinformatics Strategies. Available from: http://128.119.56.118/∼nnn01/Workshop.html June 2009..
  • 24 Covitz P. caBIG™ and Nanotechnology Informatics. Available from: http://128.119.56.118/∼nnn01/NewFiles/04_Covitz_caBIG.pdf June 2009
  • 25 Baker NA, Guccione S, Paik D, Pappu RV, Patri A, Rubin D. et al. Nanotechnology Informatics White Paper, caBIG Integrative Cancer Research Nanotechnology Working Group, February. 2009
  • 26 ACTION-Grid project website. http://www.action-grid.eu June 2009.
  • 27 Lopez-Alonso V, Hermosilla-Gimeno I, Lopez-Campos G, Maojo V, Martin-Sanchez F. Action GRID: assessing the impact of Nanotechnology on Biomedical Informatics. AMIA Annu Symp Proc. 2008 Nov 6: 1046.
  • 28 Maojo V, Kulikowski CA. Reflections on Biomedical Informatics: From Cybernetics to Genomic Medicine and Nanomedicine. Stud Health Technol Inform 2006; 124: 19-24.
  • 29 Altman RB, Balling R, Brinkley JF, Coiera E, Consorti F, Dhansay MA. et al. Commentaries on “Informatics and medicine: from molecules to populations”. Methods Inf Med 2008; 47 (04) 296-317.
  • 30 Martin-Sanchez F, Lopez-Alonso V, Hermosilla-Gimeno I, Lopez-Campos GA. Primer in Knowledge Management for Nanoinformatics in Medicine. In Proceedings of the KES Conference 2008. Zagreb, Croatia.:
  • 31 Chiesa S, García-Remesal M, de la Calle G, de la Iglesia D, Bankauskaite V, Maojo V. Building an Index of Nanomedical Resources: an Automatic Approach based on Text Mining. In proceedings of the KES 2008. Zagreb, Croatia.:
  • 32 Grillner S. et al. Integrative Neuroscience: Linking levels of analyses. Current Opinion in Biotechnology 2005; 15: 614-21.
  • 33 Report on Neuroinformatics from The Global Science Forum Neuroinformatics Working Group of the Organisation for Economic Co-operation and Development June. 2002
  • 34 http://bluebrain.epfl.ch/ June 2009.
  • 35 Horn RE. Visual Language and Converging Technologies in the Next 10-15 Years (and Beyond) A paper prepared for the National Science Foundation Conference on ConvergingTechnologies (Nano-BioInfo-Cogno) for Improving Human Performance. Dec. 3-4, 2001
  • 36 Cachau RE, Gonzalez-Nilo FD, Ventura ON, Fritts MJ. In-silico nano-biodesign. A new frontier in computational biology. Current Topics in Medicinal Chemistry 2007; 07 (15) 1537-40.
  • 37 Roco MC. Nanotechnology: convergence with modern biology and medicine. Current Opinion in Biotechnology 2002; 14 (03) 337-46.
  • 38 Chen JM, Ho CM. Path to bio-nano-information fusion. Ann N Y Acad Sci 2006; 1093: 123-42.
  • 39 Lymberis A. Converging Micro-Nano-Bio-Information & Communication Technologies Towards Integrated Systems: the Contribution of the EU Information SocietyTechnologies Program. Engineering in Medicine and Biology Society. EMBS 2007. 29th Annual International Conference of the IEEE 22-26 Aug 2007. 6445.
  • 40 Goodsell D. Bionanotechnology: Lessons from Nature. Wiley; 2004
  • 41 Kulkarni RP. Nano-Bio-Genesis: Tracing the rise of nanotechnology and nanobiotechnology as ‘big science’. J Biomed Discov Collab 2007; 02: 3.
  • 42 Jain KK. The role of nanobiotechnology in drug discovery. Drug Discov Today 2005; 10 (21) 1435-42.
  • 43 Weissleder R. Molecular imaging in cancer. Science 2006; 312 5777 1168-71.
  • 44 Politz J, Pombo A. Genomics meets nanoscience: probing genes and the cell nucleus at 10-9 meters. Genome Biology 2002; 03 (03) 4007.1-4007.3
  • 45 Caffrey P. (Chair) et al. Taskforce convened by Engineers Ireland and the Irish Academy of Engineering. A Picture of Health in 2030. Engineering the Future of Health and Medicine; 2006. Available from: http://www.emgineersireland.ie
  • 46 Freitas RA. What is nanomedicine?. Nanomed Nanotechnol. Biol Med 2005; 01: 2e9.
  • 47 Kewal KJ. The Handbook of Nanomedicine. Totowa, NJ: Humana Press; 2008
  • 48 Kubik T, Bogunia-Kubik K, Sugisaka M. Nanotechnology on duty in medical applications. Curr Pharm Biotechnol 2005; 06: 17-33.
  • 49 European Technology Platform on NanoMedicine. Nanotechnology for Health: Vision Paper and Basis for a Strategic Research Agenda for NanoMedicine. 2005 Available from: http://cordis. europa.eu/nanotechnology/nanomedicine.htm.
  • 50 European Science Fundation - European Medical Research Councils (EMRC). Forward look on Nanomedicine. 2005
  • 51 Pritchard J, Binks P, Critchley M, Irving B. Nanotechnology: the next wave of commercial development for health and medical devices-an Australian story. Nanomed 2007; 02 (02) 255-60.
  • 52 Williams D. Medical nanotechnology: how small can we go?. Med Device Technol 2002; Apr; 13 (03) 7-9.
  • 53 Hatton P, Wallace WA, Lloyd-Evans M, Silcock D, Lewis A, Jackson A. DTI Global Watch Mission Report – The impact of converging technologies on medical devices – a mission to the USA – October 2005. Published by Pera on behalf of the DTI. Crown. 2006
  • 54 Martin-Sanchez F, Maojo V, Pazos A, Dorado J, Guerrero A. Converging Technologies for the Improvement of Clinical Diagnosis and Management at the Point of Care (POC). Proceedings of the Workshop held at Converging Technologies Forum, 2007. Barcelona: CSIC-UAM. 2007
  • 55 Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam MR. et al. Microfluidic diagnostic technologies for global public health. Nature 2006; 442 7101 412-8.
  • 56 Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D. Light-Directed, Spatially Addressable Parallel Chemical Synthesis. Science 1991; 251: 767-73.
  • 57 Giorgi L, Luce J. editors. Converging Science and Technologies: Research Trajectories and Institutional Settings, Special Issue of Innovation; The European. Journal of Social Science Research. 2007 20. 04
  • 58 Luce J, Giorgi L. editors. Knowledge Politics and Converging Technologies, Special Issue of Innovation; the European Journal of Social Science Research. 2009 22. 01
  • 59 Fuller S. Knowledge NBIC. Knowledge Politics and new Converging Technologies: A Social Science Perspective. http://www.converging-technologies.org.
  • 60 Schicktanz S. Why the way we consider the body matters – Reflections on four bioethical perspectives on the human body. Philos Ethics Humanit Med 2007;2:30. Published online 2007 December 4. doi: 10.1186/1747-5341-2-30..
  • 61 Roco MC. Converging science and technology at the nanoscale: opportunities for education and training. Nat Biotechnol 2003; Oct; 21 (10) 1247-9.
  • 62 Gorman ME. Collaborating on convergent technologies: education and practice. Ann N Y Acad Sci 2004; 1013: 25-37.
  • 63 The Joint Commission. Sentinel Event Alert. Safely implementing health information and converging technologies. 2008 42 December 11..