Summary
Some biological properties of a synthetic peptide based on an anticoagulant peptide
obtained from fibrinogen degradation products by the action of plasmin are reported.
This peptide produced smooth muscle contraction without the presence of bradykinin.
The contraction caused by this peptide was not modified by atropin (10-6 g/ml), hyoscine (10-6 g/ml) and tetrodotoxin (2xl0-7 g/ml). A hypotensive effect was observed following the intravenous injection of the
peptide into an anesthetized rat indicating that this peptide has an action similar
to that of bradykinin though less potent.
