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Thromb Haemost 1973; 29(01): 050-062
DOI: 10.1055/s-0038-1647745
Original Article
Schattauer GmbH

The Plasminogen-Plasmin System Part VIII On the Mechanism of Chemical Induction of Fibrinolysis Isolation of a Latent Plasminogen Activator from Human Plasma

Munehiro Tomikawa
1   Research Laboratories, Daiichi Seiyaku Co., Ltd., Edogawa-ku, Tokyo, Japan
,
Yasushi Abiko
1   Research Laboratories, Daiichi Seiyaku Co., Ltd., Edogawa-ku, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

Received 06 March 1972

Publication Date:
30 June 2018 (online)

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Summary

A component, responsible for the chemical induction of fibrinolysis by flufenamate, was isolated from human plasma. The isolation procedures included removal of euglobulin precipitate from plasma, Sephadex G-200 gel filtration of the euglobulin- supernatant fraction and isoelectric focusing. The partially purified component was immunologically distinct from ßioglobulin, plasmin and plasminogen. Plasminogen activator activity was liberated from the component by treatment with flufenamate. The mechanism of induction of fibrinolysis by flufenamate is discussed.

 

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